DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	798	Identity:	224/798 - (28%)
Similarity:	376/798 - (47%)	Gaps:	117/798 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VFEEWSGESRTRMKREDTTDYRLPTNLVPTHYELY---------WHPDLETGNFTGQQRISIKVV 101
            :.:.::.|...|:  .|...||||.::.|:||:::         |..|.....|.|...|.:.:.
Worm    12 IIKPFASELDARI--ADVASYRLPRHVSPSHYDIHIKTYLPGYGWKADENKITFEGNVNILLDIK 74

  Fly   102 EATNQIILHSYLLDITSVYVLNRE----VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQM 162
            |.|::::|||..|:|.|....:.|    :..:.::.|.|||...|...:.|.:|..:.|.|.|::
Worm    75 ETTDKLVLHSSSLNIISATFQSDEQNVSISHWNVQTESQFLTFYLNNTVKVQSSAGIQINFQGKV 139

  Fly   163 KDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNM 227
            :...:||:::....|.|...|...|:||..:||...||||||..|||:.:::.||:|| .|:||.
Worm   140 RTDGLGLFATNSTREDGTVMTNFATQFETIFARNMIPCFDEPEFKATWNVSLEHPTGS-TALSNG 203

  Fly   228 QQTESNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVE 292
            .:.||....|:....::.::.||:|::.:.:.|...:.|.:. ||:    .::.|.....|::|:
Worm   204 IEVESKVNDDWKTTTYKKTLKMSSYILALFIGDIQFKETILN-NGV----RIRVYTDPVNIDRVD 263

  Fly   293 FALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQ 357
            .||...:.|.|.:.:.:.:.||:.|||..::.:|..||||:||||.:...:|:.||        .
Worm   264 HALNISRIVLEGFERQFGIRYPMEKLDFVSVQNFKFGAMENWGLVIHNAYSLIGDP--------M 320

  Fly   358 SIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLL 422
            .:...:.|||||||||||||||:|:.:|||||||.||...|:..:.||: ..:.|.:.......:
Worm   321 DVTEIVIHEIAHQWFGNLVTMKYWDHIWLNEGFASYMTSYGLTFLDPDY-QRDTFYLNCQFNPQI 384

  Fly   423 YDAKLSSHPIVQKVESPDEITAIFDTIS--YEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNN 485
            .|..:|       :.....::::.:..:  |.||.|.:||||.:.|.|.|.||:..||.|:|::|
Worm   385 NDGGVS-------LNFGKNLSSVMNNAATVYMKGCSFVRMLENIFGTEYFNEAIKFYLEKNQYDN 442

  Fly   486 TVTDD----FLTEVEAVVTD---LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPAS 543
            ...:|    |.|..|.:.|:   .||:|....||.|.|:|.:.||. .:|...:||...
Worm   443 VDDNDLYEAFRTSSETLDTNGKPFDIEKFARCWTHQNGFPTIQVSN-DNGIATLTQSHL------ 500

  Fly   544 YEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYE 608
            ||.....:...|||.:|| |:.:.|.....:...:.:|..:.:.::...| :|.|..|||.|.|.
Worm   501 YEPQLMLNECDYKWDIPI-WYQEPGEARVQMAWLNRNSTSLELVADDSVI-INANSIGYYEVLYS 563

  Fly   609 ESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASN 673
            :.::..:.:|:..:.:|:.:......|:|.|..:...         :|.:   ...|:..||
Worm   564 DKMYEKIAEQVAINVSRYSVNSLRRTLHDVFRYSRDG---------LTPF---HNAFIIAYV--- 613

  Fly   674 KLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACALGV----- 733
                    |:|.|..:..           :|.|.:.|||..:..|:..|:........|:
Worm   614 --------LVFGENEILR-----------HESVLYLVDAVYNTNNKSIVNSKDIETVKGLVNQIE 659

  Fly   734 -----PDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFV--AETDAS 791
                 |.|:|  |:.||:..:....: :.:||.|     ||...||::.|    |.|  ||...:
Worm   660 NFELFPKCVQ--SQTFSSCYQKRIPQ-NINLRAI-----MQLKLSQNTMD----LIVAWAENGVN 712

  Fly   792 EKL----KLMYGLSGVRN 805
            |:.    |||.|.|...|
Worm   713 EEAKLGPKLMLGCSTKEN 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	122/401 (30%)
		M1_APN_2	75..518	CDD:189008	147/464 (32%)
		ERAP1_C	593..910	CDD:288671	53/229 (23%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	120/372 (32%)
		M1_APN_2	39..482	CDD:189008	147/464 (32%)
		ERAP1_C	548..>622	CDD:288671	20/97 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164023
Domainoid	1	1.000	101	1.000	Domainoid score	I4343
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850