DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and ANPEP

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	994	Identity:	315/994 - (31%)
Similarity:	499/994 - (50%)	Gaps:	115/994 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQVVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTD------- 65
            |.::|..|.|....|..||..|:.....:...|.....     |..:.|......|.|
Human    14 LGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTP-----SASATTNPASATTLDQSKAWNR 73

  Fly    66 YRLPTNLVPTHYELYWHPDLETGN-----FTGQQRISIKVVEATNQIILHSYLLDITSVYVLNR- 124
            ||||..|.|..|.:...|.|...:     |.|...:.....|||:.||:||..|:    |.|::
Human    74 YRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLN----YTLSQG 134

  Fly   125 --------------EVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYL 175
                          :::|.||.|..::|::.|...|..|:...:...|.|::.|.|.|.|.|.|:
Human   135 HRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYM 199

  Fly   176 NEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNM--------QQTES 232
             |....:.::||:.:...||::|||||||||||.|.||::||. ...|:|||        ...:.
Human   200 -EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPK-DLTALSNMLPKGPSTPLPEDP 262

  Fly   233 NYLGDYTEAIFETSVSMSTYLVCIIVSDF------ASQSTTVKANGIGEDFSMQAYATSHQINKV 291
            |:  :.||  |.|:..|||||:..|||:|      ||....::...     ...|.|..|.
Human   263 NW--NVTE--FHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWA-----RPSAIAAGHG---- 314

  Fly   292 EFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANK 356
            ::||.....:..::..:|..||||.|.|...:|||.:||||:||||||||.:||:||..||::||
Human   315 DYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNK 379

  Fly   357 QSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVL 421
            :.:...:|||:||||||||||::||||||||||||.|::|.|.:...|.|.:.:...:..:..|:
Human   380 ERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVM 444

  Fly   422 LYDAKLSSHPI---VQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQF 483
            ..||..||||:   ..::.:|.:|:.:||.|||.||.||:|||.:.:..:.|::.:.:||....:
Human   445 AVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAY 509

  Fly   484 NNTVTDDFLTEVEAVVTDLDI------KKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPA 542
            .||:..:....::..|.:..|      :.:|..||.|||:||:.|. .:.|:  ::|:.||.:|.
Human   510 QNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVD-TSTGT--LSQEHFLLDPD 571

  Fly   543 SYEEAPSDSAYGYKWSVPIT-----------WFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLN 596
            |....||:  :.|.|.||||           |..|..::|      |:.|.     |..:|:.||
Human   572 SNVTRPSE--FNYVWIVPITSIRDGRQQQDYWLIDVRAQN------DLFST-----SGNEWVLLN 623

  Fly   597 VNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQ 661
            :|.||||||||:|..|..:..||....:...:.:|..::||||.||.|:::...:.|:.|.:|.:
Human   624 LNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIE 688

  Fly   662 ERDFVPWYVASNKLRSLHRSLMF--SEGYVSYLTYARSLIAGVY-----EEVGWTVDADNHLKNR 719
            ||.::||..|.:.|.  :..|||  ||.|.....|.:..:..::     ....|....:|.:...
Human   689 ERQYMPWEAALSSLS--YFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQY 751

  Fly   720 LRVSILTAACALGVPDCLQQASERFSTFLENPTTRP-SPDLREIVYYYGMQQSTSQSSWDQLFQL 783
            ..|:.::.||:.|||:|.:..|..|..::|||...| .|:||..||...:.|. .:..||..::.
Human   752 SEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQG-GEEEWDFAWEQ 815

  Fly   784 FVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEF 848
            |...|..:|..||...|:..:....|..:|:...:.: ::|.||..:.:..|..|.:|:.:||:|
Human   816 FRNATLVNEADKLRAALACSKELWILNRYLSYTLNPD-LIRKQDATSTIISITNNVIGQGLVWDF 879

  Fly   849 YREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRL--EAVETI 911
            .:..|.:|...:|..:.:|..||..:|..|::..:|::::.|.....|:|.|:.:|.  :|:|..
Human   880 VQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKT 944

  Fly   912 KYNIEWLSRNEADITDWLS 930
            |.||:|:..|:..:..|.:
Human   945 KANIKWVKENKEVVLQWFT 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	156/423 (37%)
		M1_APN_2	75..518	CDD:189008	171/485 (35%)
		ERAP1_C	593..910	CDD:288671	94/326 (29%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..62		3/26 (12%)
		Metalloprotease	69..967		302/934 (32%)
		M1_APN-Q_like	84..545	CDD:341064	167/479 (35%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269\|PubMed:1350662, ECO:0000269\|PubMed:8887485	288..295		0/6 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:22932899	352..356		3/3 (100%)
		ERAP1_C	619..946	CDD:403137	96/330 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850