DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and CG42335

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	258/922 - (27%)
Similarity:	433/922 - (46%)	Gaps:	86/922 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DTTDYRLPTNLVPTHYEL---YWHPDLETGNFTGQQRISIKVVEA--TNQIILHSYLLDITSVYV 121
            :..||||..::||:||.|   .....:|...|.|:..|:::||..  ..|||||:..||||..::
  Fly    21 NAADYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWL 85

  Fly   122 LN---REVEKFEL-----EEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYL-NE 177
            |:   .:||..::     |...|.:.:.|||......:.|||..:.|.::..:.|.:|::|: .:
  Fly    86 LDAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERD 150

  Fly   178 AGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD--YTE 240
            ...||.::.|:.:...||...|||||||:||.|.:.:|.|:| |.:::|.:..|:..|..  :.:
  Fly   151 TNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNG-YQSIANTKLKETKALSQDRFVD 214

  Fly   241 AIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYY 305
            ...||.| |||||:..:|::::::         |.:............:..||:...||.|...|
  Fly   215 HFKETPV-MSTYLLAFMVANYSAR---------GNESEFAVLTRPEFYDNTEFSYHVGQQVVSAY 269

  Fly   306 IQYYKVPYPLTKLDM---AAIPDFASGAMEHWGLVTYRETALLYDPSYSST-ANKQSIAGTLAHE 366
            .:.::.||.....|:   |:.|.|....||:|||:.|.:..|:.:|.||.. ::|:.....:|||
  Fly   270 GELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHE 334

  Fly   367 IAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHP 431
            .:|.|||:.||..||:..||||.||||.:|...:.::||:.:.|||.:..:|.:...||:..:.|
  Fly   335 TSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQP 399

  Fly   432 IV---QKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDF-- 491
            :.   .::::|.:|...|..|:|.||..::||...|:|||.|:.|:.:||.::...|||..:.
  Fly   400 MTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFY 464

  Fly   492 -LTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVT--QQRFLSNPASYEEAPSDSAY 553
             |.|......|:|:...:..:|||:|||:: :.|...|:..||  |.|||.|......|.
  Fly   465 HLFEHWPKNQDVDLVDFLTDYTEQVGYPMI-IVKALQGNKVVTVEQSRFLLNKDDGSNAT----- 523

  Fly   554 GYKWSVPITWFADDGSENSFI----YDY---DVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESL 611
             .|::||||:..:  .|..|.    |.|   .|:.:.:...|.:.||..|:.|:.|.||.|:::|
  Fly   524 -LKYTVPITFTTN--LERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTL 585

  Fly   612 -WALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKL 675
             ..||:....|:.:...:.:|..:::|.|..|.|..:.|........|||:|.::||||.....|
  Fly   586 REGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENL 650

  Fly   676 RSLHRSLMFSEGYVSYLTYARSLIAGVYEE--VGWTVDADNHLKNRLRVSILTAACALGVPDCLQ 738
            .::.:.|. .|....:..|..|:.|.|:|:  |||... |..|....|..::...|.....:|..
  Fly   651 NTVAKRLT-PEQLPDFRIYLSSITAAVFEKLGVGWNAQ-DTPLDVANRNKLIKWLCRYQASNCRP 713

  Fly   739 QASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGV 803
            :.:.:|.|..|    .||||.||.  :|........:|:..|:..:..|...|||..|...:|..
  Fly   714 KVNVQFVTGHE----VPSPDYRET--FYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCT 772

  Fly   804 RNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFG 868
            |:.:..:..:. .|..||:  .|......:....||.....::|...|...:|...|...:..
  Fly   773 RDYETHYHKMI-ISGTESV--EQKKIGIARMYEENPDLVQAIFEMITENIMELAYNFQSWSDT-- 832

  Fly   869 RLIAQITANFASSVKLEEVQH-----FFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDW 928
               |::..:.|......|.|.     ::|.:...|.......:::.|::.|:.|...:
  Fly   833 ---AEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETH------- 887

  Fly   929 LSGTASPLTKKN 940
            |.|....|..:|
  Fly   888 LEGLVKYLADRN 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	126/409 (31%)
		M1_APN_2	75..518	CDD:189008	145/468 (31%)
		ERAP1_C	593..910	CDD:288671	76/324 (23%)
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	126/409 (31%)
		M1_APN_2	34..492	CDD:189008	145/468 (31%)
		ERAP1_C	567..874	CDD:288671	76/322 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020