Protein Alignment CG8774 and F49B2.6

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_493503.2
• Gene: F49B2.6 / 173297
• WormBaseID: WBGene00009865
• Length: 1082
• Species: Caenorhabditis elegans
• Alignment Length: 946
• Identity: 287/946 - (30%)
• Similarity: 467/946 - (49%)
• Gaps: 90/946 - (9%)

  Fly    28 VQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDT--TDY--RLPTNLVPTHYELYWHPDLETG 88
            |::.:.|.:..:.:::   .||.|||...:..:|.|  |.|  |||....|..|:|..||:|..|
 Worm   159 VEEVEEEEEHEETEEQ---EEEQSGEKFVKANKECTNITWYSSRLPRTAEPIDYDLTLHPNLTNG 220

  Fly    89 NFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFELEEERQFL---IIT-----LTEE 145
            .......|.|.:...|..:||::..|::.|.     ::.|...:.:..|:   ::|     |.:.
 Worm   221 EVEASVSIRILIKNDTKLLILNAENLEMKSF-----DITKKGAKVKADFVKCAVMTQWAWKLAKR 280

  Fly   146 LAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATF 210
            |.....|.|.|.:..|||..|.|||.||:|...|.....:.|:||||:||:..||||||..||||
 Worm   281 LHKGDHIVLTIYYSAQMKSDLQGLYFSTHLGTDGKKTKSAATQFEPTFARKMLPCFDEPNFKATF 345

  Fly   211 AITVVHPSGSYH-AVSNMQ-QTESNYLGDYTEAIFETSVSMSTYLVCIIVSD---FASQST--TV 268
            .:.::.  ..:| |.|||. .....|.....:.:||.||.|||||:.:.|.|   :..:.|  |.
 Worm   346 QVAIIR--NPHHIARSNMNILISKEYKNGLIKDVFEKSVKMSTYLLAVAVLDGYGYIKRLTRNTQ 408

  Fly   269 KANGIGEDFSMQAYATSHQI-NKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAME 332
            ||      ..::.||....: .:.||.|:......|::..|:.:.|||.|:|:.|:.||:.||||
 Worm   409 KA------IEVRLYAPQDMLTGQSEFGLDTTIRALEFFEDYFNISYPLDKIDLLALDDFSEGAME 467

  Fly   333 HWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYK 397
            :|||||:|::|||::...:|...|:.||..:.||||||||||||||.|||:::||||||.||:||
 Worm   468 NWGLVTFRDSALLFNERKASVVAKEHIALIICHEIAHQWFGNLVTMDWWNEVFLNEGFANYMEYK 532

  Fly   398 GVNAVHPDWGMLEQFQIVAL----QPVLLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVI 458
            .|..:.|||.::.:|....|    :|    |..|||..|  :.:..|.:..:||.|:|.|..::|
 Worm   533 CVEHLFPDWSIMSRFYAENLAFSQEP----DGFLSSRAI--ESDDDDSLLNLFDAINYHKAAAII 591

  Fly   459 RMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEA---VVTDLDIKKLMLTWTEQMGYPVL 520
            .|:..:.|.:.|:.|:..||.|:.::|.:..|....||.   :...:.|..|...:|.|:|||:|
 Worm   592 HMIAEMAGQKNFQNALVEYLNKYAYSNAIGVDLWKIVEKHANLQGTVSIPDLAKAYTTQVGYPLL 656

  Fly   521 NVSKVADGSFKVTQQRFL-SNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGI 584
            .|.:..:|.....|.||| :.....||...|    :||.:||: :.|........:....|...:
 Worm   657 TVERTDEGVLVHNQTRFLFAEGDKAEEKRGD----WKWPIPIS-YRDSEHRRKKQHWIQADDKNV 716

  Fly   585 A-VPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLS 648
            . ..:...|:.||....||::|.|:...:..|::||..:.......||..:|.|:|.|:..:.|:
 Worm   717 TWETTSNDWLILNTGGVGYFKVLYDPETYRKLVKQLQRNHTTISPIDRSMILVDSFDLSKTSLLN 781

  Fly   649 YKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDAD 713
            ..:..|:..|:.:|.|.:.|.:...:||::...:..|:....|..:.||||..:||.:.|.....
 Worm   782 ISVYFDLLEYVEKETDKMTWSIVGKQLRTIEALIEESDYLDIYQDFQRSLIMRLYESLDWDEQGA 846

  Fly   714 NHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWD 778
            |..:.||:|.|...||.|.:.||.:||.:|:..::.:....|...:  |....|::|..: ::|:
 Worm   847 NPNQKRLQVDIFAVACRLQIKDCTKQAYQRYLQWVSSGVRNPEHHM--IALMEGVKQGET-TAWE 908

  Fly   779 QLFQLFVAETDASEKLKLMYGLSGVRNS-------QYLFDFLAQASSDESIVRSQDYFTCVQYIA 836
            ::::.:...|..|||..::..|:..:::       :|..|...:|:   .|.|...||      :
 Worm   909 RIWKAYKTATSPSEKNNIIGALTSTKDASLINRLLKYCLDGKIKAN---LIPRVFSYF------S 964

  Fly   837 ANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQ----ITANFASSVKLEEVQHFF--SKYP 895
            .|.....:||:|::..:.|.....|.     |.|:|.    :....::..:||||:.|.  .|:.
 Worm   965 LNQSTRNIVWKFFKTHFEQFHGILGK-----GSLMASCVKCLAEPLSTETELEEVKEFLKSQKFA 1024

  Fly   896 ESGAGANSRLE-AVETIKYNIEWLSRNEADITDWLS 930
            |.|.   .::| ..|.|:.||:|...||..:..|:|
 Worm  1025 EDGL---IKMEMTYEQIELNIQWRKLNEGQLGKWIS 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	161/460 (35%)
		ERAP1_C	592..912	CDD:463368	82/333 (25%)
F49B2.6	NP_493503.2	M1_APN-Q_like	209..649	CDD:341064	161/458 (35%)
		ERAP1_C	725..1024	CDD:463368	78/315 (25%)