DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and ERAP1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	936	Identity:	317/936 - (33%)
Similarity:	488/936 - (52%)	Gaps:	89/936 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 WSGESRTRMKREDTTDY-----RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIIL 109
            |...:....||.|.|.:     |||..::|.||:|..|.:|.|..|.|..::.|...:.|:.|||
Human    31 WCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIIL 95

  Fly   110 HSYLLDITSVYVLNREVEKFE------LEEERQFLIITLT-EELAVDASITLGIIFGGQMKDKLV 167
            ||:.|.|:...:.....|:..      ||..||..|..|. |.|.|....|:.|.:.|.:.:...
Human    96 HSHHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFH 160

  Fly   168 GLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTES 232
            |.|.|||..:.|..|.:::|:||||.||.|||||||||.||:|:|. :.....:.|:|||...:|
Human   161 GFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIK-IRREPRHLAISNMPLVKS 224

  Fly   233 NYLGD-YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALE 296
            ..:.: ..|..|:.:|.||||||..|:|||.|.|...| :|:    .:..||...:||:.::||:
Human   225 VTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITK-SGV----KVSVYAVPDKINQADYALD 284

  Fly   297 FGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAG 361
            ....:.|:|..|:.:||||.|.|:||||||.|||||:|||.||||:|||:|...||.::|..|..
Human   285 AAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITM 349

  Fly   362 TLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAK 426
            |:|||:|||||||||||:||||||||||||::|::..|:..||:..:.:.| .......:..||.
Human   350 TVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYF-FGKCFDAMEVDAL 413

  Fly   427 LSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDF 491
            .||||:...||:|.:|..:||.:||:||..::.||...:.|:.|:..:..||.||.:.||..:|.
Human   414 NSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDL 478

  Fly   492 LTEVEAVV-TD-------------------------LDIKKLMLTWTEQMGYPVLNVSKVADGSF 530
            ...:.::. ||                         :|:|.:|.|||.|.|:|::.:: |...:.
Human   479 WDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITIT-VRGRNV 542

  Fly   531 KVTQQRFLSNPASYEEAPSDSA--YGYKWSVPITWFADDGSENSFIYDY------DVDSVGIAVP 587
            .:.|:.::..        ||.|  .||.|.||:|:..   |::..::.:      ||    :.:|
Human   543 HMKQEHYMKG--------SDGAPDTGYLWHVPLTFIT---SKSDMVHRFLLKTKTDV----LILP 592

  Fly   588 SEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIP 652
            .||:|||.||...|||.|:||:..|..|...|..:.......||..|:|:||.|....:||.:..
Human   593 EEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKA 657

  Fly   653 LDMTAYLAQERDFVPWYVASNKLRSLHRSLM----FSEGYVSYLTYARSLIAGVYEEVGWTVDAD 713
            ||::.||..|.:.:|.:...|:|..::: ||    .:|....:..:...|:..:.::..|| |..
Human   658 LDLSLYLKHETEIMPVFQGLNELIPMYK-LMEKRDMNEVETQFKAFLIRLLRDLIDKQTWT-DEG 720

  Fly   714 NHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSP-DLREIVYYYGMQQSTSQSSW 777
            :..:..||..:|..||......|:|:|...|..:.|:......| |:...|:..|.|   |...|
Human   721 SVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQ---STEGW 782

  Fly   778 DQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESI----VRSQDYFTCVQYIAAN 838
            |.|:..:.....::||.::.:.|...:|.:.|     |...|||.    :::|::...:..|..|
Human   783 DFLYSKYQFSLSSTEKSQIEFALCRTQNKEKL-----QWLLDESFKGDKIKTQEFPQILTLIGRN 842

  Fly   839 PVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANS 903
            |||.|:.|:|.|:.|.:|..:|.|.:.:...::...|..|::..:||||:.|||...|:|:....
Human   843 PVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRC 907

  Fly   904 RLEAVETIKYNIEWLSRNEADITDWL 929
            ..:.:|||:.||.|:.:|...|..||
Human   908 VQQTIETIEENIGWMDKNFDKIRVWL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	170/394 (43%)
		M1_APN_2	75..518	CDD:189008	189/476 (40%)
		ERAP1_C	593..910	CDD:288671	90/325 (28%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	189/476 (40%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	93/328 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820