DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and enpep

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	898	Identity:	344/898 - (38%)
Similarity:	526/898 - (58%)	Gaps:	47/898 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KREDTT----DYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSV 119
            ||:|:.    ::||||.:.|.||.:..||.:|...:.|...|.:::.:.:..:.||.....|...
Frog    87 KRDDSNGDWKEFRLPTYINPVHYNVELHPVMEQDTYNGTVSIWLRLSKTSKHLWLHLRETKIIGQ 151

  Fly   120 YVLNREVEKFELEE-----ERQFLIITLTEEL----AVDASIT--LGIIFGGQMKDKLVGLYSST 173
            ..|.|..::..:::     ..::|::...:.|    ..|.:.|  |.:.|.|::...|||.|.:|
Frog   152 LTLTRGSQQIPIQQCFQYIPNEYLVLEAQQVLDPNSPTDENDTYCLTLQFAGRLDGSLVGFYRTT 216

  Fly   174 YLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD- 237
            | .|.|.|::|:....|||.||::|||||||..|||:.|:::|.. .|.|:|||...||..||:
Frog   217 Y-QENGVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHRE-EYDAISNMPVQESVALGNG 279

  Fly   238 YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVT 302
            :...:||.||.|||||||..|..|.......| .|:    .::.|....|....|:|....:.|.
Frog   280 WKRTLFEKSVPMSTYLVCFAVHQFKYVERLSK-RGV----PLRIYVQPLQNATAEYAANTTKIVF 339

  Fly   303 EYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEI 367
            :::.:|:.:||.|.|||..|||||.:||||:|||:|||||.|||||:.|:|.|||.:|..:|||:
Frog   340 DFFEEYFNMPYSLPKLDQIAIPDFGTGAMENWGLITYRETNLLYDPNESATVNKQRVAAVIAHEL 404

  Fly   368 AHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPI 432
            .||||||:|||.||:|||||||||.:.:|.||:|..|.|.||:|..|..|.||:..||.||||||
Frog   405 VHQWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQILIDDLLPVMRDDALLSSHPI 469

  Fly   433 VQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEA 497
            :..|.:|.|||::||.|||.||.|::||||..:..|.|::...:||..:.|.|..||||...: |
Frog   470 IVTVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQDYLKDYVFKNAKTDDFWNSL-A 533

  Fly   498 VVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNP-ASYEEAPSDSAYGYKWSVPI 561
            ..:...:|::|.|||.|||||||||..:.    .|.|.|||.:| |:..|.||:  :.|.|::|:
Frog   534 KASGKPVKEVMDTWTRQMGYPVLNVESLN----TVKQTRFLLDPNANALEPPSE--FNYMWNIPV 592

  Fly   562 TWFADDGS-ENSFIYDYDVDSVGIAV----PSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTT 621
            |::|.:.| :.:.:|:..:.: |:::    .:...::|:|....|::|||||.|.|..|...|..
Frog   593 TFYATNNSVDYNLLYNKSIPA-GLSLTPFNDATDGFLKINTRHLGFFRVNYELSTWNQLSALLEA 656

  Fly   622 SPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSE 686
            :...|..|||..|::||||||.|.:|.|.|.||:|.||.:|.:::.|..|.:.|..|  |.|..:
Frog   657 NHETFTDADRAGLIDDAFALARAEKLDYNISLDITKYLEKETNYLTWTRAISSLAYL--SDMLED 719

  Fly   687 G---YVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFL 748
            .   |..:..|.|..:..:.::.||. |..:.:...||.|:|..:|.:|.||.|.:||..|..::
Frog   720 DNTIYPKFQEYLRKQVKPITQKHGWE-DTGSDIDKLLRASVLALSCKMGDPDALNEASRLFRDWI 783

  Fly   749 ENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFL 813
            ...:.  ..:||::||.||||||.:|.||:.:||.::..:.|.||.||:.||:...|.: |.|..
Frog   784 GGKSI--PVNLRQLVYRYGMQQSGNQESWNYMFQQYLTTSLAQEKEKLLQGLASANNIE-LIDRY 845

  Fly   814 AQASSDESIVRSQDYFTCVQYIAA-NPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITAN 877
            .:...:.|:::|||....:.||:. :..|:.:.|::.|..|..|..|:.:|:||.||::.:|:..
Frog   846 LKLIYNTSLIKSQDALNVIYYISVYSQYGKQMAWDWVRINWDYLVDRYNINDRNLGRIVTRISGT 910

  Fly   878 FASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWLS 930
            |.::.:|.::::||.|||.:|||...|.:|:||::.||||::.|:..|..||:
Frog   911 FNTATQLWQMENFFEKYPNAGAGEIPRKQALETVRNNIEWVAANKEGIKSWLN 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	169/398 (42%)
		M1_APN_2	75..518	CDD:189008	190/454 (42%)
		ERAP1_C	593..910	CDD:288671	112/320 (35%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	186/449 (41%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	114/324 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	255	1.000	Domainoid score	I2005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	661	1.000	Inparanoid score	I761
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm47555
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970