DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and rnpepl1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001335117.1	Gene:	rnpepl1 / 100535895	ZFINID:	ZDB-GENE-030131-5522	Length:	692	Species:	Danio rerio

Alignment Length:	776	Identity:	174/776 - (22%)
Similarity:	279/776 - (35%)	Gaps:	226/776 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 HYELYWHPDLETGNFTGQQRISIKVVEATNQIIL---HSYLLDITSV--------------YVLN 123
            |:.|..|.:......||.|.:.:..|:...|.::   |..|| |.||              ..|.
Zfish    50 HFHLDLHLNFAVKRITGWQVLELTPVQPGVQSLILDTHPSLL-IHSVDCKVPGASGAPDVFLSLT 113

  Fly   124 REVEKFE--------------LEEERQFLI---ITLTEELAV---DASITLGIIFGGQMKDKLVG 168
            ..||.|.              :...|.|.:   .|.|:..|:   ||.:|
Zfish   114 YRVEPFTDYGSSLNITLPAAVIRPHRAFRVTVRYTTTDGPAIWWLDAELT--------------- 163

  Fly   169 LYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESN 233
                     .|.||.:..|:......|..|||||.||:|:|::.||..|.|   ....|..:.|.
Zfish   164 ---------CGQTRPLVFTQGHSVCNRSFFPCFDTPAVKSTYSATVRVPEG---VTVLMSASRSA 216

  Fly   234 YLGDYTEAIFETSVS--MSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALE 296
            |  ...:.:|:.|:.  :..|||.::..|........::....|...:.. |.|.....||..|.
Zfish   217 Y--SKQDRVFQFSMEYPVPAYLVALVAGDLQHADIGPRSRVWAEPCILTC-AVSKLGGSVERWLN 278

  Fly   297 FGQAVTEYYIQYYKVPYPLTKLDMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIA 360
            ..:.:..        ||...:.|:..: |.|...|||: ..:|:..:::|        .:::.:.
Zfish   279 VAEGLFG--------PYVWGRYDLVFLPPSFPIVAMEN-PCLTFIISSIL--------ESQEFLL 326

  Fly   361 GTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPD-WGMLEQ-FQIVAL--QPVL 421
            ..:.|||||.||||.||...|.::||:||.|.|.|.:.....:.: :..||. |::.||  |..|
Zfish   327 IDVIHEIAHGWFGNAVTNATWEEMWLSEGLATYAQRRITTEAYGEAFTCLETVFRLDALHRQMRL 391

  Fly   422 LYDAKLSSHPIVQ---KVESPDEITAIFDTISYEKGGSVIRMLETLVG-AEKFEEAVTNYLVKHQ 482
            |.|    ::|:.:   |.|.....:::.:..:||||...:..|..|.| .::|:..:..|:.|.:
Zfish   392 LGD----NNPVSKLQAKFEPGVNPSSLMNLFTYEKGFCFVSYLSQLCGDIKRFDSFLRAYIEKFR 452

  Fly   483 FNNTVTDD-------FLTEV-EAVVTD---LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQR 536
            |::.:..|       |..|: |..|..   |:.::    |....|.|
Zfish   453 FSSVIAQDLLDFFLGFFPELKEGCVAQREGLEFER----WLNGCGPP------------------ 495

  Fly   537 FLSNPASYEEAPSDSAYGYKWSVPITWFAD----DGSENSFIYDYDVDSVGIAVPSEVQWIKLNV 597
             |..|        |.:.|...:.|:....|    |..:...|..:|:.|          |   :.
Zfish   496 -LCEP--------DLSAGRTLTGPVQHLCDLWGNDAPDTQVISTFDLSS----------W---ST 538

  Fly   598 NQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAF-ALADANQLSYKIPLDMTAYLAQ 661
            .||..:           |.:.|..||...|:..   ||:..: ||.|          ||.|.:.
Zfish   539 FQTVLF-----------LDRLLDRSPLSQEVMS---LLSSCYAALLD----------DMNAEVQ- 578

  Fly   662 ERDFVPW---------YVASNKLRSL---HRSLMFSEGYVSYLTYARSLIAGVYE----EVGWTV 710
                :.|         |....::||.   |.|.|::      :.....|..||.:    ||.:..
Zfish   579 ----IRWLQIVVRNSFYPDLPRVRSFLHKHTSRMYT------VPLYEDLCGGVMKCFAVEVFYQT 633

  Fly   711 DADNH--LKNRLRVSILTAACALG---VPDCLQQASERFSTFLENPTTRPSPD----LREI 762
            .|..|  |:..|: .||....||.   .|..:..|....|:     .|.|.|:    ||::
Zfish   634 QARLHPNLRRTLQ-QILFQTSALNTSTAPSLMASAPSAPSS-----PTDPPPNGTIALRDV 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	102/424 (24%)
		M1_APN_2	75..518	CDD:189008	119/500 (24%)
		ERAP1_C	593..910	CDD:288671	43/196 (22%)
rnpepl1	NP_001335117.1	M1_LTA4H	36..490	CDD:189006	118/495 (24%)
rnpepl1	NP_001335117.1	Leuk-A4-hydro_C	507..649	CDD:312599	38/190 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810