Protein Alignment CG8774 and T12E12.6

DIOPT Version :9

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_500831.2
• Gene: T12E12.6 / 188454
• WormBaseID: WBGene00020465
• Length: 641
• Species: Caenorhabditis elegans
• Alignment Length: 612
• Identity: 154/612 - (25%)
• Similarity: 247/612 - (40%)
• Gaps: 128/612 - (20%)

  Fly    69 PTNLVPTHYELYWH-PDLETGNFTGQQRISIKVVEATNQII-----LHSY-------LLDIT--- 117
            |.|::|..|:|.:. |..|...|||...:...:...::.|.     |||:       ..|:|
 Worm    19 PHNIIPLSYDLLFKLPIHEFNGFTGSMVLHFNLSSLSDNITLDAVDLHSFRNISLIRSADLTEPT 83

  Fly   118 --SVYVLNREVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGA 180
              |:.:|.   ||.||:.|:.                    :|.||.. ..:|.|:....|.:.|
 Worm    84 LKSIKILK---EKVELKFEKS--------------------LFPGQYL-LTIGEYNGRIGNSSEA 124

  Fly   181 -----TRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLG---- 236
                 ...:.||..:|.:||:.|||.|.||:||.|.:::|||:.:.        .:||.:.
 Worm   125 LFERRNPLLYTTHLQPNHARRLFPCIDHPAVKALFRLSIVHPTDTV--------AQSNTIAMDVH 181

  Fly   237 ----DYTEAIFETSVSMSTYLVCIIV--------SDFASQSTTVKANGIGEDFSMQAYATSHQIN 289
                .:...||:.:..:..|||...|        |...|...||:.||......::
 Worm   182 VENRKWQRTIFQATPLLPAYLVAFSVMPDSNLQLSRQTSFGVTVRVNGESRGLVLR--------- 237

  Fly   290 KVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTA 354
                .|:...|..|.......||.||.|:|...:|:: .|.||:||.:|..||       .:::.
 Worm   238 ----VLDCALASFEILAGLIDVPLPLNKIDFILVPEY-DGGMENWGHITVSET-------LATSG 290

  Fly   355 NKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQP 419
            :...:...:||||||.|.||..|:..||.:.|.|....:|..|.|.|:..|...|::||:.....
 Worm   291 DDAHLIYLIAHEIAHHWIGNRATIDSWNWICLQEDLTDWMALKAVKALLTDEIRLQRFQLAQYVE 355

  Fly   420 VLLYDAKLS-SHPIVQKVESPDEIT-AIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLV-KH 481
            :.|.:..|| .|.:..    |.:|. .:.:...|.||..::..||::|| |:|..:|...|| .|
 Worm   356 IQLVEDFLSPGHSLYM----PSKINQELINRHCYLKGVVLLDTLESVVG-EQFMYSVIKSLVGSH 415

  Fly   482 Q-FNNTVTDDFLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYE 545
            . :|.|....:..::. |..:..:.::...|....|||.:.|..  :|.....||  ||.|.
 Worm   416 STYNLTTFTSYFDQIR-VDRNATVGQIYEYWYTTGGYPSILVEN--NGPSSRLQQ--LSRPL--- 472

  Fly   546 EAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEES 610
                       |.:.:|        ::......|.|..|...||...:.:|:|.|.:.||||:..
 Worm   473 -----------WPLKMT--------STLAIPQFVFSESIVFASENAPLLVNLNFTSFMRVNYDSL 518

  Fly   611 LWALLIQQLTTSPARFEIADRGHLLND 637
            .|..:.:.:...|..|....|..|::|
 Worm   519 TWTAIFKYMFEEPELFSAVGRAQLVSD 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	108/425 (25%)
		M1_APN_2	75..518	CDD:189008	122/485 (25%)
		ERAP1_C	593..910	CDD:288671	13/45 (29%)
T12E12.6	NP_500831.2	GluZincin	25..402	CDD:387391	111/434 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920