DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and erap1b

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	928	Identity:	303/928 - (32%)
Similarity:	476/928 - (51%)	Gaps:	87/928 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREV---EK 128
            |||..:.|.||.|..||:|.:.:|||..:|.|:|::.|..|||||..|.|:|..:|:..:   :.
Zfish    46 RLPDTISPLHYNLLIHPNLTSLDFTGSVQIQIEVLQDTKTIILHSKNLQISSARLLDANIAQQQP 110

  Fly   129 FELEEERQFLIITLTEELAV---DASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFE 190
            .::.|...|..|.|..:.|:   ....::.:.|...:.:...|.|.|||....|..|.:::|:||
Zfish   111 LKVLEYPYFQQIALVSDKALLKRGHVYSVELHFAANLSESFHGFYKSTYRTSKGDVRVVASTQFE 175

  Fly   191 PTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYL-GDYTEAIFETSVSMSTYLV 254
            .|.||.|||||||||.||.|::. :.....:.|:|||.:..:..| ....|..|:.||.||||||
Zfish   176 ATSARAAFPCFDEPAFKANFSVQ-IRREAKHIALSNMPKLRTLELKNGLFEDQFDVSVKMSTYLV 239

  Fly   255 CIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTK-- 317
            ..|||||.|.|.| ..:|:    .:..||...:|::.||||:....:.::|..|:.:||||.|
Zfish   240 AYIVSDFLSISKT-SQHGV----QISVYAVPEKIDQAEFALDAAVKLLDFYDDYFDIPYPLPKQE 299

  Fly   318 ------------------LDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLA 364
                              :|:||||||.|||||:|||.||||:|||:||..||.::|..|...:|
Zfish   300 KPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLFDPHKSSASDKLGITMIIA 364

  Fly   365 HEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSS 429
            ||:|||||||||||:||||||||||||::|::..||..:|:. .:|.:.:......:..|:..||
Zfish   365 HELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPEL-QVEDYFLGKCFEAMEVDSLSSS 428

  Fly   430 HPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDF--- 491
            ||:...||:|.:|..:||.:||:||..::.||...:..:.|:..:..||..:.:.|||..:.
Zfish   429 HPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGIVKYLKHYSYQNTVNSNLWES 493

  Fly   492 LTEV-------------------EAVVT---------DLDIKKLMLTWTEQMGYPVLNVSKVADG 528
            ||.|                   .|..|         :||:|.:|.|||.|.|:|::.:: |...
Zfish   494 LTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHSEDELDVKAMMETWTLQEGFPLITIA-VKGR 557

  Fly   529 SFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSE-NSFIYDYDVDSVGIAVPSEVQW 592
            ..:::|:|:|.:    ::....|:  :.|.||:|:...|.:. :.|:.....|.  :.:|.||.|
Zfish   558 EVRLSQERYLKS----DDLSQTSS--FLWQVPLTYITSDSTTVHRFLLKTKTDV--LYLPEEVDW 614

  Fly   593 IKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTA 657
            ||.||:.:|||.|:||.|.|..||..|..:.......||..|:|:||.|....:|.....||:|.
Zfish   615 IKFNVDMSGYYIVHYEGSGWDDLITLLKHNHTALSSNDRASLINNAFQLVSVGKLPLDKALDLTL 679

  Fly   658 YLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLT----YARSLIAGVYEEVGWTVDADNHLKN 718
            ||::|.:.:|.....|:|..|:: ||.....|....    |...|...:.|:..|| |..:..:.
Zfish   680 YLSKETEIMPVTQGFNELVPLYK-LMEKRDMVELENQMKGYILQLFQKLIEQQLWT-DEGSVSER 742

  Fly   719 RLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSP-DLREIVYYYGMQQSTSQSSWDQLFQ 782
            .||..:|...|..|.|.|:..|::.|:.:.::......| |:...|:..|   :.::..||.||:
Zfish   743 MLRSYLLLFGCVRGHPPCVSNATQLFNLWRDSDGNMSLPNDVTMAVFSVG---ARTEDGWDFLFE 804

  Fly   783 LFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWE 847
            .:......|.|.::...|. .....:...::.:.|.:..::::||....|..::.||......|:
Zfish   805 KYKESMYVSMKSRIKQALM-TSPLDHKLKWMMEQSLEGELIKTQDLPYVVTSVSRNPKAYKHAWD 868

  Fly   848 FYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFS-KYPESGAGANSRLEAVETI 911
            |.:..|..|..:|.|.:.:...::..:|..:::...|.||::||| ..||:||......:|||.|
Zfish   869 FLQANWDSLIKKFDLGSHSIAHMVVGVTNQYSTREMLAEVRNFFSLLQPETGAELRCIQQAVENI 933

  Fly   912 KYNIEWLSRNEADITDWL 929
            :.||.|:.:|...:..||
Zfish   934 EENIRWMDKNLPLLKAWL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	167/413 (40%)
		M1_APN_2	75..518	CDD:189008	187/500 (37%)
		ERAP1_C	593..910	CDD:288671	87/322 (27%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	167/413 (40%)
		M1_APN_2	54..548	CDD:189008	187/500 (37%)
		ERAP1_C	615..932	CDD:288671	87/322 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820