DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8774 and LTA4H

DIOPT Version :9

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_000886.1 Gene:LTA4H / 4048 HGNCID:6710 Length:611 Species:Homo sapiens


Alignment Length:648 Identity:142/648 - (21%)
Similarity:244/648 - (37%) Gaps:147/648 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 DTTDYRLPTNLVPT-HYELYWHPDLETGNFTGQQRISIKVVEAT-NQIILHSYLLDITSVYVLNR 124
            ||.....|.::..| |..|....|......||...::::..|.. ..::|.:..|.|..|.:..:
Human     6 DTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQ 70

  Fly   125 EVEKFELEEERQF----LIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTIS 185
            || |:.|.|.:.:    :.|:|...|:.:..|.:.|.|  :...|...|...|....:|......
Human    71 EV-KYALGERQSYKGSPMEISLPIALSKNQEIVIEISF--ETSPKSSALQWLTPEQTSGKEHPYL 132

  Fly   186 TTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFE--TSVS 248
            .::.:..:.|...||.|.|::|.|:...|..|......:|.::..|:....|.:..|::  ..|.
Human   133 FSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVP 197

  Fly   249 MSTYLVCIIVSDFASQSTTVKANGIG---------EDFSMQAYATSHQINKVEFALEFGQAVTEY 304
            :..||:.::|....|:.       ||         |.....||..|...:.::.|.:.|.     
Human   198 IPCYLIALVVGALESRQ-------IGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGG----- 250

  Fly   305 YIQYYKVPYPLTKLDMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIA 368
                   ||...:.|:..: |.|..|.||:..|.....|.|         |..:|::..:||||:
Human   251 -------PYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLL---------AGDKSLSNVIAHEIS 299

  Fly   369 HQWFGNLVTMKWWNDLWLNEGFARYMQ-----------YKGVNAVHPDWGMLEQFQIVALQPVLL 422
            |.|.|||||.|.|:..|||||...|::           ::..||: ..||.|:       ..|..
Human   300 HSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNAL-GGWGELQ-------NSVKT 356

  Fly   423 YDAKLSSHPIVQKVESPDEI--TAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYLVKHQFN 484
            :.   .:||..:.|....:|  ...:.::.||||.:::..||.|:|. |.|...:..|:.|..:.
Human   357 FG---ETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYK 418

  Fly   485 NTVTDD--------FLTEVEAVVTDLDIKKLMLTWTEQMGYPVLN-------------------V 522
            :..|||        |..:|: |:..:|..    .|....|.|.:.                   .
Human   419 SITTDDWKDFLYSYFKDKVD-VLNQVDWN----AWLYSPGLPPIKPNYDMTLTNACIALSQRWIT 478

  Fly   523 SKVAD-GSFKVTQQRFLSN-------PASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDV 579
            :|..| .||..|..:.||:       ..:.:.||....:..:......:.|.:.||..|      
Human   479 AKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRF------ 537

  Fly   580 DSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLT-------TSPARFEIA--DRGH 633
                       :|::|.:..      .:|::: .|.::..|       |.|...::|  |:.|
Human   538 -----------RWLRLCIQS------KWEDAI-PLALKMATEQGRMKFTRPLFKDLAAFDKSH 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 Peptidase_M1 67..454 CDD:279741 97/417 (23%)
M1_APN_2 75..518 CDD:189008 115/482 (24%)
ERAP1_C 593..910 CDD:288671 9/50 (18%)
LTA4HNP_000886.1 leuko_A4_hydro 6..608 CDD:274120 142/648 (22%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 135..137 0/1 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 267..272 1/4 (25%)
Inhibitor ARM1 binding. /evidence=ECO:0000269|PubMed:24591641 362..365 1/2 (50%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 564..566 0/1 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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