DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and LNPEP

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	878	Identity:	296/878 - (33%)
Similarity:	462/878 - (52%)	Gaps:	34/878 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLN------RE 125
            ||||.:||..|||..||:|.:..|.|...||::.::.|..|||||...:|:.|..::      ::
Human   167 RLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQ 231

  Fly   126 VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFE 190
            .|..|.....|..|:. .|.|....:.||.|.:...:.....|.|..:|.:|:...:..:.|:||
Human   232 AEILEYAYHGQIAIVA-PEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFE 295

  Fly   191 PTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD-YTEAIFETSVSMSTYLV 254
            |..||.|||||||||.||||.|.::... .|.|:|||.:..|..|.| ..:..|..||.||||||
Human   296 PLAARSAFPCFDEPAFKATFIIKIIRDE-QYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLV 359

  Fly   255 CIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLD 319
            ..||.:..:.|..|  ||.    .:..||...:|.:|.:|||....:.|::..|:::.|||.|||
Human   360 AFIVGEMKNLSQDV--NGT----LVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLD 418

  Fly   320 MAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDL 384
            :.|||||.:||||:|||:|:||..||||.:.||.|:::.:...:|||:|||||||||||||||||
Human   419 LVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDL 483

  Fly   385 WLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTI 449
            |||||||.:|:|..:..:..:....|.| :.|....:..|:..|||||...|:|.::|..:||::
Human   484 WLNEGFATFMEYFSLEKIFKELSSYEDF-LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSL 547

  Fly   450 SYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTD-LDIKKLMLTWTE 513
            ||.||.|::.||:|.:..:.|:.||..||..|.:.:..:||.......|... ||:|::|.|||.
Human   548 SYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTL 612

  Fly   514 QMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSF--IYD 576
            |.|:|::.|.|.....| :.|:||..| ...|..|||::  |.|.:|:::..:..:.:.:  :..
Human   613 QKGFPLVTVQKKGKELF-IQQERFFLN-MKPEIQPSDTS--YLWHIPLSYVTEGRNYSKYQSVSL 673

  Fly   577 YDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFAL 641
            .|..|..|.:..||.|:|:|:|..|||.|:|.:..|..||.||..:|......||.:|:|:.|.|
Human   674 LDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFEL 738

  Fly   642 ADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVS----YLTYARSLIAGV 702
            |...::..|...|:..||..|....|...|..:...:: :|:...||:.    .:|....|:...
Human   739 AGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIY-NLLEKLGYMDLASRLVTRVFKLLQNQ 802

  Fly   703 YEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSP-DLREIVYYY 766
            .::..|| |........||.::|..||...:.:|...|.:.|..::.:..|:..| |:...|:..
Human   803 IQQQTWT-DEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKV 866

  Fly   767 GMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTC 831
            |   :.:...|..|...:::....:||.|::..|:...:.:.|: :|.::|.:....|:|.....
Human   867 G---AKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLY-WLMKSSLNGDNFRTQKLSFI 927

  Fly   832 VQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPE 896
            ::.:..:..|..:.|:|.:|.|.:|..:|.|.:.....::|..|..|::...|.|||.||....|
Human   928 IRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSE 992

  Fly   897 SGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            :........||:|.|:.||:|:.:|...:|.||
Human   993 ATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	162/393 (41%)
		M1_APN_2	75..518	CDD:189008	180/450 (40%)
		ERAP1_C	593..910	CDD:288671	80/321 (25%)
LNPEP	NP_005566.2	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding	96..101
		M1_APN_2	175..617	CDD:189008	180/450 (40%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	689..1009	CDD:314669	83/325 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5920
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820