DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8774 and Lnpep

DIOPT Version :10

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_001106874.1 Gene:Lnpep / 171105 RGDID:621752 Length:1025 Species:Rattus norvegicus


Alignment Length:883 Identity:300/883 - (33%)
Similarity:468/883 - (53%) Gaps:44/883 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLN------RE 125
            ||||.::|..|||..||:|.:..|.|...||::.::.|..|||||...:|:||..::      ::
  Rat   167 RLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQ 231

  Fly   126 VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFE 190
            ||..|.....|..::. .|.|....:.||.|.:...:.:...|.|..||.:::...:..:.|:||
  Rat   232 VEILEYPYHEQIAVVA-PESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFE 295

  Fly   191 PTYARQAFPCFDEPAMKATFAITVVHPSGSYH-AVSNMQQ-----TESNYLGDYTEAIFETSVSM 249
            |..||.|||||||||.||||.|.:..  ..:| |:|||.:     ||...:.|.    |..||.|
  Rat   296 PLAARSAFPCFDEPAFKATFIIKITR--DEHHTALSNMPKKSSVPTEEGLIQDE----FSESVKM 354

  Fly   250 STYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYP 314
            |||||..||.:..:.|..|  ||.    .:..||...:|::|..||:....:.|:|..|:::.||
  Rat   355 STYLVAFIVGEMRNLSQDV--NGT----LVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYP 413

  Fly   315 LTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMK 379
            |.|||:.|||||.:||||:|||:|:||..||||.:.||.|:::.:...:|||:|||||||||||:
  Rat   414 LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQ 478

  Fly   380 WWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITA 444
            ||||||||||||.:|:|..|..:..:....|.| :.|....:..|:..|||||...|:|.::|..
  Rat   479 WWNDLWLNEGFATFMEYFSVEKIFKELNSYEDF-LDARFKTMRKDSLNSSHPISSSVQSSEQIEE 542

  Fly   445 IFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVV-TDLDIKKLM 508
            :||::||.||.|::.||::.:..:.|:.|:..||..|.:....:||.......|. ..||:||:|
  Rat   543 MFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMM 607

  Fly   509 LTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFAD--DGSEN 571
            .|||.|.|:|::.|.:... ...:.|:||.  |:...|. .||...:.|.:||::..|  :.||.
  Rat   608 KTWTLQKGFPLVTVQRKGT-ELLLQQERFF--PSMQPEI-QDSDTSHLWHIPISYVTDGRNYSEY 668

  Fly   572 SFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLN 636
            ..:...|..|..|.:..:|||:|:|.|.||||.|:|....||.||.||..:|......||.:|:|
  Rat   669 RSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLIN 733

  Fly   637 DAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVS----YLTYARS 697
            :.|.||...::..::..|:..||..|....|...|..:...:: :|:...|::.    .:|....
  Rat   734 NIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIY-NLLEKLGHMDLSSRLVTRVHK 797

  Fly   698 LIAGVYEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSP-DLRE 761
            |:....::..|| |........||.::|..|||..:.:|...|::.|..::.:..|:..| |:..
  Rat   798 LLQNQIQQQTWT-DEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMT 861

  Fly   762 IVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQ 826
            .|:..|   :.::..|..||.::.:....:||.|::..|:...::..|: :|.::|.|..|:|:|
  Rat   862 TVFKVG---ARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLY-WLMKSSLDGDIIRTQ 922

  Fly   827 DYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFF 891
            .....::.:.....|..:.|:|.:|.|.:|..:|.|.:.....::|..|..|::...|.|||.||
  Rat   923 KLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFF 987

  Fly   892 SKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            ....|:........||.|.|:.||:|::||...:|.||
  Rat   988 ENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 M1_APN-Q_like 75..513 CDD:341064 177/450 (39%)
ERAP1_C 592..912 CDD:463368 86/324 (27%)
LnpepNP_001106874.1 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding. /evidence=ECO:0000250 96..101
M1_APN-Q_like 176..612 CDD:341064 177/449 (39%)
ERAP1_C 689..1009 CDD:463368 87/325 (27%)
Blue background indicates that the domain is not in the aligned region.

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