Protein Alignment CG8774 and Lta4h

DIOPT Version :9

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_001025202.1
• Gene: Lta4h / 299732
• RGDID: 1311333
• Length: 611
• Species: Rattus norvegicus
• Alignment Length: 831
• Identity: 164/831 - (19%)
• Similarity: 278/831 - (33%)
• Gaps: 280/831 - (33%)

  Fly    62 DTTDYRLPTNLVPT-HYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSV----YV 121
            ||.....|.::..| |..|....|......||...::::..|..    |.|..||...:    .|
  Rat     6 DTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQSQEDN----LRSLTLDTKDLTIEKVV 66

  Fly   122 LNREVEKFELEEERQF----LIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATR 182
            :|.:..|:.|.|.:.:    :.|:|...|:.:..:.:.|.|  :...|...|...|....:|...
  Rat    67 INGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVVIEISF--ETSPKSSALQWLTPEQTSGKQH 129

  Fly   183 TISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAI--FET 245
            ....::.:..:.|...||.|.|::|.|:...|..|......:|.::..|:....|.:..|  |..
  Rat   130 PYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQ 194

  Fly   246 SVSMSTYLVCIIVSDFASQSTTVKANGIG---------EDFSMQAYATSHQINKVEFALEFGQAV 301
            .|.:..||:.::|....|:.       ||         |.....||..|...:.::.|.:.|.
  Rat   195 RVPIPCYLIALVVGALESRQ-------IGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGG-- 250

  Fly   302 TEYYIQYYKVPYPLTKLDMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAH 365
                      ||...:.|:..: |.|..|.||:..|.....|.|         |..:|::..:||
  Rat   251 ----------PYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLL---------AGDKSLSNVIAH 296

  Fly   366 EIAHQWFGNLVTMKWWNDLWLNEGFARYMQ-----------YKGVNAVHPDWGMLEQFQIVALQP 419
            ||:|.|.|||||.|.|:..|||||...|::           ::..:|: ..||.|:       ..
  Rat   297 EISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHAL-GGWGELQ-------NT 353

  Fly   420 VLLYDAKLSSHPIVQ-----KVESPDEITAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYL 478
            :..:.   .|||..:     |...||   ..:.:|.||||.:::..||.|:|. |.|...:..|:
  Rat   354 IKTFG---ESHPFTKLVVDLKDVDPD---VAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYV 412

  Fly   479 VKHQFNNTVTDDFLTEVEAVVTD-LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPA 542
            .|..:.:..|||:.:.:.|...| :|:               ||
  Rat   413 EKFSYQSVTTDDWKSFLYAHFKDKVDL---------------LN--------------------- 441

  Fly   543 SYEEAPSDSAYGYKWSVPITWFADDGSENSFIY---------DYDVDSVGIAVPSEVQWIKLNVN 598
                             .:.|       |:::|         :|||......:....:|:...
  Rat   442 -----------------QVDW-------NAWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAK-- 480

  Fly   599 QTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQER 663
                     ||.|.:..|:.|....:        |.||:..|     |:..|.||.:
  Rat   481 ---------EEDLNSFSIEDLKDLSS--------HQLNEFLA-----QVLQKAPLPL-------- 515

  Fly   664 DFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAA 728
                                   |::..:           :|| :..:|.|:.:.|.|...|
  Rat   516 -----------------------GHIKRM-----------QEV-YNFNAINNSEIRFRWLRL--- 542

  Fly   729 CALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEK 793
                   |:                                    ||.|::...|         .
  Rat   543 -------CI------------------------------------QSKWEEAIPL---------A 555

  Fly   794 LKLMYGLSGVRNSQYLFDFLA--QASSDESIVRSQDYFTCVQYIAANPVGE 842
            ||:......::.::.||..||  ..|.|:::...|::..|:..:.|..||:
  Rat   556 LKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKACMHPVTAMLVGK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	98/423 (23%)
		M1_APN_2	75..518	CDD:189008	113/481 (23%)
		ERAP1_C	593..910	CDD:288671	39/252 (15%)
Lta4h	NP_001025202.1	leuko_A4_hydro	6..608	CDD:274120	164/831 (20%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810