DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and erap1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_002933475.2	Gene:	erap1 / 100496768	XenbaseID:	XB-GENE-983344	Length:	932	Species:	Xenopus tropicalis

Alignment Length:	907	Identity:	310/907 - (34%)
Similarity:	478/907 - (52%)	Gaps:	66/907 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFEL 131
            ||||...|.||:|..||:|.|..|:|..::::.|.:.|:.::|||..|:||.. .:.|::.|..:
Frog    52 RLPTFAAPLHYDLLIHPNLTTLTFSGLTKVTVTVTQKTSFLVLHSKHLEITKT-TIKRKLGKDPV 115

  Fly   132 EEERQFLIITLTEELAVDA--------SITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTK 188
            .::.......:.|::|:.|        :.|:.|.:...:.....|.|.|||..:.|..|.:::|:
Frog   116 LQDLLLREHPVNEQIALLAADPLIPGENYTIYIEYNANLSKNFRGFYKSTYKTKDGEVRVLASTQ 180

  Fly   189 FEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTES-NYLGDYTEAIFETSVSMSTY 252
            ||||.||.|||||||||.||:|:|. :.....:||||||...:: |..|...|..|..||.||||
Frog   181 FEPTAARTAFPCFDEPAFKASFSIQ-IRREPKHHAVSNMPVVKTVNIGGGLLEDHFAASVKMSTY 244

  Fly   253 LVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTK 317
            ||..|||||.|.| .|..:|:    .:..|||..:|::.|:||:....:.::|..|:.:.|||.|
Frog   245 LVAFIVSDFKSIS-QVTNHGV----RISVYATPEKIDQAEYALKAAVKLLDFYEDYFNISYPLPK 304

  Fly   318 LDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWN 382
            .|:||||||.|||||:|||.||||:|||:||..|:.::|..:...:|||:|||||||||||:|||
Frog   305 QDLAAIPDFQSGAMENWGLTTYRESALLHDPKTSTASHKLWVTMIIAHELAHQWFGNLVTMEWWN 369

  Fly   383 DLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFD 447
            |||||||||::|:|..|...:|:. .:|.:.:......:..|:..|||.:...||:|:||..:||
Frog   370 DLWLNEGFAKFMEYVSVRVTYPEL-QVEDYFLDKCFRAMDVDSLNSSHAVSTPVENPEEIQEMFD 433

  Fly   448 TISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDF---LTEV-------------- 495
            .:||:||..::.||...:|||.||..:.:||.::.:.|...:|.   :|:|
Frog   434 EVSYDKGACILNMLMDYMGAESFEAGIVDYLRRYSYRNARNEDLWNSMTDVCPSDETNSGYCTKT 498

  Fly   496 -------EAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSF-KVTQQRFLSNPASYEEAPSDSA 552
                   |..:  :|:|.:|.|||.|.|:|::.|:  ..|.: .:.|:.:|......|      |
Frog   499 RQTSHWSEGEI--IDVKSMMNTWTLQKGFPLVTVT--VKGKYVYLHQEHYLKGSTDTE------A 553

  Fly   553 YGYKWSVPITWF-ADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLI 616
            .|..|.:|:|:. :...:...|:.....|.:.:|  .||:|||.||...|||.|:||...|..||
Frog   554 SGLLWHIPLTYITSKSNTVQRFLLMSKTDVLVLA--EEVEWIKFNVGMNGYYIVHYEGEGWDALI 616

  Fly   617 QQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRS 681
            :.|..:.......||.:|:|.||.|....:|.....|.::.||..|...:|.:...::|..:::
Frog   617 KLLQENHTAISSNDRANLINSAFQLVSIGRLPIDKALSLSLYLKNEDKIMPVFQGMDELIPIYK- 680

  Fly   682 LM----FSEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASE 742
            ||    ..|.......|..:|:..:.:...|| |..:..:..||.|:|..||......|:|:|.:
Frog   681 LMEKRDMQEVESQMKKYILNLLRKLIDAQSWT-DEGSVSERMLRSSLLLFACVRQYQPCVQRAEQ 744

  Fly   743 RFSTFLENPTTRPSP-DLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNS 806
            .|..:.|:..|...| |:...||..|.|   :...||.||:.:......|||.::...|: :.:.
Frog   745 YFKRWQESNGTISLPRDVASAVYAVGAQ---TPEGWDFLFEKYKTTLSGSEKNQIELALA-ITSL 805

  Fly   807 QYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLI 871
            ::...:|.:.......||:||....|.|::.||||.|:.|||.:..|..|..:|.|.:|..|.::
Frog   806 KHKLQWLMEEGMKGDHVRTQDLPHIVLYVSRNPVGYPLSWEFLKNNWGNLVQKFELGSRTVGDMV 870

  Fly   872 AQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWLSGTA 933
            ..||..:::...||||..||....|.|:......:|.|||:.||.|:.:|...:..||...:
Frog   871 VGITKQYSTKEWLEEVTGFFDSLKEMGSQLRCVQQARETIEENIRWMDKNLDLVKSWLENNS 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	166/395 (42%)
		M1_APN_2	75..518	CDD:189008	185/475 (39%)
		ERAP1_C	593..910	CDD:288671	94/321 (29%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	182/470 (39%)
erap1	XP_002933475.2	ERAP1_C	592..911	CDD:378732	97/324 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5500
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020