Protein Alignment CG8774 and LOC1270378

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: XP_309093.5
• Gene: LOC1270378 / 1270378
• VectorBaseID: AGAMI1_011814
• Length: 1133
• Species: Anopheles gambiae
• Alignment Length: 1053
• Identity: 260/1053 - (24%)
• Similarity: 416/1053 - (39%)
• Gaps: 242/1053 - (22%)

  Fly    68 LPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFELE 132
            ||.|:.|..|.|..||:|.|.:..||..|.:.|.:.||.::||:..|:||...::.  .:.|.|:
Mosquito   126 LPNNVKPNRYILTIHPNLTTLDVKGQVSIELYVEKETNFVVLHAQDLNITEKALVG--PKGFALK 188

  Fly   133 -------EERQFLIITLTEELAVDASITLGIIFGGQM-KDKLVGLYSSTYLNEAGATRTISTTKF 189
                   ..||.|.|...|:|...|:.||.|.:..:| .|:..|        :....:|::.|..
Mosquito   189 ILRMLEYTPRQQLYIETREKLRKKANYTLSIRWHSKMILDQFEG--------DFDMKKTLAATVL 245

  Fly   190 EPTYARQAFPCFDEPAMKATFAITVVHPSGSYH-AVSN--MQQTE--SNYLG------DYTEA-- 241
            :|...|:||||||||.::|.|.|::..  ..:| .:||  :|.|:  ..|:|      |:.|.
Mosquito   246 KPGSTRKAFPCFDEPHLRAAFKISLFR--DRFHIGLSNSIVQDTDDVGFYMGTGLLRDDFAETPP 308

  Fly   242 IFETSVSMSTYLVCIIVSDFASQ----------------------------STTVKANG------ 272
            :...|||.       ::|||..:                            ||....||
Mosquito   309 LPPDSVSW-------VISDFRRELLEPSAKYQKVNASGNGASAAGAGKVPPSTAGAGNGKSTPSK 366

  Fly   273 -----------------------------------IGEDFSMQA--------------------- 281
                                               |..|.::.|
Mosquito   367 VTKTEKKPFRNLTAVLLSKNLFKLTNTAPTKEPTQIENDVTISAAESGPAVAKSNGTVLPEHDAL 431

  Fly   282 ----------------YATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGA 330
                            ||....|.|..|.|...:.:.||..|:..|.|||:|||..|:|......
Mosquito   432 WNGDTALIRTAPAYSFYAPETHIAKGTFILHTSRDILEYLQQWLSVAYPLSKLDFVALPSLLDDL 496

  Fly   331 MEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQ 395
            ....|::..| |:.|.:|:..|:.........::..|..|:||.|::.|.|...||.||..||:.
Mosquito   497 SSSLGIIVCR-TSFLNEPTAISSKEYHMSVVKISEGIVKQYFGGLISPKVWKHKWLWEGLIRYLS 560

  Fly   396 YKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPI-VQKVESPDEITAIFDTISYEKGGSVIR 459
            ...:..:.|.|.|.|.|.|..|...|..||......| ....:|.|.     |....:|..:::.
Mosquito   561 RFLLATIQPLWPMKELFLIDTLTKALDIDALQGWESISAGASDSGDN-----DPFYVDKSAALLS 620

  Fly   460 MLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLD-IKKLMLTWTEQMGYPVLNVS 523
            ||::.:|...|.:.:..:|..:||......|........|.:.. ::::|..||....:|:|||:
Mosquito   621 MLQSAIGERNFRQCLGKFLKTYQFQTAEPSDLWAICAKQVNNSKYVREMMNQWTNTAAFPLLNVT 685

  Fly   524 KVADGSFKVTQQRFLSNPASY--------EE---------------APSDSA-------YGYKWS 558
             :...|..|.|..|  .||.|        ||               ||.|:.       .|.:|.
Mosquito   686 -MNGTSLTVRQTGF--RPAEYLAIYDEPMEEIEREGEQGRSTTTTPAPVDATGKSGSGEAGTRWV 747

  Fly   559 VPITWF------------ADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESL 611
            .||.:.            |:...:.|.|...:...|.|.:....||||||..|||||||.|:|:.
Mosquito   748 FPIHYITDVLNTNETAAEAEHKEQQSLIIWLNSSEVIITLNHTAQWIKLNHGQTGYYRVLYDEAN 812

  Fly   612 WALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLR 676
            ||.|::|:..:.|.|...||..|::|.|.|..||.:.....:::.:|..:|:::.|..:.::.|.
Mosquito   813 WAKLVEQMQINNAVFSTQDRVGLVSDIFTLCHANLIPCHAAMELISYFPKEKEWGPIVLGTSHLE 877

  Fly   677 SLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQAS 741
            ...:.|.:||.|:....|.|..:|...:.:||....::..|....|.:|:||        |.:.|
Mosquito   878 KWRKILKYSECYLVLAEYVRQNLAKSIQVLGWDDTGEDETKLLRPVLMLSAA--------LWEES 934

  Fly   742 E--RFSTFLENPTTRPS----PDLREIVY----------YYGMQQSTSQSSWDQLFQLFVAETDA 790
            |  :|:..|....|..|    |:||.:.|          |:       |..||:...:...::..
Mosquito   935 ETIKFAKGLVTNFTTHSIPIPPNLRSVAYIGSVLSGEFQYW-------QFCWDRYMTVRREKSSV 992

  Fly   791 -SEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQY---IAANPVGEPVVWEFYRE 851
             .|:::|:..| ||....:|.:.|.      |.|.:...|..||.   ||..|.|..:...|.:.
Mosquito   993 LEERMELLRAL-GVTKDAWLQNRLL------SHVITLPVFEIVQVLEAIAGTPTGGAMACRFLQA 1050

  Fly   852 QWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIE 916
            :|....::.|.....|.|:|:.||...::....:|::....::.: |.|.......:.|:..|:|
Mosquito  1051 KWFDFQSKLGRGTVQFARVISAITQYGSTKFDYDELKSLVERFGD-GPGLKLLNMTLSTVAANVE 1114

  Fly   917 WLSRNEADITDWL 929
            |:||::|.|..|:
Mosquito  1115 WVSRSQASIYSWI 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	132/566 (23%)
		ERAP1_C	592..912	CDD:463368	89/339 (26%)
LOC1270378	XP_309093.5	None