DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and VB0395L.1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001024932.1	Gene:	VB0395L.1 / 3564909	WormBaseID:	WBGene00044150	Length:	340	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	77/384 - (20%)
Similarity:	131/384 - (34%)	Gaps:	115/384 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQVVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTDYRLPTNL 72
            |:.:|:|.|::.....:.|.|                 ||.....::........:|   :|...
Worm    14 LRFLLTWLVLSAIACIIYVFV-----------------VFGSLLNKTVLPSNNVPST---IPYIT 58

  Fly    73 VPTHYELYWH----PDLETGNFTGQQRISIKVVEATNQIILH-SYLLDITSVYVLNREVEKFELE 132
            ||:.|.::..    |:.....:||..::.....:.|.|:..| |..:.|.|:          .||
Worm    59 VPSEYNVFLQFNSTPEAVVREYTGSLQMDFVARDITQQLFFHRSDKVKINSI----------SLE 113

  Fly   133 EERQFLIITLT-------------------EELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEA 178
            :...    |:|                   ..|....|..|.|.|.|::.            :|.
Worm   114 DANG----TMTAPTAGAYDKSTGVQAYIPLANLTSQESYVLRIDFQGELD------------SET 162

  Fly   179 GATRTI------STTKFEPTYA---------RQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQ 228
            |:.|.:      .|.::...:.         |...||.|.|...|.|...:.| |..|..:||..
Worm   163 GSPRNLQYSLPNGTIRYSIVFGNSVTSSSGLRYLMPCLDSPDFPAVFNFNIRH-SPRYRVISNFA 226

  Fly   229 -QTESNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVE 292
             |.:.:.|  ||..:|..|..:.:..|.:.:.|......||:.||:             .|||.
Worm   227 GQIQQSIL--YTATLFAGSFQLDSSQVVLALIDTELAPVTVQQNGL-------------TINKY- 275

  Fly   293 FALEFGQAV-----TEYYIQYYKV-PYPLTKLDMAAIPDFASGAMEHWGLVTYRETALL 345
                :.|::     |:..||:... ...:.|:|:.|:||..  |.:..|:..|.|..:|
Worm   276 ----YRQSIVDNISTDRIIQFMATRSQQIGKIDVLALPDLT--ATQQPGITFYNENDVL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	68/325 (21%)
		M1_APN_2	75..518	CDD:189008	65/317 (21%)
		ERAP1_C	593..910	CDD:288671
VB0395L.1	NP_001024932.1	GluZincin	63..>224	CDD:301352	34/187 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900