DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and si:ch211-106j24.1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_021327531.1	Gene:	si:ch211-106j24.1 / 555478	ZFINID:	ZDB-GENE-130530-595	Length:	960	Species:	Danio rerio

Alignment Length:	971	Identity:	317/971 - (32%)
Similarity:	495/971 - (50%)	Gaps:	67/971 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GYWLQVVLSW-AVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTDYRL 68
            ||::...|:. |::..|.|.|.:........|:......|:......:.....:...|....|||
Zfish     4 GYYISKHLATAAMILAAIALVTIIALSVVYNREKSKNTAKLTNATTSAVPPTPKPSNEPWDKYRL 68

  Fly    69 PTNLVPTHYEL-YWHPDLETGN----FTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEK 128
            |..|.|.:|.: .|...:...|    |||...:....|:.|:.|::||..|::|   :.|....|
Zfish    69 PDTLSPQYYNITLWPQMVMDANGMYIFTGISDVMFTCVKKTDLILIHSNKLNLT---LFNGRHAK 130

  Fly   129 FE--------------LEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAG 179
            ..              |:.:.|:|:|.|..:|....|..|...|.|::.|.|.|.|.|.|: |.|
Zfish   131 LTGMSGVTAPAIKSTWLQTQTQYLVIQLKGKLNPGKSYWLHTEFTGELADDLEGFYRSEYM-EDG 194

  Fly   180 ATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQ--TESNYLGD--YTE 240
            ..:.|:.|:.:.||||:||||||||.|||.|.|.::|..| ..|:||.|:  ||...:.:  .|.
Zfish   195 EKKIIAITQMQATYARKAFPCFDEPGMKAVFNIILIHDRG-MTALSNSQEIRTEDVIIDEMPVTR 258

  Fly   241 AIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQIN--KVEFALEFGQAVTE 303
            ..||.:..||||||..:||||:..:...||..:     ::.:|....|:  :.::||...|.:.|
Zfish   259 TTFEPTARMSTYLVAFVVSDFSYINNEDKAGVL-----VRIWARKKAIDDGQGDYALSITQPILE 318

  Fly   304 YYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIA 368
            ::..||...|||:|.|..|:|||.|||||:|||||||||||||||..|:..|||.||..::||:|
Zfish   319 FFESYYNTSYPLSKSDQVALPDFNSGAMENWGLVTYRETALLYDPQTSANGNKQRIATVVSHELA 383

  Fly   369 HQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIV 433
            |.|||||||:|||||||||||||.|::|.|.:...|.|.:.:|..:..:|.....|:..||||:.
Zfish   384 HMWFGNLVTLKWWNDLWLNEGFASYVEYLGADHAEPTWNIKDQIILYDMQRAFAVDSLTSSHPLS 448

  Fly   434 QK---VESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDF---- 491
            :|   |.:|.||:.:|.||||.||.:|::||...:....|.:.::|||.:..|.::|..|.
Zfish   449 RKEEEVNTPAEISEMFSTISYSKGAAVLKMLSEFLTEPVFAKGLSNYLKQFAFGSSVHSDLWDHL 513

  Fly   492 ---LTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAY 553
               |.:...:.....|.::|..|..|||:||:.:. ...|:  |:|:.||....:..|..|:  :
Zfish   514 QKSLDQAPGMKLPRSIHEIMSRWILQMGFPVITID-TRTGN--VSQKHFLVEKDAVVERKSE--F 573

  Fly   554 GYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEV---QWIKLNVNQTGYYRVNYEESLWALL 615
            .|:|.|||.|......::..   :.:....|..|.:|   :|:..|...:||:||||:...|..|
Zfish   574 NYEWFVPIKWMKKGQVQDQM---WLLQKSAIHKPMKVSKGEWVLANHKVSGYFRVNYDHGNWERL 635

  Fly   616 IQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHR 680
            :.||.|:.....:.:|..:|:|||.||.|:.::..:.|..|.||.:||:::||..|...|....:
Zfish   636 LSQLETNHQTIPVVNRAQILDDAFNLARASIINITLALRTTKYLVREREYIPWEAALRSLNYFFQ 700

  Fly   681 SLMFSEGYVSYLTYARSLIAGVYEEVG-----WTVDADNHLKNRLRVSILTAACALGVPDCLQQA 740
            ....:|.|.:...|.:..:..::|..|     ||...:.|.....::..|:.||..||..|.:..
Zfish   701 LFDRNEVYGALQAYLKKQVKPLFEHFGTISSNWTKVPNGHTDQFTQIIALSLACGTGVEGCREIT 765

  Fly   741 SERFSTFLENPTTRP-SPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVR 804
            ...|..:::||...| .|:||..||...: .:.....|:..:|:|...|.|:|.:||...|:..:
Zfish   766 KSWFKKWMQNPRVNPIHPNLRSTVYCNAI-AAGGADEWNFGWQMFQKATVAAEAVKLRAALACTK 829

  Fly   805 NSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGR 869
            ....|..:|..:.:.|.| |.||..:.:.|||:|.:|:|:.|:|.|..|......:|..:..|.|
Zfish   830 VPWLLNRYLEYSINPEKI-RKQDATSTIGYIASNVIGQPLAWDFVRANWDYFFKVYGTGSFTFSR 893

  Fly   870 LIAQITANFASSVKLEEVQHFFSKYPESGAGANSRL--EAVETIKYNIEWLSRNEADITDW 928
            ||:.||:.|.:..:|.:::.|.....|:|.|:.::.  :|:|.....|:||:.|:..:..|
Zfish   894 LISDITSKFCTPFELSQLKRFQKDNAETGFGSGTQALQQAIERTTAKIKWLAENKEPVLQW 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	169/414 (41%)
		M1_APN_2	75..518	CDD:189008	183/477 (38%)
		ERAP1_C	593..910	CDD:288671	93/324 (29%)
si:ch211-106j24.1	XP_021327531.1	M1_APN_2	77..543	CDD:189008	183/475 (39%)
si:ch211-106j24.1	XP_021327531.1	PepN	170..943	CDD:223385	275/789 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.950