DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and lta4h

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001006898.1	Gene:	lta4h / 448745	XenbaseID:	XB-GENE-955977	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	121/501 - (24%)
Similarity:	204/501 - (40%)	Gaps:	96/501 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYV----L 122
            |.:.:..|......|..|..|.|..:...|....::::.::.:    |.|.:||...:.:    :
Frog     3 DPSSFASPEKFNIKHMNLKLHVDFASCVITASTSLTVRSLQDS----LASLILDTKDLTIKKVAV 63

  Fly   123 NREVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSST--------YL---N 176
            |.:..||.|.....|....|  |:.:..|:|.|       :|.:|.:.|.|        :|   .
Frog    64 NGKDAKFALGTSHSFKGTPL--EITLPFSLTRG-------QDVIVEIDSVTSPKSSALQWLTAEQ 119

  Fly   177 EAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEA 241
            .||.......::.:.|:.|...||.|.|::|.|:...|..|......:|.::..|.....|.:..
Frog   120 TAGKVHPYLFSQCQATHCRSIIPCQDTPSVKFTYCSQVSVPKELVALMSALRDGELVEQNDCSRK 184

  Fly   242 I--FETSVSMSTYLVCIIVSDFASQS----TTVKANGIGEDFSMQAYATSHQINKVEFALEFGQA 300
            |  |..:|.:.:||:.::|.....:.    ||:...  .|......|             ||.:
Frog   185 IYCFMQNVPIPSYLIALVVGALEGRKGGPRTTIWTE--KELLEPSVY-------------EFSE- 233

  Fly   301 VTEYYIQYYK---VPYPLTKLDMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAG 361
             ||..::|.:   .||...:.|:..: |.|..|.||:..|.....|.|         |..:|:||
Frog   234 -TEKMLKYAEDLVGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVL---------AGDRSLAG 288

  Fly   362 TLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQF-QIVAL-------Q 418
            .:||||:|.|.|||||.:.|.:.|||||...|::.:....:|.     |:| |..||       .
Frog   289 VIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRIDGLLHG-----EEFRQFKALGGWKELQN 348

  Fly   419 PVLLYDAKLSSHPIVQKVESPDE--ITAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYLVK 480
            .|..:.|   ::|:...|.:..|  :.|.|.::.||||.:::..||.|:|. |.|...:.:|:..
Frog   349 SVNTFGA---TNPLTNLVPNLHEVDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQM 410

  Fly   481 HQFNNTVTDD--------FLTEVEAVVTDLDIKKLMLTWTEQMGYP 518
            ..:.:..|:.        |..:|: ::..:|.|    .|....|.|
Frog   411 FAYKSVTTEQWKNFLYSYFKDKVD-ILDKVDWK----GWMHTPGMP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	103/421 (24%)
		M1_APN_2	75..518	CDD:189008	118/486 (24%)
		ERAP1_C	593..910	CDD:288671
lta4h	NP_001006898.1	leuko_A4_hydro	3..604	CDD:274120	121/501 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000