DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8774 and lta4h

DIOPT Version :10

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_998451.1 Gene:lta4h / 406575 ZFINID:ZDB-GENE-040426-2477 Length:611 Species:Danio rerio


Alignment Length:568 Identity:131/568 - (23%)
Similarity:219/568 - (38%) Gaps:133/568 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 HYELYWHPDLETGNFTGQQRISIKVVE-ATNQIILHSYLLDITSVYVLNREVEKFELEEERQF-- 137
            |..|.:|.|.:.....|:..::::|:| ..:.:.|.|..|.|:.|.. |.:..||||..:.:|  
Zfish    20 HLNLIYHVDFDRHVLKGKVALTVEVLEDKFSSLTLDSKDLKISKVSA-NGQAAKFELGAKHKFKG 83

  Fly   138 --LIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPC 200
              |.|||..||:....:.:.|.:  :.......|...|....||.......::.:.|:.|...||
Zfish    84 SPLEITLPFELSRGQHVIVEIEY--ETSPTATALQWLTPKQTAGKKHPYLFSQCQATHCRTMVPC 146

  Fly   201 FDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAI--FETSVSMSTYLVCIIVSDFAS 263
            .|.|::|.|:...|..|......:|.::..:.....|.:..|  |...|.|.:||:.|:|....|
Zfish   147 QDTPSVKHTYYAQVSVPRELVALMSALRDGQEPDPSDSSRVIYRFRQPVPMPSYLIAIVVGALES 211

  Fly   264 QSTTVKANGIGEDFSMQAYA--TSHQINKVEFALEFGQAVTEYYI--QYYKVPYPLTKLDMAAIP 324
            :....::    ..:|.:.|.  .:::..:.|..|:..:::...|:  ||..:..|         |
Zfish   212 REIGPRS----RVWSEKEYVDEAAYEFAETETMLKTAESLAGPYVWGQYDVLVLP---------P 263

  Fly   325 DFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEG 389
            .|..|.||:..|.....|.|         |..:|:||.:||||:|.|.|||||.:.|...|||||
Zfish   264 SFPYGGMENPCLTFVTPTVL---------AGDRSLAGVIAHEISHSWTGNLVTNRTWEHFWLNEG 319

  Fly   390 FARYM--------------QYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPD 440
            ...|:              |:||:..    |..|.       :.|..:.|......:|..:...|
Zfish   320 HTVYIERMIARCMEGEQLRQFKGIGG----WKELH-------ESVKQFGANNVLTNLVPNLHEVD 373

  Fly   441 EITAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYLVKHQFNNTVTD--------------D 490
            ...| |.::.||||.:::..||.|:|. |.|...|.:|:....:.:..|:              |
Zfish   374 TDEA-FSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLFAYGSVTTEEWKNYLFTYFKDKVD 437

  Fly   491 FLTEVE----------------------------------------AVVTDLDIKKL-------- 507
            .|.:|:                                        |..|:.|:|:|        
Zfish   438 ILNKVDWNAWMHTPGMAPVRPQYDTTMADACTSLCQKWVKAKEADLASFTEADVKQLNSPQLIEF 502

  Fly   508 MLTWTEQMGYPVLNVSKVAD----GSFKVTQQRF----LSNPASYEEA 547
            |....::...|:.:|.|:.:    .:.|..:.||    :...|.:|||
Zfish   503 MALLLQEDPLPLSHVKKMGEVYKLNNIKNAEVRFRWLRICVKAQWEEA 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 M1_APN-Q_like 75..513 CDD:341064 121/524 (23%)
ERAP1_C 592..912 CDD:463368
lta4hNP_998451.1 leuko_A4_hydro 18..607 CDD:274120 131/568 (23%)
Blue background indicates that the domain is not in the aligned region.

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