DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and npepps

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	896	Identity:	303/896 - (33%)
Similarity:	455/896 - (50%)	Gaps:	61/896 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLD-ITSVYV------LNR 124
            ||||::.|.:|.|...|||....|.|:...:::|.:.||||:::...:| ||:.:|      :|.
Zfish     9 RLPTDVYPVNYGLRLKPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDIITASFVPDGGEEINA 73

  Fly   125 EVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKF 189
            ....::.|:|:..|....|.:   ..|.:|.|.|.|::.||:.|.|.|.| :.:|..|..:.|:|
Zfish    74 TGFNYQNEDEKVTLCFPSTLQ---KGSGSLKIDFVGELNDKMKGFYRSKY-SSSGEVRYAAVTQF 134

  Fly   190 EPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESN-YLGDYT--EAIFETSVSMST 251
            |.|.||:||||:||||:||||.||::.|.... |:|||...:.. |..|.:  |..|.|:..|||
Zfish   135 EATDARRAFPCWDEPAIKATFDITLIVPKDRV-ALSNMNVVDRKPYAEDQSLVEVKFATTPIMST 198

  Fly   252 YLVCIIVSDF---ASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPY 313
            |||..::.::   .|||    ::|:    :::.|....:..:.:||||.......:|..|:.|||
Zfish   199 YLVAFVIGEYDFVESQS----SDGV----TVRVYTPVGKAEQGKFALEVATKTLPFYKDYFSVPY 255

  Fly   314 PLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTM 378
            ||.|:|:.||.|||:||||:||||||||||||.||..|..:::|.:|..:.||:|||||||||||
Zfish   256 PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFGNLVTM 320

  Fly   379 KWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEIT 443
            :||..||||||||.:::|..|:...|::.:..||........|..||..:||||...|..|.|:.
Zfish   321 EWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVDVGHPSEVD 385

  Fly   444 AIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLM 508
            .|||.|||.||.||||||...:|.|.|.:.:..||:|.|..|..|:| |.|.....:...|..:|
Zfish   386 EIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTED-LWECLEQASGKPIAAVM 449

  Fly   509 LTWTEQMGYPVLNVSKVADGS---FKVTQQRF-LSNPASYEEAPSDSAYGYKWSVPIT-WFADDG 568
            .:||:|||:|::.|.:...||   .|::|::| .|.|.:.|:.|:       |.|||: ..::|.
Zfish   450 NSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASGPRNDEDCPN-------WMVPISICTSEDP 507

  Fly   569 S--ENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALL---IQQLTTSPARFEI 628
            |  :...:.|....:|.|...:...|||:|....|:||:.|..::...|   |:.||..|
Zfish   508 SCTKTKILLDQPETTVNITNVAPDHWIKINPGTVGFYRIQYSSAMLESLLPGIRDLTLLP----- 567

  Fly   629 ADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLT 693
            .||..|.||.|:||.|..:|....|.:......|.::..|...|..|..|...|..::.:.....
Zfish   568 VDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLLSHTDFHEDIQE 632

  Fly   694 YARSLIAGVYEEVGW-TVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSP 757
            :.|.|...:..::|| :...:.||...||..:|......|....|::|..||...:|..... |.
Zfish   633 FIRDLFTPIGMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFREHVEGKQIL-SA 696

  Fly   758 DLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESI 822
            |||..||...::...| ::.|.:.:|........||.::...|..:.....:...|..|.|:|
Zfish   697 DLRSPVYLTVLKHGDS-TTLDTMLKLHKQADMQEEKNRIERVLGAIPAPDLIQRVLNFALSEE-- 758

  Fly   823 VRSQDYFTCVQYIA-ANPVGEPVVWEFYREQWPQLTTRFGLNNRNF--GRLIAQITANFASSVKL 884
            ||.||..:.:..:| ::..|....|:|.::.|.:|..|:   ...|  .|||......||.....
Zfish   759 VRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHNRY---QGGFLISRLIKLTVDGFAIDKMA 820

  Fly   885 EEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWLSGTASP 935
            .||:.||..: .:.|...:..:..|.|..|..||.|:..||..:|....:|
Zfish   821 AEVKSFFESH-HAPAAERTVQQCCENILLNAAWLKRDADDIHQYLLQRKTP 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	163/399 (41%)
		M1_APN_2	75..518	CDD:189008	185/455 (41%)
		ERAP1_C	593..910	CDD:288671	82/323 (25%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	163/399 (41%)
		M1_APN_2	17..459	CDD:189008	185/455 (41%)
		ERAP1_C	534..845	CDD:288671	82/323 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820