Protein Alignment CG8774 and T16G12.1

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_499230.2
• Gene: T16G12.1 / 176416
• WormBaseID: WBGene00011803
• Length: 1890
• Species: Caenorhabditis elegans
• Alignment Length: 1024
• Identity: 248/1024 - (24%)
• Similarity: 423/1024 - (41%)
• Gaps: 202/1024 - (19%)

  Fly    29 QKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTDYRLPT------NLV---PTHYEL----- 79
            |.:.|...|....|:.|:|:.:.  :|..:..|..:.|.|||      |||   .|.:|.
 Worm   937 QLSTLMNTLTLTNDQFDIFDFYI--NRVSLMFEYKSTYALPTYNWLYDNLVVIGKTPWEKTPNID 999

  Fly    80 ----YWHPDL-------------ETGNFTGQQRISIKVVEATNQIIL--HSYLLDITSVYVLNRE 125
                |:..||             |...|:....::.::|..|:.|.:  |..:.|..|:.:.|..
 Worm  1000 AVFPYYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVSPTSSITINAHRLMFDPVSIRLYNEN 1064

  Fly   126 VEKFELE------------EERQFLIITLTEELAVDASITLGIIFGG---QMKDKLVGLYSSTYL 175
            .|.....            ::....|.|:...:......:|.|.:.|   |..|:  |..|:|||
 Worm  1065 DENAHTPIPIDFSKVMKDYDKGTVTIPTMNNTVLYPNQYSLFIEYTGFIFQNPDE--GDASNTYL 1127

  Fly   176 ----NEAGATRTISTTKFE--PTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSN---MQQTE 231
                |..|   .|.||.||  |. ||...||:|||:.|..|.::|.||:... |:||   :|:|
 Worm  1128 GGLNNRKG---WIFTTDFEGGPG-ARSLLPCWDEPSYKGQFEVSVFHPTDMI-ALSNEVDIQRT- 1186

  Fly   232 SNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFS---MQAYATSHQINKVEF 293
             .|...:|...|.|:..|||||:.:.|..|::.:|..:...:...::   |:.|.        ||
 Worm  1187 -IYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRTGVLTRVWTWSGMEQYG--------EF 1242

  Fly   294 ALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFA--SGAMEHWGLVTYRETALLYDPSYSSTANK 356
            ||.......::...|:...:||.|||:.|:|::.  :||||:|||:....:..::||.|::|.:.
 Worm  1243 ALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDYATTRDI 1307

  Fly   357 QSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHP-------DWGMLEQFQI 414
            ..:|.|.|||:.|||||::||:.||||::||||||:|....|::...|       |:.......|
 Worm  1308 TEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNRFYMNHI 1372

  Fly   415 VALQPVLLYDAKLSSHPIVQKVESP--DEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNY 477
                 .|.||.       :..|..|  .:...:|....|.||.:::.:|..::....|:|.:::|
 Worm  1373 -----ALKYDC-------IPGVAKPVISDTPPVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSY 1425

  Fly   478 LVKHQFNNTVTDDFLTEVEAV-----VTD-----LDIKKLMLTWTEQMGYPVLNVSKVADGSFKV 532
            |.::.:.|....:..|.:...     :||     ||:...|..:|.|..||::.::.....:.:.
 Worm  1426 LTQYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLTLRGTSTVQA 1490

  Fly   533 TQQRFLSNPASYEEAPSDSAYGYKWSVPI----------TWFAD--DGSENSFI----YDYDVDS 581
            .||..:|:..             .|:||:          .||.:  .|::.:::    ..|.||:
 Worm  1491 NQQSCMSDET-------------LWNVPLFTQTPGALDFNWFVNFTGGNDATWLRPLPTGYRVDN 1542

  Fly   582 VGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQ 646
            .|               .|.:.|:||::..|..:..||.::........|..||:||.....:.:
 Worm  1543 AG---------------STSFARINYDDKSWYSIQAQLLSNMNTMSSTTRAMLLDDANFFYQSGR 1592

  Fly   647 LSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVD 711
            ......||:|.||..|....||..|......:.....:.....:...|...:......:..|..:
 Worm  1593 WEMTKFLDLTLYLVNEDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVSKFQWNTN 1657

  Fly   712 ---ADNHLKNRLRVSILTAACALGV-PDCLQQASERFSTFL------ENPTTRPS---PDLREIV 763
               |::.:     |.:|.....|.| ....|.|...|:.|:      .:.|.:.|   |:||:..
 Worm  1658 GLWANDRI-----VQLLVNVNNLAVNRQSRQVALTLFNNFVLKCKYSLSGTGKCSGIHPNLRQPT 1717

  Fly   764 YYYGMQQSTSQSSW---DQLFQLFV-----AETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDE 820
            |.||::||.:...:   :.|:..||     .:||.|   .|:..|..|:|..      .|.:...
 Worm  1718 YCYGLRQSNNIDDFTTVNNLYSWFVQNAGYLQTDGS---NLLNALGCVQNLD------LQKTMLR 1773

  Fly   821 SIVRSQDY-FTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNR-NFGRLIAQITANFASSVK 883
            ||: |.|| .:.:..||.:.....|::.|..:     .|:..||.. :|...:..:..|:::|.:
 Worm  1774 SIL-SGDYPPSLLNSIAVHDDSSDVLYNFLLD-----NTQDILNAPFDFSLYVKAMFQNWSTSNQ 1832

  Fly   884 LEEVQHF--FSKYP-ESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            ||..:.|  .|.|. .:.|..|...:.:.|:..|..|:...:....:|:
 Worm  1833 LELAKDFQNSSNYNLLNAAQKNIYKQGILTVNSNANWMLIYKTPFLEWI 1881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	137/509 (27%)
		ERAP1_C	592..912	CDD:463368	76/345 (22%)
T16G12.1	NP_499230.2	M1_APN-Q_like	90..544	CDD:341064
		ERAP1_C	639..931	CDD:463368
		M1_APN-Q_like	1005..1471	CDD:341064	134/494 (27%)
		ERAP1_C	1542..1839	CDD:463368	71/331 (21%)