DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8774 and Lta4h

DIOPT Version :9

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_032543.2 Gene:Lta4h / 16993 MGIID:96836 Length:611 Species:Mus musculus


Alignment Length:636 Identity:137/636 - (21%)
Similarity:227/636 - (35%) Gaps:168/636 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 DTTDYRLPTNLVPT-HYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSV----YV 121
            ||.....|.::..| |..|....|......||...::::..|..    |.|..||...:    .|
Mouse     6 DTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEEN----LRSLTLDTKDLTIEKVV 66

  Fly   122 LNREVEKFELEEERQF----LIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATR 182
            :|.:..|:.|.|.:.:    :.|:|...|:.:..|.:.|.|  :...|...|...|....:|...
Mouse    67 INGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISF--ETSPKSSALQWLTPEQTSGKQH 129

  Fly   183 TISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAI--FET 245
            ....::.:..:.|...||.|.|::|.|:...|..|......:|.::..|:....|.:..|  |..
Mouse   130 PYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQ 194

  Fly   246 SVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYI--QY 308
            .|.:..||:.::|.  |.:|..:....:......|...::::.::.|..|:..:.:...|:  ||
Mouse   195 RVPIPCYLIALVVG--ALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQY 257

  Fly   309 YKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFG 373
            ..:..|         |.|..|.||:..|.....|.|         |..:|::..:||||:|.|.|
Mouse   258 DLLVLP---------PSFPYGGMENPCLTFVTPTLL---------AGDKSLSNVIAHEISHSWTG 304

  Fly   374 NLVTMKWWNDLWLNEGFARYMQ-----------YKGVNAVHPDWGMLEQFQIVALQPVLLYDAKL 427
            ||||.|.|:..|||||...|::           ::..:|: ..||.|:       ..:..:.   
Mouse   305 NLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHAL-GGWGELQ-------NTIKTFG--- 358

  Fly   428 SSHPIVQ-----KVESPDEITAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYLVKHQFNNT 486
            .|||..:     |...||   ..:.:|.||||.:::..||.|:|. |.|...:..|:.|..:.:.
Mouse   359 ESHPFTKLVVDLKDVDPD---VAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSV 420

  Fly   487 VTDD--------FLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPAS 543
            .|||        |..:|: ::..:|..    ||....|.|.:..                     
Mouse   421 TTDDWKSFLYSHFKDKVD-LLNQVDWN----TWLYAPGLPPVKP--------------------- 459

  Fly   544 YEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYE 608
                                            :|||......:....:|:...           |
Mouse   460 --------------------------------NYDVTLTNACIALSQRWVTAK-----------E 481

  Fly   609 ESLWALLIQQLTTSPARFEIAD----RGHLLNDAFALADANQLSYKIPLDM 655
            |.|            :.|.|||    ..|.||:..|     |:..|.||.:
Mouse   482 EDL------------SSFSIADLKDLSSHQLNEFLA-----QVLQKAPLPL 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 Peptidase_M1 67..454 CDD:279741 96/415 (23%)
M1_APN_2 75..518 CDD:189008 114/480 (24%)
ERAP1_C 593..910 CDD:288671 15/67 (22%)
Lta4hNP_032543.2 leuko_A4_hydro 6..608 CDD:274120 137/636 (22%)
M1_LTA4H 6..450 CDD:189006 116/488 (24%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960 135..137 0/1 (0%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960 267..272 1/4 (25%)
Leuk-A4-hydro_C 468..607 CDD:286244 16/76 (21%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960 564..566
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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