DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and pam-1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	901	Identity:	284/901 - (31%)
Similarity:	447/901 - (49%)	Gaps:	74/901 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNR---EVEK 128
            ||||...||||.:...|.|...:|.|...|.:.:.|||:.:.:|:..|.|.||.::.:   ..:.
Worm    79 RLPTFAEPTHYNVRLSPCLNQFSFDGHATIDVTIKEATDVLKVHAQSLLIQSVSLITQPGDASKS 143

  Fly   129 FELEEERQFLIITLTEELAVD-ASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPT 192
            .|...:.:..|:|:.....:. ..:.|...|.|::.||:.|.|.|.|.::.|..:.:::|:||.|
Worm   144 LETSYDDKLNILTIKLPTTMQPQKVQLDFKFVGELNDKMRGFYRSQYKDKNGTEKFLASTQFEST 208

  Fly   193 YARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD-YTEAI-FETSVSMSTYLVC 255
            |||.||||||||..||||.:| :.......|:|||.........| ..:|: |.||..||:|||.
Worm   209 YARYAFPCFDEPIYKATFDVT-LEVENHLTALSNMNVISETPTADGKRKAVTFATSPKMSSYLVA 272

  Fly   256 IIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDM 320
            ..|.:....|...| :|:    .|:.|....:..:.:::|:......::|.:::.:.|||.|.|:
Worm   273 FAVGELEYISAQTK-SGV----EMRVYTVPGKKEQGQYSLDLSVKCIDWYNEWFDIKYPLPKCDL 332

  Fly   321 AAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLW 385
            .|||||:.||||:||||||||.|||.||..:||..|..:|..:|||:||.|||||||||||.|||
Worm   333 IAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVALVVAHELAHLWFGNLVTMKWWTDLW 397

  Fly   386 LNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTIS 450
            |.||||.:|:|..|.|..|::.:...|....|...:..||..:||||..::::|:|:..|:|:|:
Worm   398 LKEGFASFMEYMFVGANCPEFKIWLHFLNDELASGMGLDALRNSHPIEVEIDNPNELDEIYDSIT 462

  Fly   451 YEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTWTEQM 515
            |.|..||.|||...:....|::.:..||.:.|::|.||.|..|.: :..:..::.:||..||:||
Worm   463 YAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQDLWTAL-SEASGQNVNELMSGWTQQM 526

  Fly   516 GYPVLNVSKVADGS---FKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFI--- 574
            |:|||.||:..||:   ..|.|:||:|:..   |.|.:|    :|.||||  ...||..|.:
Worm   527 GFPVLKVSQRQDGNNRILTVEQRRFISDGG---EDPKNS----QWQVPIT--VAVGSSPSDVKAR 582

  Fly   575 -------YDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRG 632
                   .::.::.|   .|.|  |:|||...||:|||.|.:.:...::..:.:  .|..:.||.
Worm   583 FLLKEKQQEFTIEGV---APGE--WVKLNSGTTGFYRVEYSDEMLTAMLPDIAS--RRMPVLDRF 640

  Fly   633 HLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYV---ASNKLRSLHRSLMFSEGYVSYLTY 694
            .|:||..||.:..::|....:.:.|..|:|.::|.|..   ..:||.:..|.:  ||   ..|..
Worm   641 GLINDLSALLNTGRVSIAQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAREM--SE---DTLKS 700

  Fly   695 ARSLIAGVYE----EVGWTVDA-DNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTR 754
            |:.|:..::|    |:|:...| ::..|..||..:.......|....:.:.::.|:.|||..|
Worm   701 AKQLVVKMFEQTGAELGFAEQAGEDSQKMMLRSLVQARLARAGHQPTIDKFTQMFNDFLEKGT-- 763

  Fly   755 P-SPDLR----EIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLA 814
            | .||:|    .:|..||     .:..:|:|..|....|....:.:.|..:|.......|.. |.
Worm   764 PIHPDIRLATFGVVARYG-----GKEGFDKLMNLRETTTFQEIERQTMVAMSQTPEESLLAQ-LF 822

  Fly   815 QASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRF-GLNNRNFGRLIAQITANF 878
            :...:::.||.||.........|..:|:...|:::.|...:...:: |.|:..|.|.:.....:|
Worm   823 EYGFEKNKVRPQDQLYLFLGTGATHMGQQYAWKYFCEHIKEFLDKYGGANSSLFQRCLKFAGESF 887

  Fly   879 ASSVKLEEVQHFFSKYPESGAGANSRL-----EAVETIKYNIEWLSRNEADITDWL 929
            .:..:..|.|.||.............|     :.||.|:.|...|..|...|.:.|
Worm   888 GNEKRAVEFQDFFCNCNVLSDTDRQTLARPIGQTVEAIRLNARLLESNRQIIENLL 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	150/392 (38%)
		M1_APN_2	75..518	CDD:189008	167/448 (37%)
		ERAP1_C	593..910	CDD:288671	78/335 (23%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	167/448 (37%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	81/339 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020