DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and anpepb

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001082794.1	Gene:	anpepb / 322533	ZFINID:	ZDB-GENE-030131-1253	Length:	965	Species:	Danio rerio

Alignment Length:	975	Identity:	315/975 - (32%)
Similarity:	497/975 - (50%)	Gaps:	74/975 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRM-----KREDTTDYRLP 69
            :|:....||...|..||..|:.....::.:.|.........:..:.|.:     ..|....:|||
Zfish    16 IVIGAGAVATIIALSVVYSQEKSKNNEIENQQTTTTKGPTTNVPATTNIPTTVPSNEPWDQWRLP 80

  Fly    70 TNLVPTHYELYWHPDLETGN-----FTGQQRISIKVVEATNQIILHSYLL---DITSVYVLN--- 123
            ..|.|..|::...|.|:...     |||...:..:.||.|:.|::||..|   |.|::..|.
Zfish    81 QTLSPETYKVTLWPRLQKNAEGLYIFTGDSSVVFRCVENTDLILIHSNKLTIKDSTTLKALGGNP 145

  Fly   124 -REVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTT 187
             ..:...::..:.|::.|.|..||....|..|...|.|::.|.|.|.|.|.|.:|.|..:.::||
Zfish   146 APNIVSTKMYPKTQYMAIWLDRELTAGESYELYTEFVGELSDDLGGFYRSEYYDENGVLKVVATT 210

  Fly   188 KFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSN---MQQTESNYLG-DYTEAIFETSVS 248
            :.:.|.||:||||||||||||.|.|.::|..|:. |:||   :::......| ..|:..|..:..
Zfish   211 QMQATDARKAFPCFDEPAMKAVFNIVLLHDPGTV-ALSNGVVIEEIPVTVDGISLTKTTFAPTEK 274

  Fly   249 MSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQI--NKVEFALEFGQAVTEYYIQYYKV 311
            |||||:..|||:|......:      :|..::.:|....|  |:.|:||.....:..::.:||..
Zfish   275 MSTYLLAFIVSEFTYIEQKL------DDLQIRIFARKEAIDANQGEYALSVTGKILRFFEEYYNS 333

  Fly   312 PYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLV 376
            .|||.|.|..|:|||.:||||:|||:||||||||||...||..||:.:...:|||:|||||||||
Zfish   334 SYPLPKSDQIALPDFNAGAMENWGLITYRETALLYDEEMSSNGNKERVVTVIAHELAHQWFGNLV 398

  Fly   377 TMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQK---VES 438
            |::||||||||||||.|::|.|.:...|.|.:.:...:..:..|...||..||||:..|   |:.
Zfish   399 TIRWWNDLWLNEGFASYVEYLGADEAEPLWNIKDLIVLNDVHRVFAIDALASSHPLSSKEEDVQR 463

  Fly   439 PDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVV---- 499
            |::|:.:||||||.||.||:|||...:..:.|.:.:..||...:|||||..|....::..|
Zfish   464 PEQISEVFDTISYSKGASVLRMLSNFLSEDVFTQGLRTYLEHFKFNNTVYTDLWDHLQMAVDETG 528

  Fly   500 TDL--DIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPIT 562
            |:|  .:|.:|..|..|||:||:.::.|..   :::|:.||.:|   |..|..|.:.|:|.||||
Zfish   529 TELPRSVKDIMDRWVLQMGFPVVTINTVTG---QISQEHFLLDP---ETKPEPSEFNYEWFVPIT 587

  Fly   563 WFADDG--------SENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQL 619
            |..::.        .:|:...|...::        .:|:..|:|..|||||||:|..|..|:..|
Zfish   588 WTKNEAIKPQYWLLQKNTQFDDMKTNA--------NEWVLANINTVGYYRVNYDEQNWERLLNAL 644

  Fly   620 TTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMF 684
            .||.....:.:|..|::|||.||.|..:...:.|..|.:|..|.:::||..|.|.|...:  |||
Zfish   645 QTSRESIPVINRAQLIDDAFNLAKAGIIKTTLALRTTEFLDVETEYMPWQSALNNLDYFY--LMF 707

  Fly   685 --SEGYVSYLTYARSLIAGVYEE----VGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASER 743
              ||.|.....|.|..:..::|.    ..|....|||.:...:|:.|..||::|:.:|....:..
Zfish   708 DRSEVYGHMQAYIRKQVTPLFEYFTELTDWQGVPDNHTEQYNQVNALRVACSIGLKNCTDLVTSW 772

  Fly   744 FSTFLENPTTRP-SPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQ 807
            |..::.|....| ..:||..||...:....:: .|:..:::|...:.||||.||...:: .....
Zfish   773 FGEWMNNEDVNPIHANLRSTVYCSAIAAGGAE-EWEFAWKMFEKTSVASEKDKLRAAMA-CATQP 835

  Fly   808 YLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIA 872
            :|.:...:.:.|.:.:|.||..:.:..||:|..|:.:.|:|.|..|..:..::|..:.:|..||.
Zfish   836 WLLNRYLEYTLDANKIRKQDATSTIVSIASNVGGQSLAWDFVRANWEYIFNQYGGGSFSFSNLIN 900

  Fly   873 QITANFASSVKLEEVQHFFSKYPESGAGANSRL--EAVETIKYNIEWLSRNEADITDWLSGTASP 935
            .:|..|::..:|:::..|.......|.|:.|..  :::|..|.||:|:.:|:||:..|....:.|
Zfish   901 GVTKRFSTEFELKQLMQFKEDNEHIGFGSGSLAIQQSIERTKANIKWVEQNKADVLQWFKDQSKP 965

Fly 936 935
Zfish 966 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	160/407 (39%)
		M1_APN_2	75..518	CDD:189008	180/469 (38%)
		ERAP1_C	593..910	CDD:288671	90/325 (28%)
anpepb	NP_001082794.1	Peptidase_M1	78..479	CDD:279741	160/407 (39%)
		M1_APN_2	88..549	CDD:189008	180/467 (39%)
		ERAP1_C	618..940	CDD:288671	90/325 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920