DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8774 and Trhde

DIOPT Version :10

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_001102461.1 Gene:Trhde / 366894 RGDID:728895 Length:1066 Species:Rattus norvegicus


Alignment Length:930 Identity:299/930 - (32%)
Similarity:476/930 - (51%) Gaps:90/930 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSY 112
            |:|          :..|..||..:|.|.||.|.....:|...|:|:..:.|....||..::||:.
  Rat   173 EQW----------QPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACQNATRYVVLHAS 227

  Fly   113 LLDITSVYVLNRE------VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYS 171
            .:.:..|.|....      |..|.|..:.|.|::.|...|.......|.||:...::::|:|.:.
  Rat   228 RVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFR 292

  Fly   172 STYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQ-QT----E 231
            |:|:.. |..|.:..|:|.||:||:||||||||..||||.|::.| ..:|.::|||. :|    |
  Rat   293 SSYVIH-GERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKH-QATYLSLSNMPVETSVFEE 355

  Fly   232 SNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINK--VEFA 294
            ..::.|:    |..:..||||.:...:.:|..:.||.|:..:     ::.||....|.:  .::|
  Rat   356 DGWVTDH----FSQTPLMSTYYLAWAICNFTYRETTTKSGVV-----VRLYARPDAIRRGSGDYA 411

  Fly   295 LEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSI 359
            |...:.:.|:|..|:||||.|.|||:.|:|.....|||:|||..:.|..:|.|||.||.:....:
  Rat   412 LHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDV 476

  Fly   360 AGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQ-FQIVALQPVLLY 423
            ...:.|||.|||||:|||..||.|:||.||||.|.::.|.:.::|.|.|.:| |....|..|:|.
  Rat   477 TMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLL 541

  Fly   424 DAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVT 488
            |...||||:.|:|....:|..:||.|:|:||.::||||...:|...|:..:.:||..|::.|...
  Rat   542 DGLASSHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAAR 606

  Fly   489 DD-FLTEVEAVVTD---LDIKKLMLTWTEQMGYPVLNV--SKVADGSFKVTQQRFLSNPASYEEA 547
            :| :.|..||:..:   ::|:::|..||.||||||:.:  :..|:....:|||.|:.:..:..:|
  Rat   607 NDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIYDIGAKTKA 671

  Fly   548 PSDSAYGYKWSVPIT---------------WFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNV 597
            .......|.|.:|:|               |.::....:...| .|..|          ||..|:
  Rat   672 LQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY-LDKGS----------WILGNI 725

  Fly   598 NQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQE 662
            |||||:||||:...|.|||.||..:.....:::|..|::|||:||.|..|...|||::..||::|
  Rat   726 NQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEE 790

  Fly   663 RDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGW-------TVDADNHLKNRL 720
            :||:||:.||..|..|.:.|...|.|..:..|....:|..|.::||       :|...::....|
  Rat   791 KDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEEL 855

  Fly   721 RVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFV 785
            |..::..||:.|...|.||||...|.::.:...|...::|:|||..|: ....:..|:.::..|.
  Rat   856 RREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGV-SLLDEDVWEFIWMKFH 919

  Fly   786 AETDASEKLKLMYGL--SGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEF 848
            :.|..|||..|:..|  |..||   |...|...|.:..:|..||....:.::|.||.|..:.|:|
  Rat   920 STTAVSEKKILLEALTCSDDRN---LLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKF 981

  Fly   849 YREQWPQLTTRFG----LNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVE 909
            :|::|..|.||:|    :|:    :||:.:|....:..:|:|:::|...|  .|..:.|...|||
  Rat   982 FRDKWKILNTRYGEALFMNS----KLISGVTEFLNTEGELKELKNFMKSY--DGVASASFSRAVE 1040

  Fly   910 TIKYNIEWLSRNEADITDWL 929
            |::.|:.|....:.::..||
  Rat  1041 TVEANVRWKRLYQDELFQWL 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 M1_APN-Q_like 75..513 CDD:341064 157/455 (35%)
ERAP1_C 592..912 CDD:463368 110/332 (33%)
TrhdeNP_001102461.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..177 2/13 (15%)
M1_APN-Q_like 190..635 CDD:341064 157/455 (35%)
ERAP1_C 720..1044 CDD:463368 110/333 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.