DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and mnp-1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_497878.1	Gene:	mnp-1 / 175564	WormBaseID:	WBGene00007139	Length:	781	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	147/717 - (20%)
Similarity:	255/717 - (35%)	Gaps:	202/717 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VAFATAT----VVVAVQKAQLERDLRDVQDKIDVFE--EWSGE------SRTRMKREDTTDYRLP 69
            |...|||    :|:.|..|.:      ::||...||  |...|      |.|..:...|:|   |
Worm   117 VPTTTATDAPEIVMPVDVASI------LKDKTKDFEIVEKCAEIQALPVSCTPSQSPLTSD---P 172

  Fly    70 TNLVPTHYEL------YWHPDLETGNFTGQQRISIKVVEATNQIILHSY----LLDITSVYVLNR 124
            :...|.||.|      ...|.||     |..::.....:....|.|||.    |.:...::|:|.
Worm   173 SKFQPIHYVLNITIRDVRKPVLE-----GHMQLFASTKDQVQAISLHSVKIHNLENRDRIHVVNC 232

  Fly   125 EVEKFELEEERQFLIITLTEELAVDASITL----GIIFGGQMKDKLVGLYSSTYLNEAG--ATRT 183
            ...:          .|.::....:|..|.|    .|..|..::..:.|..|:    ::|  ..:.
Worm   233 NTGE----------TICVSRVHQIDDLIHLELAQSISSGVNLRVDIDGFISA----DSGPHVFKQ 283

  Fly   184 ISTTK----------FEPTYARQAFPCFDEPAMKATFAITVVH-PSGSYHAVSNMQQTESNYLGD 237
            |.|.|          ||||.||..||.||....|:||.:.:.| ||.|..|.|.:....|
Worm   284 IPTAKWRVPQMIGSVFEPTSARHVFPSFDLHNQKSTFNLCLNHGPSMSAIANSLINPNVS----- 343

  Fly   238 YTEAI--FETSVSMSTYLVCIIVSDFAS----QSTTVKANGIGE---DFSMQA-----YATSH-Q 287
             |..|  ||.:|.:....:..:..:..:    .:||:....:.|   .|::.|     |...| :
Worm   344 -TSGISCFEKTVPLIAQQLSFVAFEKTNPLFYNTTTMDGAYLPEIDMIFNLNAKNFKQYEWIHSE 407

  Fly   288 INKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSS 352
            ::||...:.          ::....||||:|::...|  ........|::|....|:.|. .::|
Worm   408 VSKVMALMS----------KWSGFSYPLTRLEIVVAP--VQAGHSALGVITLPAQAIAYQ-KHTS 459

  Fly   353 TANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIV-- 415
            |..      ||..|:..||...:||             ..:..::.....:.:|.:.|:.|||
Worm   460 THE------TLIKEVIGQWMEGVVT-------------TEHTCFEKALIAYVEWKINEELQIVKK 505

  Fly   416 -------ALQPVLLYDAKLSSHPIVQKVESPD------EITAIFDTISYEKGGSVIRMLETLVGA 467
                   .::|..|.:. ..|..::::::|..      ....:|.|:....|      .||::|.
Worm   506 TRKMEVSKIRPRNLNET-ADSVRVLRQIKSQSSNLCSPRFVEVFYTLDETYG------QETVIGM 563

  Fly   468 EK--FEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDL-DIKKLMLTW---TEQMGYPVLN--VSK 524
            .:  |:        |..|:.....|:.:..|...... :...|:..|   :..:..|||.  ||
Worm   564 IRVIFD--------KFAFSTATISDWASAAETATGGRPEAGALIHQWYRPSSTISRPVLRAVVS- 619

  Fly   525 VADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSE 589
                          ||...:.:...::     |:||:......|::             :||.||
Worm   620 --------------SNSVEFNQLTEET-----WTVPLEISGSAGTQ-------------LAVISE 652

  Fly   590 VQ---------WIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADAN 645
            .:         ::.::..:..:..|.|:...:..||:....|  |....:.|.:.:|..|...||
Worm   653 KKQAIPFVSSDYVVVDAGRKSHAFVVYDADTYLRLIRCFGDS--RCPSKEIGGIFSDLGAALLAN 715

  Fly   646 QL 647
            .|
Worm   716 IL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	92/443 (21%)
		M1_APN_2	75..518	CDD:189008	101/505 (20%)
		ERAP1_C	593..910	CDD:288671	12/55 (22%)
mnp-1	NP_497878.1	Peptidase_M1	172..556	CDD:279741	92/441 (21%)
		GluZincin	<294..>480	CDD:301352	53/223 (24%)
		GluZincin	<547..602	CDD:301352	12/68 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910