DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and anp-1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	992	Identity:	296/992 - (29%)
Similarity:	479/992 - (48%)	Gaps:	143/992 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKRED---TTDYRLPTNLVPTHYELY-- 80
            ||.:...:.|:|..|:  |..|:|:      .|:....|.||   .::.||||::.|..|:|.
Worm    44 TAFITWHITKSQYSRN--DPHDEIE------SENVPAAKPEDNISASELRLPTSVSPISYQLTVK 100

  Fly    81 -------WHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYV------LNREVEKFELE 132
                   :..|.....|.||..|.:.:.::..::.|:|..|:.|..::      :|.:...|.|:
Worm   101 TYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDLNYTEEFIKKSSILVNGKSIAFTLD 165

  Fly   133 EER---QFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYA 194
            :::   :.:...|.|.:....|.||.:.||..::..:.|||.:||.|..|.::..:.|:.||.||
Worm   166 DKQSTHEKIFFNLDETVEPTTSATLKVAFGAPLRTDMSGLYQTTYTNSKGESKMAAVTQMEPVYA 230

  Fly   195 RQAFPCFDEPAMKATFAITVVHPSGSYHAVSN--MQQTESNYLGDYTEAIFETSVSMSTYLVCII 257
            |:..|||||||.|||:.:||:||:.:. ||||  ..:.|....| :..:.|:.:..||:||:.|.
Worm   231 RRMVPCFDEPAYKATWTVTVIHPNKTV-AVSNGIEDKVEDGQPG-FIISTFKPTPRMSSYLLAIF 293

  Fly   258 VSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAA 322
            :|:|.....|.| :|:    ..:.::...:.|...:|:|.|....|||.:||.:.:||.|.||.|
Worm   294 ISEFEYNEATTK-SGV----RFRVWSRPEEKNSTMYAVEAGVKCLEYYEKYYNISFPLPKQDMVA 353

  Fly   323 IPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLN 387
            :|||::||||:|||:||||:||||||...|.:.|:.:|..:|||:||||||||||:|||||||||
Worm   354 LPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVAVVIAHELAHQWFGNLVTLKWWNDLWLN 418

  Fly   388 EGFARYMQYKGVNAVHP-DWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISY 451
            ||||..::|.|.:.:.. :..|.|.|.:.||...|..|:..|:||:..|::...|:...||:::|
Worm   419 EGFATLVEYLGTDEISDGNMRMREWFTMDALWSALAADSVASTHPLTFKIDKAMEVLDSFDSVTY 483

  Fly   452 EKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTD---------LDIKKL 507
            :|||:|:.|:...:|.|.|...:.:||.:|||:|....:.||.:...:.|         |:|.:.
Worm   484 DKGGAVLAMVRKTIGEENFNTGINHYLTRHQFDNADAGNLLTALGEKIPDSVMGPKGVKLNISEF 548

  Fly   508 MLTWTEQMGYPVLNVSKVADGSFKVTQQRF-LSNPASYEEAPSDSAYGYKWSVPITWFADDGSEN 571
            |..||:|:|||:||.|::.:....|.|.|| |......||..|:..:|:||.||: |:...||..
Worm   549 MDPWTKQLGYPLLNASRINNTHIIVEQSRFKLLATGKEEEKYSNPVWGFKWDVPV-WYQVVGSSE 612

  Fly   572 SFIYDYDVDSVGIAVPSEVQWIK--------------LNVNQTGYYRVNYEESLWALLIQQLTTS 622
                            .|::|:|              :|....|:||..|...||..:.:.|..:
Worm   613 ----------------LEMKWMKRNEPLIIKSDKNVIINAESNGFYRAGYSSGLWKEISEMLKEN 661

  Fly   623 PARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSL--------- 678
            ..:|....|..|::|:||||.|..|||.|||::..||..|::::||..|..|:|.|
Worm   662 HEQFSPQTRVRLIDDSFALARAGLLSYSIPLNLITYLKNEKEYLPWSGAIAKIRELIDMYGSNPE 726

  Fly   679 -----------------HRSLMF-SEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSIL 725
                             .||:.| |:.|         |....:.|||            ....|:
Worm   727 KDIVNKFMIALAENAPARRSIDFVSKNY---------LDEKKFYEVG------------AAQQII 770

  Fly   726 TAACALGVPDCLQQASERF----------STFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQL 780
            ..:|..|...|.....:.|          :..|...:..|:| .|...|...::...| .:::::
Worm   771 LNSCGFGDSVCQADMVKMFTEEVLAKCDATRILSECSQIPAP-FRAESYCEAVRNGNS-DTFEKV 833

  Fly   781 FQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDE-SIVRSQDYFTCVQYIAANPVGEPV 844
            |..:..|.:..|||.||..|:..::...|...|..|...| |..|.||.......|::|......
Worm   834 FHWYKTERNQVEKLNLMTALTCSKDILTLKKLLLDAMKPEGSSFRLQDCAALFAKISSNDATTDA 898

  Fly   845 VWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVE 909
            :..|..::|..:..|...::..|.|:::.|.....:...|::::.|..|.|::......::|  |
Worm   899 MLNFLIDRWEDMQKRLATDHSGFSRVLSSIVNTLKTRGGLDQLRKFRKKAPKASEFGLDKME--E 961

  Fly   910 TIKYNIEWLSRNEADIT 926
            :.:..:.|...|...:|
Worm   962 SAEVTVTWRETNLKFVT 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	151/407 (37%)
		M1_APN_2	75..518	CDD:189008	170/472 (36%)
		ERAP1_C	593..910	CDD:288671	82/368 (22%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	151/407 (37%)
		M1_APN_2	93..559	CDD:189008	170/472 (36%)
		ERAP1_C	632..964	CDD:288671	82/356 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I4343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		oto19827
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.000