DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8774 and TRHDE

DIOPT Version :10

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_037513.2 Gene:TRHDE / 29953 HGNCID:30748 Length:1069 Species:Homo sapiens


Alignment Length:940 Identity:301/940 - (32%)
Similarity:478/940 - (50%) Gaps:110/940 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSY 112
            |.|          |..|..||..:|.|.||.|.....:|...|:|:..:.|....||..::||:.
Human   176 EPW----------EPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHAS 230

  Fly   113 LLDITSVYVLNREVEKFELEEERQF----------------LIITLTEELAVDASITLGIIFGGQ 161
            .:          .|||.:|.|:|.|                |::.|...|....:..|.||:...
Human   231 RV----------AVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL 285

  Fly   162 MKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSN 226
            ::::|:|.:.|:|:.. |..|.:..|:|.||:||:||||||||..||||.|::.| ..:|.::||
Human   286 IENELLGFFRSSYVLH-GERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKH-QATYLSLSN 348

  Fly   227 MQ-QT----ESNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSH 286
            |. :|    |..::.|:    |..:..||||.:...:.:|..:.||.|:..:     ::.||...
Human   349 MPVETSVFEEDGWVTDH----FSQTPLMSTYYLAWAICNFTYRETTTKSGVV-----VRLYARPD 404

  Fly   287 QINK--VEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPS 349
            .|.:  .::||...:.:.|:|..|:||||.|.|||:.|:|.....|||:|||..:.|..:|.|||
Human   405 AIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPS 469

  Fly   350 YSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQ-FQ 413
            .||.:....:...:.|||.|||||:|||..||.|:||.||||.|.::.|.:.::|.|.|.:| |.
Human   470 VSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFL 534

  Fly   414 IVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYL 478
            ...|..|:|.|...||||:.|:|....:|..:||.|:|:||.::||||...:|...|:..:.:||
Human   535 TDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYL 599

  Fly   479 VKHQFNNTVTDD-FLTEVEAVVTD---LDIKKLMLTWTEQMGYPVLNV--SKVADGSFKVTQQRF 537
            ..|::.|...:| :.|..||:..:   ::|:::|..||.||||||:.:  :..|:....:|||.|
Human   600 TIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHF 664

  Fly   538 LSNPASYEEAPSDSAYGYKWSVPIT---------------WFADDGSENSFIYDYDVDSVGIAVP 587
            :.:.::..:|.......|.|.:|:|               |.::....:...| .|..|      
Human   665 IYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY-LDKGS------ 722

  Fly   588 SEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIP 652
                |:..|:|||||:||||:...|.|||.||..:.....:::|..|::|||:||.|..|...||
Human   723 ----WLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIP 783

  Fly   653 LDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADN--- 714
            |::..||::|:||:||:.||..|..|.:.|...|.|..:..|....:|..|.::||..:..|   
Human   784 LEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSL 848

  Fly   715 ----HLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQS 775
                :....||..::..||:.|...|.||||...|.::.:...|...::|:|||..|: ....:.
Human   849 VQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGV-SLLDED 912

  Fly   776 SWDQLFQLFVAETDASEKLKLMYGL--SGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAAN 838
            .|:.::..|.:.|..|||..|:..|  |..||   |.:.|...|.:..:|..||....:.::|.|
Human   913 VWEFIWMKFHSTTAVSEKKILLEALTCSDDRN---LLNRLLNLSLNSEVVLDQDAIDVIIHVARN 974

  Fly   839 PVGEPVVWEFYREQWPQLTTRFG----LNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGA 899
            |.|..:.|:|:|::|..|.||:|    :|:    :||:.:|....:..:|:|:::|...|  .|.
Human   975 PHGRDLAWKFFRDKWKILNTRYGEALFMNS----KLISGVTEFLNTEGELKELKNFMKNY--DGV 1033

  Fly   900 GANSRLEAVETIKYNIEWLSRNEADITDWL 929
            .|.|...||||::.|:.|....:.::..||
Human  1034 AAASFSRAVETVEANVRWKMLYQDELFQWL 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 M1_APN-Q_like 75..513 CDD:341064 158/465 (34%)
ERAP1_C 592..912 CDD:463368 110/332 (33%)
TRHDENP_037513.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..179 2/12 (17%)
M1_APN-Q_like 193..638 CDD:341064 158/465 (34%)
ERAP1_C 723..1047 CDD:463368 110/333 (33%)
Blue background indicates that the domain is not in the aligned region.

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