DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and CG3502

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	263/902 - (29%)
Similarity:	394/902 - (43%)	Gaps:	125/902 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DYRLPTNLVPTHYEL--YWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDI----TSVYVLN 123
            |||||.::.|.||.|  ..|.:.....|.|...|.:...|.|..|.||:..|.|    ||| |..
  Fly    27 DYRLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKNITLHAAYLKIDENRTSV-VSG 90

  Fly   124 RE---VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLN-EAGATRTI 184
            :|   |.:.|:.|...|.|:.|..||..|....|.:.|...:.|...|.|.|.|.: .......:
  Fly    91 QEKFGVNRIEVNEVHNFYILHLGRELVKDQIYKLEMHFKAGLNDSQSGYYKSNYTDIVTKEVHHL 155

  Fly   185 STTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNM-----QQTESNYLGDYTEAIFE 244
            :.|:|.||:|||||||||||:.||||.||:.:.. .|..:|.|     |..:|  |.:|.....:
  Fly   156 AVTQFSPTFARQAFPCFDEPSWKATFNITLGYHK-KYMGLSGMPVLRCQDHDS--LTNYVWCDHD 217

  Fly   245 TSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEF--------------AL 295
            |.:..|||||...|.|..:.:|                ..|...|:|.|              ::
  Fly   218 TLLRTSTYLVAFAVHDLENAAT----------------EESKTSNRVIFRNWMQPKLLGQEMISM 266

  Fly   296 EFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIA 360
            |....:..:|...:::.:||.|:|...:|.....|||:||||||.|..|..:........|.|.|
  Fly   267 EIAPKLLSFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTA 331

  Fly   361 GTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDA 425
            .|:|||.|||||||||||.|||||||.||.:.|..|..::::.|:|...|:|....|......|:
  Fly   332 FTVAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDS 396

  Fly   426 KLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDD 490
            ..:...|.:.|::|.|:...|....||||...||||..|||.|.|...:.::|.:..|.|....|
  Fly   397 NATVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQAD 461

  Fly   491 FLTEV-------EAVVTDLDIKKLMLTWTEQMGYPVLN-VSKVADGSFKVTQQRFLSNPASYEEA 547
            ....:       :.:.:|.::.:.|.:||.|.|||::. :.....|...:.|.||... ...|:|
  Fly   462 LWNSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQE-HGIEKA 525

  Fly   548 PSDSAYGYKWSVPITWFAD---DGSENS--FIYDYDVDSVGIAVPSEV---QWIKLNVNQTGYYR 604
            .|      .|.||:.:...   |.::.:  |..:..:::..:.:|..:   :|:.||......:|
  Fly   526 SS------CWWVPLRFVRQNLPDFNQTTPQFWLECPLNTKVLKLPDHLSTDEWVILNPQVATIFR 584

  Fly   605 VNYEESLWALLIQQLTTSPARFEI--ADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVP 667
            |||:|..|.|:|:.|...|....|  .::..||:|..|||......|....|:..||.:|:||:|
  Fly   585 VNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLP 649

  Fly   668 WYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYE---EVGWTVDADNHLKN-RLRVSILTAA 728
            |..|...|..|...|..:|.. .:..|.:.|:..:|.   ::....:|...:|: .......:.|
  Fly   650 WQRAIGILNRLGALLNVAEAN-KFKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPFAHFAYSQA 713

  Fly   729 CALGVPDCLQQA-----SERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAET 788
            |...|.||..||     :.|....||.|:     |.:::. |..:......:.:.::|.||...|
  Fly   714 CRYHVADCTDQAKILAITHRTEGQLELPS-----DFQKVA-YCSLLDEGGDAEFLEVFGLFQNST 772

  Fly   789 DASEKLKLMYGLSGVRNSQYLFDFLAQA-SSDESIVRSQDYFTCVQ--------------YIA-- 836
            :.|::..|...|..|||......||... .|||.:: ...|...|:              ||.
  Fly   773 NGSQRRILASALGCVRNFGNFEQFLNYTLESDEKLL-GDCYMLAVKSALNREPLVSPTANYIISH 836

  Fly   837 ANPVGEPVVWEFYREQWPQLTTRFGLNNRN---FGRLIAQITANFASSVKLEEVQHF 890
            |..:||    :|.:::...|......|.|:   ..||.||          ||:::.|
  Fly   837 AKKLGE----KFKKKELTGLLLSLAQNLRSTEEIDRLKAQ----------LEDLKEF 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	140/415 (34%)
		M1_APN_2	75..518	CDD:189008	157/478 (33%)
		ERAP1_C	593..910	CDD:288671	84/329 (26%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	140/415 (34%)
		M1_APN_2	37..496	CDD:189008	157/478 (33%)
		ERAP1_C	573..890	CDD:288671	84/329 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462035
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850