DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and CG11951

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	289/928 - (31%)
Similarity:	468/928 - (50%)	Gaps:	68/928 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 WSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETG---NFTGQQRISIKVVEATNQIILHS 111
            ::||..|      ...:||||.|.|..|::.....||..   :|.|..:|.|:|::.|:.|.|||
  Fly    15 FAGEGST------YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHS 73

  Fly   112 YLLDITSVYVLNREVEKFELEEE----------RQFLIITLTEELAVDASITLGIIFGGQMKDKL 166
            ..|.|....:...::...|..|.          ..|.|:...:||.......|.:.|..:::|:|
  Fly    74 KDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQL 138

  Fly   167 VGLYSSTYLNE-AGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQT 230
            .|.|.|:|:|. |..||.||.|:|||..||.||||||||..||:||||:.:.. .|..:|||...
  Fly   139 AGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHK-KYTGLSNMPVN 202

  Fly   231 ES---NYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVE 292
            |:   ..:.||....||.|:.||||||...::||:.:.:|: .||.    ..:.:|..:.|::.:
  Fly   203 ETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTL-PNGT----LFRTWARPNAIDQCD 262

  Fly   293 FALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQ 357
            :|.|.|..|.:||.:.:.:.:||.|:|..|:|||::||||:|||||:.|:.|||.|.|||...||
  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327

  Fly   358 SIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLL 422
            ..|..:|||:||||||||||||||.|||||||||.|:....|..:||.|..|:...:..|..:..
  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392

  Fly   423 YDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTV 487
            .|:..|||||.:.:|...:|:..||.|||:||.|||||:...:|.|.|...:.:||.|:.:.|..
  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457

  Fly   488 TDDF---LTEVE----AVVTDLDIKKLMLTWTEQMGYPVLNVSK-VADGSFKVTQQRFLSNPASY 544
            .|:.   ||:..    ::..|.:||.:|.:||.|.||||:||:: ....:.|::|:|:|.|
  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLN---- 518

  Fly   545 EEAPSDSAYGYK--WSVPITWFADDGSE--NSFIYDY-DVDSVGIAVPSEV-------QWIKLNV 597
                :|.:..:|  |.||:::...:..:  |:...:: :....|.:||..:       ||:..|.
  Fly   519 ----TDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNN 579

  Fly   598 NQTGYYRVNYEESLWALLIQQLTTSPAR-FEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQ 661
            ..:..|:|||:...|.|||:.|.:.... ..:.:|..|::|....|...:..|:|.|.:.:||.:
  Fly   580 QLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLER 644

  Fly   662 ERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDA----DNHLKNRLRV 722
            ||:.:||..|.:.|:.:...|..:..:..:..:.|.||..:||.:....|.    :...|..|:.
  Fly   645 ERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKA 709

  Fly   723 SILTAACALGVPDCLQQASERFSTFLE--NP-TTRPSP-DLREIVYYYGMQQSTSQSSWDQLFQL 783
            .:...||:..|.||:.||...:.::..  || ...|.| .:|.:||...::....: .||.|:..
  Fly   710 IVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDE-DWDFLWTR 773

  Fly   784 FVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEF 848
            :.....|:||..::..|...:....|..:|.:.......:|.||..:..|.||.:.||..:..::
  Fly   774 YQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKY 838

  Fly   849 YREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRL-EAVETIK 912
            ..:....::..:...:.:...|:..::....:....:|..:|.:...:........: :::||:.
  Fly   839 LMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETML 903

  Fly   913 YNIEWLSRNEADITDWLS 930
            .|::|..||....|..:|
  Fly   904 INVQWKERNYERFTRAIS 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	164/403 (41%)
		M1_APN_2	75..518	CDD:189008	183/466 (39%)
		ERAP1_C	593..910	CDD:288671	68/326 (21%)
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	180/460 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	70/328 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.920