DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and CG31233

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	971	Identity:	290/971 - (29%)
Similarity:	490/971 - (50%)	Gaps:	85/971 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSGYWLQVVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTDYR 67
            :.|..:.:||..|:    :||....|::..:...|:.:::.:         .|..:...|..:||
  Fly     6 VGGMSVFLVLLLAI----SATQAAVVRQYPILDHLQHLENPM---------QRLVVPLADEDNYR 57

  Fly    68 LPTNLVPTHYELYWHPDLETGN--FTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEK-- 128
            ||.:.:|:||.:....::.||:  |.|...|::.|:..|.:|::|:..|:..:..::.:.|.:
  Fly    58 LPYDTIPSHYAVSLSTNVHTGDTVFNGTVAITLSVLNTTTKIVVHARQLENFTASIIQQGVTEAV 122

  Fly   129 -----FELEEERQFLIITLTE-ELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTT 187
                 :|.|.||:||..:.|. ....|.:..|.|.:.|.::....|.|.|||.:|.|.|:.::||
  Fly   123 AQELVYEYEAEREFLTFSKTGLTFPEDTTWILTINYQGHLRTDNGGFYLSTYTDEEGNTKYLATT 187

  Fly   188 KFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSVSMSTY 252
            :||.|.||.||||:|||:.:|.|.||:.| ..||:|:|||....|:..|   ..:|:.:|:|.:|
  Fly   188 QFESTDARHAFPCYDEPSKRAEFTITIKH-DPSYNAISNMPVDSSSTSG---VTVFQKTVNMPSY 248

  Fly   253 LVCIIVSDFASQSTTVKANGIGED-FSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLT 316
            ||..|||:|.....  :.||:.:. ||..  .|.|:   .|:||..|..|.:....|:.||:.|.
  Fly   249 LVAFIVSEFVFSEG--ELNGLPQRVFSRN--GTEHE---QEWALTTGMLVEKRLSGYFDVPFALP 306

  Fly   317 KLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWW 381
            |||.|.|||||:||||:|||.||||..|||:...|:|:.:.:||...|||.||.|||:||.::||
  Fly   307 KLDQAGIPDFAAGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWW 371

  Fly   382 NDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIF 446
            :.|||.||||...:...|:..:|:|.:.:.|...:.|..|:.||..::.|:...|:.|.||..::
  Fly   372 SFLWLKEGFATLFENLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMSHFVQKPSEIALLY 436

  Fly   447 DTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQF-------------NNTVTDDFLTEVEAV 498
            |::||.|.|||:.|....:....|:..:.||||.:||             ...|.:::  ||:|.
  Fly   437 DSVSYAKAGSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSKLFEAIAKAAVEENY--EVKAT 499

  Fly   499 VTDLDIKKLMLTWTEQMGYPVLNVSKVAD-GSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPIT 562
            |.|     :|.:||.|.|.|:|.|::..| |||.|.|..:.::        .|......|.|||.
  Fly   500 VPD-----MMGSWTNQGGVPLLTVTRNYDNGSFTVKQSVYTND--------KDYTNDKLWYVPIN 551

  Fly   563 WFADDGSE--NSFIYDYDVDSVGIAVPSEV---QWIKLNVNQTGYYRVNYEESLWALLIQQLTTS 622
            :......:  |:....|.::...|.:.|::   .|:.||...||||||.|:...:.|:...|.|.
  Fly   552 YAESKNPDFRNTEATHYLLNQSEITIYSDLDQTNWLILNKKSTGYYRVLYDAQNYQLITSALITR 616

  Fly   623 PARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEG 687
            |.:.:..:|..|:||.:..|.:.::.:...|::..||.||..:.||...:..:..|:|.|.....
  Fly   617 PHKIDPRNRAQLINDLYRFATSGRVPHATLLELLTYLPQEDQYSPWSATNTVITLLNRYLSGDAD 681

  Fly   688 YVSYLTYARSLIAGVYEEVGWTVD-ADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENP 751
            |.::..|.|.|::..:::.|...: .|:||....|..::..||..|:.:||.:.:.:.:..:|.
  Fly   682 YGNFQFYVRELVSLQFDKFGVNDNKGDHHLVPFTRNVLINLACLAGLENCLTETTAKLTALVEE- 745

  Fly   752 TTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQA 816
            .|:..|:|:..||..|::|: ...::|.:|...:..||.:|:..|:..|...:|:..|..|:..:
  Fly   746 GTKIEPNLQSQVYCNGLKQA-DDKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSS 809

  Fly   817 SSDESIVRSQDYFTCVQYI-AANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRL------IAQI 874
            ...|.: |.|:..|.:..: :...||..|..||.::.|    .::|..|..||.:      |..|
  Fly   810 IEPEGL-RDQERITVLSPVYSRGEVGLLVAIEFLQKNW----EKYGQLNSGFGGVNPLYSDIVGI 869

  Fly   875 TANFASSVKLEEVQHFFSKYPESGAGANSRLEAVET-IKYNIEWLSRNEADITDWLSGTAS 934
            :|...:..:.:.:|........|....::..::|:: :..|..||:.|...:..|::|..|
  Fly   870 SAYTVNDKQKDALQELVDTVKGSEYVPSTLQDSVDSNVNANYAWLASNRDPLMTWVAGFRS 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	150/397 (38%)
		M1_APN_2	75..518	CDD:189008	169/466 (36%)
		ERAP1_C	593..910	CDD:288671	80/324 (25%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	150/396 (38%)
		M1_APN_2	65..514	CDD:189008	169/466 (36%)
		ERAP1_C	587..905	CDD:288671	80/324 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462053
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.940