DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and Rnpepl1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_852070.3	Gene:	Rnpepl1 / 108657	MGIID:	1914170	Length:	720	Species:	Mus musculus

Alignment Length:	463	Identity:	114/463 - (24%)
Similarity:	186/463 - (40%)	Gaps:	104/463 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 RQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSVSMSTYLVCIIVS 259
            |..|||||.||:|.|::..|..|.|   ....|..|:|.|:.:.....|.....:..|||.::..
Mouse   198 RSFFPCFDTPAVKCTYSAVVKAPLG---VQVLMSATQSVYVEEEGLYHFHMEHPVPAYLVALVAG 259

  Fly   260 DFASQSTTVKANGIGEDFSMQA------YATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKL 318
            |       :|...||....:.|      .|||.....||   ::..|....|     .||...:.
Mouse   260 D-------LKPADIGPRSRVWAEPCLLPTATSKLSGAVE---QWLSAAERLY-----GPYMWGRY 309

  Fly   319 DMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWN 382
            |:..: |.|...|||: ..:|:..:::|....:        :...:.||:||.||||.||...|.
Mouse   310 DIVFLPPSFPIVAMEN-PCLTFIISSILESDEF--------LVIDVIHEVAHSWFGNAVTNATWE 365

  Fly   383 DLWLNEGFARYMQYK-----------------GVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSH 430
            ::||:||.|.|.|.:                 .::|:|....:|.:.     .||.....||  .
Mouse   366 EMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMRLLGED-----SPVSKLQVKL--E 423

  Fly   431 PIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGA-EKFEEAVTNYLVKHQFNNTVTDD---- 490
            |.|    :|..:..:|   :||||...:..|..|.|. ::|::.:..|:.|::|.:.|..|
Mouse   424 PGV----NPSHLMNLF---TYEKGYCFVYYLSQLCGGPQRFDDFLRAYVEKYKFTSVVAQDLLDS 481

  Fly   491 ---FLTEVEAVVTD----LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQ------QRFLSNPA 542
               |..|::....|    |:.::    |....| |.|....::.|| .:|:      |.:.:.|.
Mouse   482 FLSFFPELKEQSVDCRAGLEFER----WLNATG-PPLAEPDLSQGS-SLTRPVEALFQLWTAEPL 540

  Fly   543 SYEEAPSDSAYGYKW-SVPITWFAD---DGS--------ENSFIYDYDVDSVGIAVPSEVQWIKL 595
            ....|.:.:....|| :.....|.|   |||        ..|..|...:||:...:  .::|:::
Mouse   541 EQAAASASAIDISKWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEI--RIRWLQI 603

  Fly   596 NVNQTGYY 603
             |.:..||
Mouse   604 -VVRNDYY 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	74/282 (26%)
		M1_APN_2	75..518	CDD:189008	91/358 (25%)
		ERAP1_C	593..910	CDD:288671	3/11 (27%)
Rnpepl1	NP_852070.3	M1_LTA4H	29..507	CDD:189006	90/353 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	321..325		2/3 (67%)
		Leuk-A4-hydro_C	524..668	CDD:312599	19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810