Protein Alignment CG8774 and ape2

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_595998.1
• Gene: ape2 / 2540648
• PomBaseID: SPBC1921.05
• Length: 882
• Species: Schizosaccharomyces pombe
• Alignment Length: 898
• Identity: 270/898 - (30%)
• Similarity: 444/898 - (49%)
• Gaps: 51/898 - (5%)

  Fly    55 RTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSV 119
            ::..|.:|.....||.|:.|.||:|..:|||||..:.|:..:::.|:|.:|.|.||...|.|.:.
pombe     7 KSTSKEDDKNRNLLPKNVKPIHYDLSLYPDLETFTYGGKVVVTLDVLEDSNSITLHGINLRILTA 71

  Fly   120 YVL--NREVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATR 182
            .:.  ::.|...|:....:.:::.....:..::...|.:.|..::...:.|.|.|:|::..|.|:
pombe    72 ALEWGSQTVWASEVSYGDERIVLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDSDGNTK 136

  Fly   183 TISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSV 247
            .::||:.|||.||:||||:||||:||||.|.:. ...:|..:|||...|.........|.|..:.
pombe   137 YLATTQMEPTSARRAFPCWDEPALKATFTIDIT-AKENYTILSNMNAVEETVKDGLKTARFAETC 200

  Fly   248 SMSTYLVCIIVS--DFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYK 310
            .|||||:..||:  ::....|..|.   .....::.|.|.....:.:||.|.|....:::...:.
pombe   201 RMSTYLLAWIVAELEYVEYFTPGKH---CPRLPVRVYTTPGFSEQGKFAAELGAKTLDFFSGVFG 262

  Fly   311 VPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNL 375
            .||||.|.||.|||||.:||||:|||||||..|:|.....::|..:: :|..:.||:||||||||
pombe   263 EPYPLPKCDMVAIPDFEAGAMENWGLVTYRLAAILVSEDSAATVIER-VAEVVQHELAHQWFGNL 326

  Fly   376 VTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPD 440
            |||::|:.||||||||.:|.:...|..:|:|.:.|.:....||..|..||..|||||...:....
pombe   327 VTMQFWDGLWLNEGFATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHPIEVPIMHDY 391

  Fly   441 EITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIK 505
            ||..|||.|||.||..||||:...||.:.|.:.:..|:.||::.||||:|....:.| .:..||.
pombe   392 EINQIFDAISYSKGSCVIRMVSKYVGEDTFIKGIQKYISKHRYGNTVTEDLWAALSA-ESGQDIS 455

  Fly   506 KLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDG-- 568
            ..|..||::.|||||:||:..||...:.|.||||   :.:..|.:....| |:........||
pombe   456 STMHNWTKKTGYPVLSVSETNDGELLIEQHRFLS---TGDVKPEEDTVIY-WAPLKLKTMKDGKA 516

  Fly   569 --SENSFIYDYDVDSVGIAVPSE-VQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIAD 630
              .|.:.:.|   .|..|.|..| ::..|||..|:|.|||||.......|.|.....|....:.|
pombe   517 VVDEKAVLSD---RSKKIKVDKEALESYKLNSEQSGIYRVNYSADHLKKLSQIAVEKPDYLSVED 578

  Fly   631 RGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYA 695
            |..|:.|..:|:.|........||:......|.:||.:.....:|..:..:|.|....:  :...
pombe   579 RAGLIADVASLSRAGYGKVSSTLDLIKTWKDEPNFVVFAEMLARLNGIKSTLRFESSDI--IAAM 641

  Fly   696 RSLIAGV----YEEVGWTVDA-DNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRP 755
            :.|:..|    ...:||...| |:|:..:.:.::...|...|....::.|..:|..:.....:..
pombe   642 KKLVLEVSATKAHSLGWEFKANDDHIIRQFKSTVYNYAGLFGDDKVVKDALSKFDAYASGNKSAI 706

  Fly   756 SPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSD- 819
            :.:||..|:...::...:: |||||.:::....|...:...:.......:.:|:     |.:.|
pombe   707 NDNLRSAVFNIAIRYGGAK-SWDQLLEIYTKTNDPYVRNSCLRAFGVTEDEKYI-----QKTLDL 765

  Fly   820 --ESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSV 882
              :.||:.||.:..:..::.:..|...:|:|....|.:|.:|..:.....|.::..:|:.|..:.
pombe   766 TLDPIVKEQDIYLILVTLSTHKNGVLAMWKFATSNWDKLLSRLPVAGTMRGYVVRFVTSGFTHAS 830

  Fly   883 KLEEVQHFFSKYPESGAGANSRL------EAVETIKYNIEWLSRNEADITDWL 929
            .:::::.||       |..:::|      ::::||..|..::.::..|||.||
pombe   831 AIDKIKEFF-------ADKDTKLYERALQQSLDTISANSSFIDKSLDDITRWL 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	163/441 (37%)
		ERAP1_C	592..912	CDD:463368	68/333 (20%)
ape2	NP_595998.1	M1_APN-Q_like	27..463	CDD:341064	163/441 (37%)
		ERAP1_C	541..858	CDD:463368	67/331 (20%)