Protein Alignment CG8774 and Lvrn

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: XP_038953135.1
• Gene: Lvrn / 502160
• RGDID: 1562779
• Length: 987
• Species: Rattus norvegicus
• Alignment Length: 1018
• Identity: 291/1018 - (28%)
• Similarity: 476/1018 - (46%)
• Gaps: 134/1018 - (13%)

  Fly     2 FLSGYWLQ----VVLSWAVVAFATATVVVA--------VQKAQLERDL-RDVQDKIDVFEEWS-- 51
            |.||.::.    ::|:........|.||:|        ||.::|:..| :|........:||:
  Rat     5 FSSGIYVSRGVALLLAGLTAVLLLALVVLAALYGSCAHVQSSELDSHLVKDTSLSPPGGQEWTQP 69

  Fly    52 --------GESRTRMKREDTTDY-RLPTNLVPTHYELYWHPDLETGN-------FTGQQRISIKV 100
                    |.|:.........|: |||..|||.||:|...|.|:..|       |||:..|:::.
  Rat    70 TPAHESTVGTSQDWRPPSGPWDHLRLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRC 134

  Fly   101 VEATNQIILHSYLLDITSVYV--------LNREVEKFELEE-----ERQFLIITLTEELAVDASI 152
            ..||:.::|||:.|:...|.|        .|..|.:..||.     :.|::::.|.:.|...:|.
  Rat   135 TVATSTLLLHSFFLNYKQVEVWGPLAPDTRNATVGRVPLENVWFALDMQYVVLDLGQSLDPGSSY 199

  Fly   153 TLGIIFGGQ-MKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVH 216
            .|...|.|| :::...||:.:.|.:| ...|.:..|:.|||:||..||||||||:||||.||::|
  Rat   200 ELNFDFSGQVLQEGSEGLFLNLYTDE-DQLRALIATQMEPTFARHVFPCFDEPALKATFNITIIH 263

  Fly   217 PSGSYHAVSNMQQTESNYLGD-----YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGED 276
            ..| |.|:|||.|...::..|     :|...|.|:..|.||||.:::.||...|.|.:    |::
  Rat   264 HPG-YVALSNMPQLGQSHRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDYVSRTER----GKE 323

  Fly   277 FSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRE 341
            ..:.|.........::||......|..:....:.:.|||.|.|:.|:|.|.:||||:|||:.: :
  Rat   324 IRVWARKDDIADGYLDFAANHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIF-D 387

  Fly   342 TALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDW 406
            .:||.:........:..|...|:||:.||||||||||.|||::|||||||.|.:....|..:|..
  Rat   388 ASLLLELDDDLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPKV 452

  Fly   407 GMLEQFQIVALQPVLLYDAKLSSHPIVQKVES---PDEITAIFDTISYEKGGSVIRMLETLVGAE 468
            .....|.:..|..:|..|..|.|..:...||:   ..||..:||..:|:||..:..||...:...
  Rat   453 PRNMIFFLTVLHDILEDDHSLESRAVSTPVENFTETREINRLFDIYTYKKGACMAWMLAGFLSQH 517

  Fly   469 KFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDI-------KKLMLTWTEQMGYPVLNVSKVA 526
            .|..|:.:||....::|...||....::..:.:..|       |::|.:||.|.|:||:.:
  Rat   518 LFINALKSYLETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITL---- 578

  Fly   527 DGSFKVTQQRFLSNPASYEEAPSDSAYGYK-WSVPITWFADDGSENSFIYDYDVDSVGIAVP--- 587
            :.|..|.:|    .|...|...:.:...:. |.|||.|. .:|.....::   :|...:..|
  Rat   579 NASTGVVKQ----EPFYLERVENQTLLSHNTWIVPIFWM-KNGITQPLVW---LDKSSMIFPGMK 635

  Fly   588 ---SEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSY 649
               |:..|:.||.|.||||||||::..|..|.|||...|....:.:|..|::|||||:..|.:..
  Rat   636 LSDSDSDWVILNFNVTGYYRVNYDKLGWKKLNQQLEKDPKAIPVINRLQLVSDAFALSKNNYIEI 700

  Fly   650 KIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFS-EGYVSY-------LTYARSLIAGVYEEV 706
            :..||:|.|:|:|.:.:.|:.....|  ::|.:::. :.|..|       |....|:
  Rat   701 ETALDLTKYIAKEDEILVWFEVLVNL--INREVVYDVKNYYLYPLLKKYFLKRLNSI-------- 755

  Fly   707 GWTVDA-----------DNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLR 760
             ||:.:           ||.|...........||.||:.||||.:.|.|..::.:|.|...|.:.
  Rat   756 -WTIYSAIIRENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWMAHPETAIPPQIE 819

  Fly   761 EIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKL-KLMYGLSGVRNSQYLFDFLAQASSDESIVR 824
            ::|....:... |...||.||.|::.:|:..|.| .|::.:...::.:.|..|:   ..|.::..
  Rat   820 KVVLCNAIALG-SNKDWDFLFNLYINKTEEQEDLFHLVHAMGCSKDPRTLNRFM---EYDITVFP 880

  Fly   825 SQ-DYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQ 888
            |: :....::.:|.:.||..|..:|....|..:..|:|..:.|  .|::.:....::..::.|:|
  Rat   881 SRFNETNLIEVVAESEVGRYVAKDFLINNWVAVYERYGPQSLN--TLVSILGRTVSTDQQVMELQ 943

  Fly   889 HFFSKYPESGAG--ANSRLEAV--ETIKYN------IEWLSRN 921
            .|.|...|....  |:::|:.:  |.:|..      :|||.:|
  Rat   944 QFLSTVLEEHQRIVAHAKLQEMKAENLKNKKRIARVVEWLRKN 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	153/473 (32%)
		ERAP1_C	592..912	CDD:463368	90/344 (26%)
Lvrn	XP_038953135.1	M1_APN-Q_like	102..569	CDD:341064	153/473 (32%)
		ERAP1_C	643..948	CDD:463368	85/321 (26%)