Protein Alignment CG8774 and Anpep

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_032512.2
• Gene: Anpep / 16790
• MGIID: 5000466
• Length: 966
• Species: Mus musculus
• Alignment Length: 995
• Identity: 303/995 - (30%)
• Similarity: 508/995 - (51%)
• Gaps: 97/995 - (9%)

  Fly     5 GYWLQVVLSWAVVAFATATV--VVAVQKAQLERDLRDVQDK--------------------IDVF 47
            |:::...|....:....|.|  ::|:.....:...|:.::.                    :|..
Mouse     4 GFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDES 68

  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGN-----FTGQQRISIKVVEATNQI 107
            :.|:             .||||..|:|..|.:...|.|...|     |.|...:.....:.|:.|
Mouse    69 KPWN-------------QYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVI 120

  Fly   108 ILHSYLLDIT---SVYVLNR--------EVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQ 161
            |:||..|:.|   :..|:.|        .::|.||.|..::|::.|...|.......:...|.|:
Mouse   121 IIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGE 185

  Fly   162 MKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSN 226
            :.|.|.|.|.|.|: |....:.::||:.:...||::|||||||||||.|.||:::|: :..|:||
Mouse   186 LADDLAGFYRSEYM-EGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPN-NLIALSN 248

  Fly   227 MQQTESN-YLGD--YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQI 288
            |...||. |..|  .|...|.::..|||||:..|||:|.:.| :|.|||:  ...:.|..::...
Mouse   249 MLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNIS-SVSANGV--QIGIWARPSAIDE 310

  Fly   289 NKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSST 353
            .:.::||.....:..::.|:|...|||.|.|..|:|||.:||||:||||||||::|::|...||.
Mouse   311 GQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSI 375

  Fly   354 ANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQ 418
            :||:.:...:|||:||||||||||:.||||||||||||.|::|.|.:...|.|.:.:...:..:.
Mouse   376 SNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVY 440

  Fly   419 PVLLYDAKLSSHPI---VQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVK 480
            .|:..||..||||:   ..::::||:|..:||:|:|.||.||||||.:.:..:.|::.:::||..
Mouse   441 RVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHT 505

  Fly   481 HQFNNTVTDDF-------LTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFL 538
            :|::|||..|.       :.:..||.....::.:|..|..|||:||:.|:   ..:.:::|:.||
Mouse   506 YQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVN---TNTGEISQKHFL 567

  Fly   539 SNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYY 603
            .:..|....||:  :.|.|..||. |...|.|:.:..|.:.:.......|..:||.||:|.||||
Mouse   568 LDSKSNVTRPSE--FNYIWIAPIP-FLKSGQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYY 629

  Fly   604 RVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPW 668
            .|||:|:.|..|..||.|..:...:.:|..:::|:|.||.|..:...:.||.|.:|.:|.:::||
Mouse   630 LVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPW 694

  Fly   669 YVASNKLRSLHRSLMF--SEGYVSYLTYARSLIAGVY-----EEVGWTVDADNHLKNRLRVSILT 726
            ..|.:.|.  :.:|||  ||.|.....|.:..:..::     ....|.......::....::.::
Mouse   695 QAALSSLN--YFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAIS 757

  Fly   727 AACALGVPDCLQQASERFSTFLENPTTRP-SPDLREIVY----YYGMQQSTSQSSWDQLFQLFVA 786
            .||:.|:.:|.....|.:|.:::||.... .|:||..||    .:|     .:..|:..::.|..
Mouse   758 TACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFG-----GEEEWNFAWEQFRN 817

  Fly   787 ETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYRE 851
            .|..:|..||...|:..::...|..:|:...:.: .:|.||..:.:..||:|..|.|:||:|.|.
Mouse   818 ATLVNEADKLRSALACSKDVWILNRYLSYTLNPD-YIRKQDTTSTIISIASNVAGHPLVWDFVRS 881

  Fly   852 QWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRL--EAVETIKYN 914
            .|.:|...:|..:.:|..||..:|..|:|..:|::::.|.:....:|.|..:|.  :|:|..:.|
Mouse   882 NWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRAN 946

  Fly   915 IEWLSRNEADITDWLSGTAS 934
            |:|:..|:..:..|.:..:|
Mouse   947 IDWVKENKDAVFKWFTENSS 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	170/466 (36%)
		ERAP1_C	592..912	CDD:463368	92/333 (28%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		2/34 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..64		0/21 (0%)
		Metalloprotease	69..966		295/928 (32%)
		M1_APN-Q_like	84..545	CDD:341064	170/465 (37%)
		ERAP1_C	618..945	CDD:463368	92/334 (28%)