DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	988	Identity:	325/988 - (32%)
Similarity:	513/988 - (51%)	Gaps:	103/988 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GYWLQVVLSWAVVAFATA--------TVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKRE 61
            |:::...|::.::|.|..        :::.|.:|.:.|.::  |.:.:.....:|    |.:...
Zfish     4 GFYISKPLAFVLLALAVGSLLTILGLSLIYAQEKRRNEENM--VNNTVTTLAPYS----TSIPSN 62

  Fly    62 DTTD-YRLPTNLVPTHYELYWHP-----DLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVY 120
            :..| ||||..|:|.:|.:...|     ||....|||:..::...|:.|:.|::||..|:    |
Zfish    63 EPWDKYRLPDTLLPEYYNITLWPRLTKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLN----Y 123

  Fly   121 VLNREVEKFEL----------------EEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGL 169
            .|..|....||                :::.:|::|.|.|.|.|..|..|...|.|::.|.|.|.
Zfish   124 SLTAEKHHAELMGLGGTRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLGGF 188

  Fly   170 YSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNY 234
            |.|.|: |.|..:.::||:.:||.||.||||||||:|||.|.:|::||.|:....:.|:....|.
Zfish   189 YRSEYV-ENGVEKVVATTQMQPTAARTAFPCFDEPSMKAVFHLTLIHPPGTVALANGMETGTENI 252

  Fly   235 LGDYTEAI---FETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVE--FA 294
            ..:..:.:   ||.:..|||||:..::|:|.|..:.:.||.|    .::.:.....|...|  :|
Zfish   253 TIENQQVLQTRFEPTEKMSTYLLAFVISEFPSIQSPLGANKI----LVRIWGRREAIENGEGDYA 313

  Fly   295 LEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSI 359
            |.....|.:|...||...|||:|.|..|:|||::||||:|||||||||.|.|:|..||..:|:.:
Zfish   314 LNVTFPVLKYLESYYNTTYPLSKSDQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGV 378

  Fly   360 AGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYD 424
            ...::||:||.||||||||:||||||||||||.|:.|...:...|.|.:.|...:..:......|
Zfish   379 ITVISHELAHMWFGNLVTMRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVD 443

  Fly   425 AKLSSHPIVQK---VESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNT 486
            |.:||||:..:   |.:|.:|..:||.::|.||.:|:|||...:....|.:.:.|||.:|.::||
Zfish   444 ALVSSHPLSSREDAVNTPQQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNT 508

  Fly   487 VTDDFLTEVEAVVTDLD--------IKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPAS 543
            |..|...:::. |.|.|        |:::|..|..|.|:||:.:. ...||  ::||.||.:|.:
Zfish   509 VYTDLWKKLQE-VADSDGNVHLPASIEEIMNRWILQAGFPVVTID-THTGS--ISQQHFLIDPEA 569

  Fly   544 YEEAPSDSAYGYKWSVPITWFADDGS-------ENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTG 601
            ....|||  |.|:|.|||||..:..:       ..|..|:        .:.:|..||..|:|.||
Zfish   570 VVNKPSD--YNYEWFVPITWMKNGRNMGQHWLLNKSTSYE--------LMKTETNWILANLNVTG 624

  Fly   602 YYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFV 666
            ||||||:...|..||:|||:......:.:||.:::|||.||.|..|:..:.|..|.||:.|::::
Zfish   625 YYRVNYDSQNWERLIKQLTSDHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYI 689

  Fly   667 PWYVASNKLRSLHRSLMFSEGYV--SYLTYARSLIAGVYE-----EVGWTVDADNHLKNRLRVSI 724
            ||..|...|.  :..|||....|  ....|.|..:..::.     ...||.....|:....:::.
Zfish   690 PWESAIRNLE--YFFLMFDRTEVRGPLEAYLRRKVEPLFHYFKVITSNWTRKPTRHMDQYNQLNA 752

  Fly   725 LTAACALGVPDCLQQASERFSTFLENPTTRPSP-DLREIVYYYGMQQSTSQSSWDQLFQLFVAET 788
            :|.||...|..|.:..|..:..::::|...|.| ||:.:||...: .:.....||..:.:|...|
Zfish   753 ITMACKTRVKACSELTSMWYRQWMKDPNVNPVPSDLKTVVYCNAI-AAGGVEEWDFGWAMFKNST 816

  Fly   789 DASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQW 853
            .|:|..|||||||..:....|..:|..| .|.:::|.||....:.|||:|.:|:|:.|:|:|.:|
Zfish   817 VAAEAEKLMYGLSCTKEPWLLNRYLHYA-IDPNLIRKQDVTYPIVYIASNVIGQPLAWDFFRAKW 880

  Fly   854 PQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGA--GANSRLEAVETIKYNIE 916
            ..:||.|.:       ||..|...|::..:|:::|.|..:..|||.  |.::..:|:|..|.|::
Zfish   881 QLMTTEFRV-------LILGIVKTFSTEFQLQQLQRFQEEVAESGVSLGTHAIEQAIEQTKANVK 938

  Fly   917 WLSRNEADITDWL 929
            |:|.|:..:.|||
Zfish   939 WVSENKVQVMDWL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	155/415 (37%)
		M1_APN_2	75..518	CDD:189008	173/479 (36%)
		ERAP1_C	593..910	CDD:288671	102/326 (31%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	173/477 (36%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	104/330 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6076
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.820