Protein Alignment CG8774 and Enpep

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_031960.1
• Gene: Enpep / 13809
• MGIID: 106645
• Length: 945
• Species: Mus musculus
• Alignment Length: 913
• Identity: 355/913 - (38%)
• Similarity: 535/913 - (58%)
• Gaps: 74/913 - (8%)

  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSY 112
            |:.|||.:         ::|||..:.|.||:|.....:|...:||...||:.:.:.|..:.||..
Mouse    74 EDESGEWK---------NFRLPDFINPVHYDLEVKALMEEDRYTGIVTISVNLSKPTRDLWLHIR 129

  Fly   113 LLDITSVYVLNREVEK-------FELEEERQFLIITLTEELAV---DASITLGIIFGGQMKDKLV 167
            ...||.:..|.|...:       ||.::: ::::|...|:||.   |:...|.:.|.|.:...||
Mouse   130 ETKITKLPELRRPSGEQVPIRRCFEYKKQ-EYVVIQAAEDLAATSGDSVYRLTMEFKGWLNGSLV 193

  Fly   168 GLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTES 232
            |.|.:||: |.|..|:|:.|..|||.||::|||||||..|:|::|:::||. .|.|:|||.:.:|
Mouse   194 GFYKTTYM-EDGQIRSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHPK-EYSALSNMPEEKS 256

  Fly   233 NYLGD-YTEAIFETSVSMSTYLVCIIVSDFAS---QSTTVKANGIGEDFSMQAYATSHQINKVEF 293
            ..:.| :.:..|..||.|||||||..|..|.:   :|.:.|        .::.|...:|....|:
Mouse   257 EMVDDNWKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGK--------PLKVYVQPNQKETAEY 313

  Fly   294 ALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQS 358
            |....|||.:|:..|:.:.|.|.|||..|||||.:||||:|||||||||.|||||..|:::|:|.
Mouse   314 AANITQAVFDYFEDYFAMEYALPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQR 378

  Fly   359 IAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLY 423
            :|..:|||:.||||||.|||.||:|||||||||.:.::.|||....||.||.|..:..:.||...
Mouse   379 VASVVAHELVHQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKDWQMLSQVLLEDVFPVQED 443

  Fly   424 DAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVT 488
            |:.:||||:|..|.:|.|||::||.|||.||.|::|||:..:..|||::....||.|.||.|..|
Mouse   444 DSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANAKT 508

  Fly   489 DDFLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRF-LSNPASYEEAPSDSA 552
            .||...::. .::|.:|::|.|||.||||||:.||    |...:||:|| |.:.|...:.||:
Mouse   509 SDFWDSLQE-ASNLPVKEVMDTWTSQMGYPVVTVS----GRQNITQKRFLLDSKADPSQPPSE-- 566

  Fly   553 YGYKWSVPITWFADDGSENSFIYDYD-VDSVGIAVPSEVQ---WIKLNVNQTGYYRVNYEESLWA 613
            .||.|::|:.| ||  ::||.|..|: :|..||.:.:.:.   ::|:|.:..|:||||||...|.
Mouse   567 LGYTWNIPVRW-AD--NDNSRITVYNRLDKGGITLNANLSGDAFLKINPDHIGFYRVNYEGGTWD 628

  Fly   614 LLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPW--------YV 670
            .:.:.|:::..||..|||...::||||||.|..|:|||.|::|.||..|.||:||        |:
Mouse   629 WIAEALSSNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEEDFLPWERVISSVSYI 693

  Fly   671 ASNKLRSLHRSLMFS---EGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACALG 732
            .|          ||.   |.|....||.:..:..|.:.:||. |..:|:...||.|||..||.:|
Mouse   694 IS----------MFEDDRELYPMIETYFQGQVKPVADLLGWQ-DTGSHITKLLRASILGFACKMG 747

  Fly   733 VPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLM 797
            ..:.|..||:.|.::|:...:.| .:||.:||.||||.|.::::|:...:.:...:.|.||.||:
Mouse   748 DREALGNASQLFDSWLKGSASIP-VNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLL 811

  Fly   798 YGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGL 862
            |||:.|::.:.|..:| :...|.:|:::||.||.::||:.|..|:.:.|.:.:..|..|.:||.:
Mouse   812 YGLASVKDVKLLARYL-EMLKDPNIIKTQDVFTVIRYISYNSYGKTMAWNWIQLNWDYLVSRFTI 875

  Fly   863 NNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITD 927
            |:|..||::. |...|.:.::|.::|.||:|||.:||||..|.:.:||:|.|||||:.|...|.:
Mouse   876 NDRYLGRIVT-IAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLNVNRQSIRE 939

  Fly   928 WLS 930
            |.:
Mouse   940 WFA 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	187/451 (41%)
		ERAP1_C	592..912	CDD:463368	119/330 (36%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..77		1/2 (50%)
		M1_APN-Q_like	92..531	CDD:341064	186/450 (41%)
		ERAP1_C	607..925	CDD:463368	119/331 (36%)