DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8774 and Trhde

DIOPT Version :10

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_666353.2 Gene:Trhde / 237553 MGIID:2384311 Length:1066 Species:Mus musculus


Alignment Length:930 Identity:299/930 - (32%)
Similarity:475/930 - (51%) Gaps:90/930 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSY 112
            |:|          :..|..||..:|.|.||.|.....:|...|:|:..:.|....||..::||:.
Mouse   173 EQW----------QPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHAS 227

  Fly   113 LLDITSVYVLNRE------VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYS 171
            .:.:..|.|....      |..|.|..:.|.|::.|...|.......|.||:...::::|:|.:.
Mouse   228 RVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFR 292

  Fly   172 STYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQ-QT----E 231
            |:|:.. |..|.:..|:|.||:||:||||||||..||||.|::.| ..:|.::|||. :|    |
Mouse   293 SSYVIH-GERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKH-QATYLSLSNMPVETSVFEE 355

  Fly   232 SNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINK--VEFA 294
            ..::.|:    |..:..||||.:...:.:|..:.||.|:..:     ::.||....|.:  .::|
Mouse   356 DGWVTDH----FSQTPLMSTYYLAWAICNFTYRETTTKSGVV-----VRLYARPDAIRRGSGDYA 411

  Fly   295 LEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSI 359
            |...:.:.|:|..|:||||.|.|||:.|:|.....|||:|||..:.|..:|.|||.||.:....:
Mouse   412 LHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDV 476

  Fly   360 AGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQ-FQIVALQPVLLY 423
            ...:.|||.|||||:|||..||.|:||.||||.|.::.|.:.::|.|.|.:| |....|..|:|.
Mouse   477 TMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLL 541

  Fly   424 DAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVT 488
            |...||||:.|:|....:|..:||.|:|:||.::||||...:|...|:..:.:||..|::.|...
Mouse   542 DGLASSHPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAAR 606

  Fly   489 DD-FLTEVEAVVTD---LDIKKLMLTWTEQMGYPVLNV--SKVADGSFKVTQQRFLSNPASYEEA 547
            :| :.|..||:..:   ::|:::|..||.||||||:.:  :..|:....:|||.|:.:..:..:|
Mouse   607 NDLWNTLSEALRRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRILITQQHFIYDIGAKTKA 671

  Fly   548 PSDSAYGYKWSVPIT---------------WFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNV 597
            .......|.|.:|:|               |.::....:...| .|..|          ||..|:
Mouse   672 LQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRIAY-LDRGS----------WILGNI 725

  Fly   598 NQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQE 662
            |||||:||||:...|.|||.||..:.....:::|..|::|||:||.|..|...|||::..||::|
Mouse   726 NQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEE 790

  Fly   663 RDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADN-------HLKNRL 720
            :||:||:.||..|..|.:.|...|.|..:..|....:|..|.::||..:..|       :....|
Mouse   791 KDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQHEEL 855

  Fly   721 RVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFV 785
            |..::..||:.|...|.||||...|.::.:...|...::|:|||..|: ....:..|:.::..|.
Mouse   856 RREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGV-SLLDEDVWEFIWMKFH 919

  Fly   786 AETDASEKLKLMYGL--SGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEF 848
            :.|..|||..|:..|  |..||   |...|...|.:..:|..||....:.::|.||.|..:.|:|
Mouse   920 STTAVSEKKILLEALTCSDDRN---LLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKF 981

  Fly   849 YREQWPQLTTRFG----LNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVE 909
            :|::|..|.||:|    :|:    :||:.:|....:..:|:|:::|...|  .|..:.|...|||
Mouse   982 FRDKWKILNTRYGEALFMNS----KLISGVTEFLNTEGELKELKNFMKSY--DGVASASFSRAVE 1040

  Fly   910 TIKYNIEWLSRNEADITDWL 929
            |::.|:.|....:.::..||
Mouse  1041 TVEANVRWKRFYQDELFQWL 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 M1_APN-Q_like 75..513 CDD:341064 157/455 (35%)
ERAP1_C 592..912 CDD:463368 110/332 (33%)
TrhdeNP_666353.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..176 2/12 (17%)
M1_APN-Q_like 190..635 CDD:341064 157/455 (35%)
ERAP1_C 720..1044 CDD:463368 110/333 (33%)
Blue background indicates that the domain is not in the aligned region.

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