DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and Lnpep

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_766415.1	Gene:	Lnpep / 240028	MGIID:	2387123	Length:	1025	Species:	Mus musculus

Alignment Length:	892	Identity:	303/892 - (33%)
Similarity:	470/892 - (52%)	Gaps:	62/892 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLN------RE 125
            ||||.::|..|||..||:|.:..|.|...||::.::.|..|||||...:|:.|..::      ::
Mouse   167 RLPTAIIPLCYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISRVTFMSAVSSQEKQ 231

  Fly   126 VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFE 190
            ||..|.....|..::. .|.|....:.||.|.:...:.:...|.|..||.:::...:..:.|:||
Mouse   232 VEILEYPYHEQIAVVA-PEPLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKYFAATQFE 295

  Fly   191 PTYARQAFPCFDEPAMKATFAITVVHPSGSYH-AVSNMQQ-----TESNYLGDYTEAIFETSVSM 249
            |..||.|||||||||.||||.|.:..  ..:| |:|||.:     .|...:.|.    |..||.|
Mouse   296 PLAARSAFPCFDEPAFKATFIIKITR--NEHHTALSNMPKKSSVPAEEGLIQDE----FSESVKM 354

  Fly   250 STYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYP 314
            |||||..||.:..:.|..|  ||.    .:..||...:|.:|..||:....:.|:|..|:::.||
Mouse   355 STYLVAFIVGEMRNLSQDV--NGT----LVSVYAVPEKIGQVHHALDTTIKLLEFYQTYFEIQYP 413

  Fly   315 LTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMK 379
            |.|||:.|||||.:||||:|||:|:||..||||.:.||.|:::.:...:|||:|||||||||||:
Mouse   414 LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQ 478

  Fly   380 WWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITA 444
            ||||||||||||.:|:|..|..:..:....|.| :.|....:..|:..|||||...|:|.::|..
Mouse   479 WWNDLWLNEGFATFMEYFSVEKIFKELNSYEDF-LDARFKTMRKDSLNSSHPISSSVQSSEQIEE 542

  Fly   445 IFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTD--LDIKKL 507
            :||::||.||.|::.||::.:..:.|..||..||..|.:....:|| |.:....|||  ||:||:
Mouse   543 MFDSLSYFKGASLLLMLKSYLSEDVFRHAVILYLHNHSYAAIQSDD-LWDSFNEVTDKTLDVKKM 606

  Fly   508 MLTWTEQMGYPVLNVSKVADGSFKVTQQRFL--SNPASYEEAPSDSAYGYKWSVPITWFAD--DG 568
            |.|||.|.|:|::.|.:... ...:.|:||.  ..|   |..|||::  :.|.:||::..|  :.
Mouse   607 MKTWTLQKGFPLVTVQRKGT-ELLLQQERFFLRMQP---ESQPSDTS--HLWHIPISYVTDGRNY 665

  Fly   569 SENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGH 633
            ||...:...|..|..|.:..:|||:|:|.|.||||.|:|....|..||.||..:|......||.:
Mouse   666 SEYRSVSLLDKKSDVINLTEQVQWVKVNSNMTGYYIVHYAHDDWTALINQLKRNPYVLSDKDRAN 730

  Fly   634 LLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVA---SNKLRSLHRSLMFSEGYVSYLTYA 695
            |:|:.|.||...::..::..|:..||..|....|...|   :|.:.:|...|       .::..:
Mouse   731 LINNIFELAGLGKVPLRMAFDLIDYLKNETHTAPITEALFQTNLIYNLLEKL-------GHMDLS 788

  Fly   696 RSLIAGVY-------EEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTT 753
            ..|:|.|:       ::..|| |........||.::|..|||..:.:|...|:..|.:::.:..|
Mouse   789 SRLVARVHKLLQNQIQQQTWT-DEGTPSMRELRSALLEFACAHSLENCTTMATNLFDSWMASNGT 852

  Fly   754 RPSP-DLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQAS 817
            :..| |:...|:..|   :.::..|..||.::.:....:||.|::..|:...:...|: :|.::|
Mouse   853 QSLPTDVMVTVFKVG---ARTEKGWLFLFSMYSSMGSEAEKNKILEALASSEDVHKLY-WLMKSS 913

  Fly   818 SDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSV 882
            .|..|:|:|.....::.:..:..|..:.|:|.:|.|.:|..:|.|.:.....::|..|..|::..
Mouse   914 LDGDIIRTQKLSLIIRTVGRHFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKT 978

  Fly   883 KLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            .|.|||.||....|:........||:|.|:.||:|:.||...::.||
Mouse   979 HLSEVQAFFENQSEATLKLRCVQEALEVIQLNIQWMVRNLKTLSQWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	160/398 (40%)
		M1_APN_2	75..518	CDD:189008	182/456 (40%)
		ERAP1_C	593..910	CDD:288671	85/327 (26%)
Lnpep	NP_766415.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	160/398 (40%)
		M1_APN_2	177..617	CDD:189008	182/454 (40%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	85/326 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820