Protein Alignment CG8774 and Y42A5A.1

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_505820.1
• Gene: Y42A5A.1 / 179536
• WormBaseID: WBGene00012776
• Length: 1045
• Species: Caenorhabditis elegans
• Alignment Length: 1028
• Identity: 256/1028 - (24%)
• Similarity: 442/1028 - (42%)
• Gaps: 179/1028 - (17%)

  Fly    10 VVLSWAVVAF-----ATATVVVAVQKAQLERDLRDVQDKIDV-FEEWSGESRTRMKRED------ 62
            |.:|:|::.|     .|::::.:.....|..|:..:..|... |..::..:......||
 Worm    80 VSMSFALIYFFMIVPLTSSILPSQSSPILPSDISTIYQKSSTDFPIFTNSTELITTTEDPLYVHI 144

  Fly    63 -TTDYRL--PTNLVPTHYELY------WHPDLETG--NFTGQQRISIKVVE-ATNQIILHS---- 111
             .|::||  |...:|..||:.      |.|.:..|  ||:.:..:.:.... ..::|:|||
 Worm   145 NNTNHRLQIPQIHIPLLYEVELKLFVPWRPTISFGSDNFSVKGHVRVHFTSGGGSRILLHSDSKQ 209

  Fly   112 YLLDITSVYVLNREVE-KFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLV-GLYSSTY 174
            ::.|......|||.:. |....:..|.|.:.|..::....:.||.:.|...:...|. ||:::.|
 Worm   210 HIGDCVVRDELNRNITVKLVGRQYSQILDLNLETDMIHGMNYTLDVAFKSAINLNLAYGLFAAPY 274

  Fly   175 LNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYT 239
            ..| ..||.:..|:.:.:.||..|||.|.|.|||.|...::||:|: .:::||.:..:...|::|
 Worm   275 TFE-NETRYVVATQLQISEARTVFPCIDVPDMKAQFDTVIIHPTGT-TSIANMMENSTKVDGEWT 337

  Fly   240 EAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEY 304
            ...|..:..|||||....|||:....|.     .|.....:.|....::...:...:....|.::
 Worm   338 TTTFHRTPPMSTYLFAFSVSDYPYLETF-----SGRGVRSRVYCDPTKLVDAQLITKSIGPVLDF 397

  Fly   305 YIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAH 369
            |..|:.:||||.|||:..:|..:..|||:|||:|.|:|..||.....:.:.|..:...:|||:||
 Worm   398 YEDYFGIPYPLEKLDVVIVPALSVTAMENWGLITIRQTNGLYTEGRFAISQKHDVQEIVAHELAH 462

  Fly   370 QWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAV-HPDWGMLEQFQIVALQPVLLYDAKLSSHPIV 433
            ||||||||||||||||||||||..:..:.|:.: :..|    :::          |:...|..:.
 Worm   463 QWFGNLVTMKWWNDLWLNEGFATLISVRAVDFLENTTW----RYE----------DSSAESQCVA 513

  Fly   434 QKVESPDEITAI-------FDT--------ISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQF 483
            .:.:..|.|:.:       ||:        |.|:|...:|||:|.||..:.|.:.:..:|....:
 Worm   514 LRADQIDSISPVSGKKNSNFDSYMEIQGKAIIYKKSAIIIRMIERLVEEDIFRQGLKRFLNTFLY 578

  Fly   484 NNTVTDDFLTEVEAVVTD-----------LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRF 537
            .|...:| |..|...|.|           ..:..:|.||..|..:||::|:: .:||....:|.
 Worm   579 KNADHED-LFNVLVYVHDSSAGGHLRGQNFSLSDVMDTWIRQAHFPVIHVNR-KEGSLVTLRQE- 640

  Fly   538 LSNPASYEEAPSDSAYGYKWSVPITWFADD---GSENSF--------IYDYDVDSVGIAVPSEVQ 591
                 .||..|.|......|.:||  |.||   |....|        ::|..    |:.|
 Worm   641 -----KYEHVPRDEPEKQVWKIPI--FYDDPVSGKHKVFWLTDTQPKVFDMG----GLLV----- 689

  Fly   592 WIKLNVNQTGYYRVNYEESLWA----LLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIP 652
               ::.:|..|.|:.|:..:::    .|:...|..|..    .|..|::|..|:|:..||:||:|
 Worm   690 ---VDPHQLTYMRLRYDMEMYSDITMALMDDFTMIPTN----SRSRLIDDTLAMAENGQLTYKVP 747

  Fly   653 LDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGV----YEEVGWTVDAD 713
            .::|.|:::|..:.|:...|..|......:...||:..|..|. .|:.|:    :...|..|..|
 Worm   748 FNLTMYMSREIAYRPFQTFSAYLDFFLPRMYIHEGWSIYKKYL-ELVVGIPFDKFNAEGLDVSFD 811

  Fly   714 NHLK-NRLRVSILTAACALGVPDCLQQASERFSTFLEN-----------PTTRPSPDLREIVYYY 766
            ::.. ...|..::..||.:....|::.|.:||:....|           ...:....||..||..
 Worm   812 HNTDLFHTRQIVVFRACGIEYEPCVRMAKQRFAELRVNCSGENQLLSGMECNKIPYYLRPHVYSA 876

  Fly   767 GMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGL--SGVR-NSQYLFDFLAQASSDESI-VRSQD 827
            .:...| |..:|.|::.::.|....|...:..||  :.:| ||...:..:.:..:.|:: ||:|
 Worm   877 AINDGT-QEDFDFLYKKWMIEHYMMEHDNIFTGLCTTNIRENSDRAWRQVIKNGARENVMVRAQ- 939

  Fly   828 YFTCVQYIAANPVGEPVVWE--FYREQWPQLTTR--FGLNNRNFGRLIAQITANFASSV-KLEEV 887
              .|.:.::.|.....:::|  .|.:::.....:  |.|....:.::      |:...| |.:||
 Worm   940 --LCSKKLSKNNFILDLLYEDKVYLKEFVDKDRKSLFALQQLLYRKI------NYEEEVLKADEV 996

  Fly   888 QHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEA---DITDWLSGTASPLT 937
               |..||:                  :.|:.:..|   |..||....|:..|
 Worm   997 ---FKPYPQ------------------LRWIPKLRAIASDRLDWRKTVAAQFT 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	138/479 (29%)
		ERAP1_C	592..912	CDD:463368	73/348 (21%)
Y42A5A.1	NP_505820.1	M1_APN-Q_like	160..618	CDD:341064	138/479 (29%)
		ERAP1_C	687..>939	CDD:463368	59/265 (22%)