DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and trhde

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	1006	Identity:	293/1006 - (29%)
Similarity:	498/1006 - (49%)	Gaps:	125/1006 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QVVLSWAVVAFATATV-VVAV----------------------------QKAQLERDLRD----- 39
            ::||::|:...|...| ::||                            |..:|::|..:
Frog    55 KLVLAFAISILALIVVTIIAVLLSVRFEECTDGSTRVINSSILEAARFNQNLELDKDSGEGTQRP 119

  Fly    40 -VQDKIDVFEEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEA 103
             |:|..:.::.|             |..||||:|.|.||.|.....:....|.|:..:.|:.:.:
Frog   120 PVKDPEEEWKPW-------------TYLRLPTHLRPLHYNLMVTAFMNNFTFCGEVNVEIECLNS 171

  Fly   104 TNQIILHSYLLDITSVYVLNR------EVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQM 162
            :..|::|::.|.:..|.|...      :|..:....:.|.|::.|...|....|..|.||:...:
Frog   172 SRYIVVHAHRLTVERVQVAEDRVAGEVKVSHYFPYPQNQVLVVVLNRSLEAQKSYNLKIIYSAII 236

  Fly   163 KDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNM 227
            :::|:|.:.|:|:.. |..|:::.|:|.|.:||:||||||||..||||.|::.|.: ||.::|||
Frog   237 ENELLGFFRSSYVLH-GERRSLAVTQFSPIHARKAFPCFDEPIYKATFKISIRHQT-SYLSLSNM 299

  Fly   228 Q-QTESNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINK- 290
            . :|.....|.:....|..:..||||.:...|.:|..:....::..:     ::.||....|.:
Frog   300 PVETSVFEEGGWVTDHFSQTPLMSTYYLAWAVCNFTFKEAVTQSGVV-----VRLYARPDAIRRG 359

  Fly   291 -VEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTA 354
             .::||...:.:.|:|..|::|||.|.|||:.|:|.....|||:|||..:.|..:|.|||.||.:
Frog   360 SGDYALNITKRLLEFYEDYFRVPYSLPKLDLLAVPKHPYAAMENWGLSVFVEQRILLDPSISSIS 424

  Fly   355 NKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQ-FQIVALQ 418
            ....:...:.|||.|||||:|||..||.|:||.||.|.|.::.|.:.::|.|.|.:| |....|.
Frog   425 YLLDVTMVIVHEICHQWFGDLVTPIWWEDVWLKEGLAHYFEFVGTDYLYPGWNMEKQRFLTDVLH 489

  Fly   419 PVLLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQF 483
            .|:|.|...||||:.|:|....:|..:||.|:|:||.::||||...:|.:.|:..:.:||..|::
Frog   490 EVMLLDGLASSHPVSQEVLKATDIDRVFDWIAYKKGAALIRMLANFMGHKVFQRGLQDYLTTHKY 554

  Fly   484 NNTVTDDFLTEVEAVVTD----LDIKKLMLTWTEQMGYPVLNV--SKVADGSFKVTQQRFLSNPA 542
            .|...:|....:..|:.:    |:|:::|..||.||||||:.:  :...|....:||:.||.|
Frog   555 GNAARNDLWNTLTKVLKNEGKLLNIREVMDQWTLQMGYPVITILRNDTTDDIITITQEHFLYN-- 617

  Fly   543 SYEEAPSDSAYGYK---WSVPIT---------------WFADDGSENSFIYDYDVDSVGIAVPS- 588
             .::...|..:..|   |.:|:|               |.::....:             .:||
Frog   618 -IDKRTRDKEFRNKSSLWQIPLTIAVGNTSHISPQAIIWVSNKSEYH-------------RIPSL 668

  Fly   589 -EVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIP 652
             |..|:..|::|.||:||||:...|.||..||..:.....:::|..|::|||.||.|..|:..||
Frog   669 DESNWVLGNLDQIGYFRVNYDVRNWRLLTDQLMRNSEVISVSNRAALIDDAFNLARAGYLTQNIP 733

  Fly   653 LDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADN--- 714
            |::..||::|:||:||:.||..|..|.:.|..:|.|..:..|....::.:|..:||..:..|
Frog   734 LEIIRYLSEEKDFLPWHAASRALYPLDKLLDRTEDYSIFSEYILKQVSTMYFRLGWPTNGQNGSA 798

  Fly   715 ----HLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQS 775
                :....||..::..||:.|...|.|:|:...|.::.:...|..|::|:|||..|: ....:.
Frog   799 VPTSYQTEELRREVIMLACSFGNKQCHQKAATMISDWISSNRNRIPPNVRDIVYCTGV-SLMDED 862

  Fly   776 SWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPV 840
            .|:.::..|.:.|..|||..|:..|: ..:::.|.:.|...|.:..:|..||....:.::|.||.
Frog   863 VWEFIWMKFHSSTAVSEKKILLEALT-CSDNRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPH 926

  Fly   841 GEPVVWEFYREQWPQLTTRFG----LNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGA 901
            |..:.|:|:|::|..|..|:|    :|:    :||:.:|....:..:|.|::.|..:: :.|:..
Frog   927 GRDLAWKFFRDKWKILNARYGEALFMNS----KLISGVTEFLNTEEELNELKDFIQQH-KGGSAV 986

  Fly   902 NSRLEAVETIKYNIEWLSRNEADITDWLSGT 932
            .|...|.||:..|:.|......::..||..|
Frog   987 ASLSRATETVDANVRWQHLYRDELFQWLRKT 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	136/396 (34%)
		M1_APN_2	75..518	CDD:189008	152/456 (33%)
		ERAP1_C	593..910	CDD:288671	95/327 (29%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	148/451 (33%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	98/331 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020