DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and CG8773

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster

Alignment Length:	993	Identity:	484/993 - (48%)
Similarity:	642/993 - (64%)	Gaps:	68/993 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLSGYWLQVVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTT- 64
            |.::...:.:.|..|:.||..:|:|:|||||.|:.||||.|:|:|:.|  :|.:.|......:|
  Fly     1 MIVTAKLVAIGLGLALTAFTVSTIVLAVQKANLKSDLRDAQEKLDLLE--AGYTSTAAPTTASTA 63

  Fly    65 --------------------------------------------------------DYRLPTNLV 73
                                                                    |||||..|.
  Fly    64 NPGSTASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLK 128

  Fly    74 PTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFELEEE---- 134
            ||||:||..|::|||.|:||:.|:|.|.|||:||:|||..|:|:||.::|...:..|:.|.
  Fly   129 PTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDTLEILETTVDA 193

  Fly   135 -RQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAF 198
             |:|||..|.|.|....::.|.|.|.|.|.:|:||||||:|:.|....:.|:|:|||||||||||
  Fly   194 VREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAF 258

  Fly   199 PCFDEPAMKATFAITVVHPSG-SYHAVSNMQQTESNYLGDYTEAIFETSVSMSTYLVCIIVSDFA 262
            |||||||:||.|.||:||||| .|||:|||....|...|.:.|..|..||.|||||.|.||||||
  Fly   259 PCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQEVTFAKSVPMSTYLACFIVSDFA 323

  Fly   263 SQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFA 327
            .:..::...||||.|||..|||..|::||:.|:..|:.|.||||.|:::.|||.||||||||||.
  Fly   324 YKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFV 388

  Fly   328 SGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFAR 392
            |||||||||||||||:||||.:.||..|||.||..:|||.||.||||||||.||||||||||||.
  Fly   389 SGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFAS 453

  Fly   393 YMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSV 457
            :::|.||:||:|:|.|.:||.:..|..||..|..|.||||:|.||:||:||.|||||:|.||.|:
  Fly   454 FVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSL 518

  Fly   458 IRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNV 522
            :||||..:|...|.:||||||.:::::...|.:|.||::.:....::.::|||||.|||.||:.:
  Fly   519 VRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKLELGYNVTEIMLTWTVQMGLPVVTI 583

  Fly   523 SKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDY-DVDSVGIAV 586
            .||:|..:|:||:||||||..|:.....|.:.|:||:|||:|....|....::.| |...:.:.|
  Fly   584 EKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEITVTV 648

  Fly   587 PSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKI 651
            |:.|:|||.|.:|.|||||||:..||..|..||...|:.|...||.|||||||||||:.||.|..
  Fly   649 PAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYAT 713

  Fly   652 PLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADNHL 716
            ..::|.||.:|.|:|||.||:::|.||.|:|.::..|..|..||.:||..:|..:.|||..| ||
  Fly   714 AFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTWTVGED-HL 777

  Fly   717 KNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLF 781
            .|||||:.|:|||:||:..||.:|.|:|:.:|..|..||..|:||.|||||:|...||..||.::
  Fly   778 DNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVW 842

  Fly   782 QLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVW 846
            :|||.|:|||||.|||||||.::....|..::..|.::| .||.||||||:.||:||||||.:||
  Fly   843 ELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEE-YVRGQDYFTCLTYISANPVGESLVW 906

  Fly   847 EFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETI 911
            ::.||.|.:|..|||||.|..|.||..|||.|::..||||::.||:||||:|||..:|:.|:||:
  Fly   907 DYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETV 971

  Fly   912 KYNIEWLSRNEADITDWL 929
            |.||.||:.|...:..||
  Fly   972 KNNIVWLAENLEGVDAWL 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	227/392 (58%)
		M1_APN_2	75..518	CDD:189008	249/448 (56%)
		ERAP1_C	593..910	CDD:288671	164/316 (52%)
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	227/392 (58%)
		M1_APN_2	130..579	CDD:189008	249/448 (56%)
		ERAP1_C	655..969	CDD:288671	164/315 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468261
Domainoid	1	1.000	261	1.000	Domainoid score	I1917
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	633	1.000	Inparanoid score	I811
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1044at33392
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm26111
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
	13	12.830