DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8774 and Anpep

DIOPT Version :9

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_032512.2 Gene:Anpep / 16790 MGIID:5000466 Length:966 Species:Mus musculus


Alignment Length:995 Identity:303/995 - (30%)
Similarity:508/995 - (51%) Gaps:97/995 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GYWLQVVLSWAVVAFATATV--VVAVQKAQLERDLRDVQDK--------------------IDVF 47
            |:::...|....:....|.|  ::|:.....:...|:.::.                    :|..
Mouse     4 GFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDES 68

  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGN-----FTGQQRISIKVVEATNQI 107
            :.|:             .||||..|:|..|.:...|.|...|     |.|...:.....:.|:.|
Mouse    69 KPWN-------------QYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVI 120

  Fly   108 ILHSYLLDIT---SVYVLNR--------EVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQ 161
            |:||..|:.|   :..|:.|        .::|.||.|..::|::.|...|.......:...|.|:
Mouse   121 IIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGE 185

  Fly   162 MKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSN 226
            :.|.|.|.|.|.|: |....:.::||:.:...||::|||||||||||.|.||:::|: :..|:||
Mouse   186 LADDLAGFYRSEYM-EGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPN-NLIALSN 248

  Fly   227 MQQTESN-YLGD--YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQI 288
            |...||. |..|  .|...|.::..|||||:..|||:|.:.| :|.|||:  ...:.|..::...
Mouse   249 MLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNIS-SVSANGV--QIGIWARPSAIDE 310

  Fly   289 NKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSST 353
            .:.::||.....:..::.|:|...|||.|.|..|:|||.:||||:||||||||::|::|...||.
Mouse   311 GQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSI 375

  Fly   354 ANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQ 418
            :||:.:...:|||:||||||||||:.||||||||||||.|::|.|.:...|.|.:.:...:..:.
Mouse   376 SNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVY 440

  Fly   419 PVLLYDAKLSSHPI---VQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVK 480
            .|:..||..||||:   ..::::||:|..:||:|:|.||.||||||.:.:..:.|::.:::||..
Mouse   441 RVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHT 505

  Fly   481 HQFNNTVTDDF-------LTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFL 538
            :|::|||..|.       :.:..||.....::.:|..|..|||:||:.|:   ..:.:::|:.||
Mouse   506 YQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVN---TNTGEISQKHFL 567

  Fly   539 SNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYY 603
            .:..|....||:  :.|.|..||. |...|.|:.:..|.:.:.......|..:||.||:|.||||
Mouse   568 LDSKSNVTRPSE--FNYIWIAPIP-FLKSGQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYY 629

  Fly   604 RVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPW 668
            .|||:|:.|..|..||.|..:...:.:|..:::|:|.||.|..:...:.||.|.:|.:|.:::||
Mouse   630 LVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPW 694

  Fly   669 YVASNKLRSLHRSLMF--SEGYVSYLTYARSLIAGVY-----EEVGWTVDADNHLKNRLRVSILT 726
            ..|.:.|.  :.:|||  ||.|.....|.:..:..::     ....|.......::....::.::
Mouse   695 QAALSSLN--YFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAIS 757

  Fly   727 AACALGVPDCLQQASERFSTFLENPTTRP-SPDLREIVY----YYGMQQSTSQSSWDQLFQLFVA 786
            .||:.|:.:|.....|.:|.:::||.... .|:||..||    .:|     .:..|:..::.|..
Mouse   758 TACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFG-----GEEEWNFAWEQFRN 817

  Fly   787 ETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYRE 851
            .|..:|..||...|:..::...|..:|:...:.: .:|.||..:.:..||:|..|.|:||:|.|.
Mouse   818 ATLVNEADKLRSALACSKDVWILNRYLSYTLNPD-YIRKQDTTSTIISIASNVAGHPLVWDFVRS 881

  Fly   852 QWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRL--EAVETIKYN 914
            .|.:|...:|..:.:|..||..:|..|:|..:|::::.|.:....:|.|..:|.  :|:|..:.|
Mouse   882 NWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRAN 946

  Fly   915 IEWLSRNEADITDWLSGTAS 934
            |:|:..|:..:..|.:..:|
Mouse   947 IDWVKENKDAVFKWFTENSS 966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 Peptidase_M1 67..454 CDD:279741 155/408 (38%)
M1_APN_2 75..518 CDD:189008 173/471 (37%)
ERAP1_C 593..910 CDD:288671 90/330 (27%)
AnpepNP_032512.2 Cytosolic Ser/Thr-rich junction 33..68 2/34 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..64 0/21 (0%)
Metalloprotease 69..966 295/928 (32%)
M1_APN-Q_like 84..545 CDD:341064 170/465 (37%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144 351..355 3/3 (100%)
ERAP1_C 618..945 CDD:403137 92/334 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3793
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.850

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