DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and Npepps

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	887	Identity:	297/887 - (33%)
Similarity:	437/887 - (49%)	Gaps:	54/887 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLD-ITSVYVLNREVE--- 127
            |||..:.|.:|.|...|||....|.|:...:.:|.:|||||:::...:| ||:.|....:.|
Mouse    54 RLPAEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHA 118

  Fly   128 ---KFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKF 189
               .::.|:|:..|....|.:....   ||.|.|.|::.||:.|.|.|.|...||..|..:.|:|
Mouse   119 TGFNYQNEDEKVTLSFPSTLQTGTG---TLKIDFVGELNDKMKGFYRSRYTTPAGEVRYAAVTQF 180

  Fly   190 EPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD---YTEAIFETSVSMST 251
            |.|.||:||||:||||:||||.|::|.|.... |:|||...:.....|   ..|..|..:..|||
Mouse   181 EATDARRAFPCWDEPAIKATFDISLVVPKDRV-ALSNMNVIDRKPYPDDENLVEVKFARTPVMST 244

  Fly   252 YLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLT 316
            |||..:|.::....|..| :|:    .::.|....:..:.:||||.......:|..|:.|||||.
Mouse   245 YLVAFVVGEYDFVETRSK-DGV----CVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLP 304

  Fly   317 KLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWW 381
            |:|:.||.|||:||||:||||||||||||.||..|.::::|.:|..:.||:|||||||||||:||
Mouse   305 KIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWW 369

  Fly   382 NDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIF 446
            ..||||||||.:::|..|:...|::.:..||...........||..:||||...|..|.|:..||
Mouse   370 THLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIF 434

  Fly   447 DTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTW 511
            |.|||.||.||||||...:|.:.|::.:..||.|.|..|..|:|....:|: .:...|..:|.||
Mouse   435 DAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLES-ASGKPIAAVMNTW 498

  Fly   512 TEQMGYPVLNV--SKVADGS-FKVTQQRF-LSNPASYEEAPSDSAYGYKWSVPITWFADDGSENS 572
            |:|||:|::.|  .:|.|.. .|::|::| .|.|...|:.|       :|.||||....:....:
Mouse   499 TKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDCP-------QWMVPITISTSEDPNQA 556

  Fly   573 ---FIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALL---IQQLTTSPARFEIADR 631
               .:.|....||.:......||:|||:...|:||..|..::...|   |:.|:..|     .||
Mouse   557 KLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPP-----VDR 616

  Fly   632 GHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYAR 696
            ..|.||.|:||.|..:|....|.:......|.::..|...|..|..|...|..::.|.....:.:
Mouse   617 LGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVK 681

  Fly   697 SLIAGVYEEVGW-TVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLR 760
            .:.:.:.|.:|| ....:.||...||..:|......|....|::|..||...:|..... |.|||
Mouse   682 DVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKEHVEGKQIL-SADLR 745

  Fly   761 EIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRS 825
            ..||...::.... ::.|.:.:|........||.::...|....:.:.:...|..|.|:|  ||.
Mouse   746 SPVYLTVLKHGDG-ATLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQKVLTFALSEE--VRP 807

  Fly   826 QDYFTCVQYIA-ANPVGEPVVWEFYREQWPQLTTRFGLNNRNF--GRLIAQITANFASSVKLEEV 887
            ||..:.:..:| .:..|....|:|.::.|.:|..|:   ...|  .|||......||......||
Mouse   808 QDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELHNRY---QGGFLISRLIKLSVEGFAVDKMAGEV 869

  Fly   888 QHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            :.||..:|...|....: :..|.|..|..||.|:...|..:|
Mouse   870 KAFFESHPAPSAERTIQ-QCCENILLNAAWLKRDADSIHQYL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	161/396 (41%)
		M1_APN_2	75..518	CDD:189008	183/452 (40%)
		ERAP1_C	593..910	CDD:288671	81/323 (25%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	161/396 (41%)
		M1_APN_2	62..505	CDD:189008	183/452 (40%)
		Substrate binding. /evidence=ECO:0000250	317..321		3/3 (100%)
		ERAP1_C	580..891	CDD:288671	81/323 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820