Protein Alignment CG8774 and Lta4h

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 636
• Identity: 137/636 - (21%)
• Similarity: 227/636 - (35%)
• Gaps: 168/636 - (26%)

  Fly    62 DTTDYRLPTNLVPT-HYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSV----YV 121
            ||.....|.::..| |..|....|......||...::::..|..    |.|..||...:    .|
Mouse     6 DTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEEN----LRSLTLDTKDLTIEKVV 66

  Fly   122 LNREVEKFELEEERQF----LIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATR 182
            :|.:..|:.|.|.:.:    :.|:|...|:.:..|.:.|.|  :...|...|...|....:|...
Mouse    67 INGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISF--ETSPKSSALQWLTPEQTSGKQH 129

  Fly   183 TISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAI--FET 245
            ....::.:..:.|...||.|.|::|.|:...|..|......:|.::..|:....|.:..|  |..
Mouse   130 PYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQ 194

  Fly   246 SVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYI--QY 308
            .|.:..||:.::|.  |.:|..:....:......|...::::.::.|..|:..:.:...|:  ||
Mouse   195 RVPIPCYLIALVVG--ALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQY 257

  Fly   309 YKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFG 373
            ..:..|         |.|..|.||:..|.....|.|         |..:|::..:||||:|.|.|
Mouse   258 DLLVLP---------PSFPYGGMENPCLTFVTPTLL---------AGDKSLSNVIAHEISHSWTG 304

  Fly   374 NLVTMKWWNDLWLNEGFARYMQ-----------YKGVNAVHPDWGMLEQFQIVALQPVLLYDAKL 427
            ||||.|.|:..|||||...|::           ::..:|: ..||.|:       ..:..:.
Mouse   305 NLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHAL-GGWGELQ-------NTIKTFG--- 358

  Fly   428 SSHPIVQ-----KVESPDEITAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYLVKHQFNNT 486
            .|||..:     |...||   ..:.:|.||||.:::..||.|:|. |.|...:..|:.|..:.:.
Mouse   359 ESHPFTKLVVDLKDVDPD---VAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSV 420

  Fly   487 VTDD--------FLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPAS 543
            .|||        |..:|: ::..:|..    ||....|.|.:..
Mouse   421 TTDDWKSFLYSHFKDKVD-LLNQVDWN----TWLYAPGLPPVKP--------------------- 459

  Fly   544 YEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYE 608
                                            :|||......:....:|:...           |
Mouse   460 --------------------------------NYDVTLTNACIALSQRWVTAK-----------E 481

  Fly   609 ESLWALLIQQLTTSPARFEIAD----RGHLLNDAFALADANQLSYKIPLDM 655
            |.|            :.|.|||    ..|.||:..|     |:..|.||.:
Mouse   482 EDL------------SSFSIADLKDLSSHQLNEFLA-----QVLQKAPLPL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	113/475 (24%)
		ERAP1_C	592..912	CDD:463368	16/68 (24%)
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	137/636 (22%)