DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and LVRN

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	1019	Identity:	296/1019 - (29%)
Similarity:	483/1019 - (47%)	Gaps:	137/1019 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGYWLQ----VVLSWAVVAFATATVVVAVQKAQLER-------DLRDVQDKIDVFEEWSGESRTR 57
            ||:::.    ::|:..|.|...|..|:|......||       .|||::          .||...
Human     7 SGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLE----------AESSPP 61

  Fly    58 MKREDT--------------------------TDYRLPTNLVPTHYEL-YW---HPD-LETGN-- 89
            ::::.|                          ...|||..|||.||:| .|   .|| |..|:
Human    62 LRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLP 126

  Fly    90 FTGQQRISIKVVEATNQIILHSYLLDITSVYVL--------NREVEKFELEE-----ERQFLIIT 141
            |||:..|:::...||::::|||...|.....|.        |..|.:..:::     :.:::::.
Human   127 FTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLE 191

  Fly   142 LTEELAVDASITLGIIFGGQMKDKL-VGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPA 205
            |:|.|...:|..|.:.|.|.:|:.| .||:.:.|.:: |..|.:..::.|||:||..||||||||
Human   192 LSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQ-GERRALLASQLEPTFARYVFPCFDEPA 255

  Fly   206 MKATFAITVVHPSGSYHAVSNM----QQTESNYLGD-YTEAIFETSVSMSTYLVCIIVSDFASQS 265
            :||||.||::| ..||.|:|||    |..:.:..|. :|...|.|:..|.||||..::.|:...:
Human   256 LKATFNITMIH-HPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVN 319

  Fly   266 TTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGA 330
            .|.:    |::..:.|...:......:|||.....:..:....:.:.|.|.|.|:.|:|.|.:.|
Human   320 RTER----GKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHA 380

  Fly   331 MEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQ 395
            ||:|||:.:.|:.||.:|....|..|..|:..::|||.||||||||||.|||::|||||||.|.:
Human   381 MENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFE 445

  Fly   396 YKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVES--PDEITAIFDTISYEKGGSVI 458
            ::.:|..:|.....|.|....|..:|..|..|.:..:..|||:  ..||..:||..:|.||.|:.
Human   446 FEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMA 510

  Fly   459 RMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDF-------LTEVEAVVTDLDIKKLMLTWTEQMG 516
            |||...:....|..|:.:||....::|...||.       :.:...|:....||.:|.:||.|.|
Human   511 RMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSG 575

  Fly   517 YPVLNVSKVADGSFKVTQQRF-LSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVD 580
            :||:.:: |:.|..|  |:.| |.|..:.....|:..    |.|||.|. .:|:....::   :|
Human   576 FPVITLN-VSTGVMK--QEPFYLENIKNRTLLTSNDT----WIVPILWI-KNGTTQPLVW---LD 629

  Fly   581 SVGIAVP------SEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAF 639
            ......|      |:..|:.||:|.||||||||::..|..|.|||...|....:..|..|::|||
Human   630 QSSKVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAF 694

  Fly   640 ALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKL--RSLHRSLMFSEGY---VSYLTYARSLI 699
            :|:..|.:..:..|::|.|||:|.:.:.|:.....|  |.|...:...:.|   ..||....:||
Human   695 SLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLI 759

  Fly   700 AGVYEEV---GWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLRE 761
            ..:|..:   ......|::|.......:...||.||:.||||.:.|.|:.::::|.......:::
Human   760 WNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKD 824

  Fly   762 IVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQ 826
            :|..||:... |...||.|...:...|:..||::|.|.:|..::...|..::..|.|......::
Human   825 VVLCYGIALG-SDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNE 888

  Fly   827 DYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFF 891
            .  ..::.:|::.||..|..:|....|..::.|:|  .::...||..|.....:.:::.|:|.||
Human   889 T--NIIEVVASSEVGRYVAKDFLVNNWQAVSKRYG--TQSLINLIYTIGRTVTTDLQIVELQQFF 949

  Fly   892 SKYPESGAGANSRLEA---VETIK-YNIE----------WLSRN 921
            |...|.    :.|:..   ::||| .|::          ||.||
Human   950 SNMLEE----HQRIRVHANLQTIKNENLKNKKLSARIAAWLRRN 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	144/414 (35%)
		M1_APN_2	75..518	CDD:189008	159/477 (33%)
		ERAP1_C	593..910	CDD:288671	87/327 (27%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		6/52 (12%)
		Peptidase_M1	97..506	CDD:279741	144/414 (35%)
		M1_APN_2	105..577	CDD:189008	159/477 (33%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	84/307 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820