DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and Psa

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster

Alignment Length:	947	Identity:	311/947 - (32%)
Similarity:	474/947 - (50%)	Gaps:	72/947 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AVVAFATATVVVAVQK-------AQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTDYRLPTNL 72
            |::|..:|.|:....:       .|:.|....:..|     |...|...:|.::...: |||||:
  Fly   165 AILAHTSADVIPGQDRHHPGCNYQQIRRAHTQLLSK-----EQQLEQERKMAQKAKFE-RLPTNV 223

  Fly    73 VPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFELEE---- 133
            ||.||||...|:|:...|||:..:.:.|.|.|.||.|::..:.:.|| .|:.|..|.:.|:
  Fly   224 VPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSV-ELHFECSKLKPEKIVYS 287

  Fly   134 -ERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQA 197
             |.:...:...:|:..:....|.:.|.|::.||:.|.|.|.|....|..|....|:||.|.||:.
  Fly   288 AENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRC 352

  Fly   198 FPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAI-FETSVSMSTYLVCIIVSDF 261
            |||:||||:||||.||:|.|.... |:|||...:.:.|.|....: |:.:..||||||.::|.::
  Fly   353 FPCWDEPAIKATFDITLVVPKDRV-ALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVVGEY 416

  Fly   262 ASQSTTVKANGIGEDFSMQAYATSHQINKVE---FALEFGQAVTEYYIQYYKVPYPLTKLDMAAI 323
            .      ...|..:|..:....|  .:.|.|   ||||....|..||..|:.:.|||.|:|:.||
  Fly   417 D------YVEGKSDDGVLVRVFT--PVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAI 473

  Fly   324 PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNE 388
            .||::||||:|||||||||.:|.||..:|...|||||.|:.||||||||||||||:||..|||||
  Fly   474 SDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNE 538

  Fly   389 GFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISYEK 453
            |:|.::::..|:.:.|::.:..||........|..|:..:||||...|..|.||..|||.|||.|
  Fly   539 GYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNK 603

  Fly   454 GGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTWTEQMGYP 518
            |.||||||...:|.:.|.:.:..||.:||:.||.|:|....::. .:..::..:|.:||:..|:|
  Fly   604 GASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQE-ASSKNVSDVMTSWTQHKGFP 667

  Fly   519 VLNVSKVADGS----FKVTQQRFLSNPASYEEAPSDSAYGYKWSVPI---TWFADDGSENSFIYD 576
            |::|.......    .::.|.:|.::.:..:|       ...|.|||   |.....|...:|:.|
  Fly   668 VVSVESEQTSKNQRLLRLKQCKFTADGSQADE-------NCLWVVPISVSTSKNPTGIAKTFLLD 725

  Fly   577 YDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEI--ADRGHLLNDAF 639
            .....|.:....|..|||:|....||||..|.:.    :::||..:..:.|:  .||..|::|.|
  Fly   726 KSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQE----MLEQLMPAVEKMELPPLDRLGLIDDMF 786

  Fly   640 ALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYE 704
            |:..|...|....|.:......|.::..|...:|.|.:||..:..::....:..:.|:|...|..
  Fly   787 AMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAY 851

  Fly   705 EVGWTV-DADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGM 768
            .:||.. |.:|||...||..:||...:....|.:::|..||...:......|: ||| ...|..:
  Fly   852 RLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTELLPA-DLR-TTCYKAV 914

  Fly   769 QQSTSQSSWDQLFQLFVAETDASE---KLKLMYGLSG-VRNSQYLFDFLAQASSDESIVRSQDYF 829
            .|...:..::::..|:.| ||..|   ::....|..| ::..:.:.||   |.|.|  ||:||..
  Fly   915 LQDGDEKIFNEMLDLYRA-TDLHEEQDRISRALGCCGDLKLLRRVIDF---AMSSE--VRAQDSV 973

  Fly   830 TCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNF--GRLIAQITANFASSVKLEEVQHFFS 892
            ..:..:|.||.|..:.|||::|...||..|:   ...|  .|||..:..||||..:.:||:.|..
  Fly   974 FVIVAVAINPKGRDMAWEFFKENNKQLLERY---QGGFLLSRLIKYLIENFASEERAKEVEEFLQ 1035

  Fly   893 KYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            .....|. ..:..:|||||:.|..||.|:...:..:|
  Fly  1036 VNQIPGC-ERTVSQAVETIRLNAAWLQRDREQLAIFL 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	164/395 (42%)
		M1_APN_2	75..518	CDD:189008	179/451 (40%)
		ERAP1_C	593..910	CDD:288671	90/325 (28%)
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	164/395 (42%)
		M1_APN_2	227..667	CDD:189008	179/450 (40%)
		ERAP1_C	742..1052	CDD:288671	90/325 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462056
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850