DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	966	Identity:	328/966 - (33%)
Similarity:	503/966 - (52%)	Gaps:	94/966 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTDYRLPTNLVPTH 76
            |....:..|:...:|.:...||   |...:..:   |.|.             :||||..|.|.:
Zfish    11 LGCTFLGMASLATIVGLWTVQL---LPTTESHV---EPWK-------------EYRLPDTLFPHY 56

  Fly    77 YELYWHPDLETGN-----FTGQQRISIKVVEATNQIILHSYLLDITSV--YVLN---------RE 125
            |.:...|.|:..:     |||...:..|.:..|:.||:|...|::||.  |:..         ..
Zfish    57 YNITLWPRLQPDDHGLYVFTGNSSVVFKCLRETDIIIIHCNKLNLTSEDGYLAKLSAFSTSEVPS 121

  Fly   126 VEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFE 190
            |:|..:||..|:|::.|..:|.......|...|.|::.|.|.|||.|.| :|.|..:.::|::..
Zfish   122 VKKTWIEEMTQYLVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEY-DEDGEKKIVATSQMH 185

  Fly   191 PTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTES-NYLGD---YTEAIFETSVSMST 251
            ||:||:.|||||||||||.|.||::|..|:. |:||..:.|: :.:.|   .|...||.:..||:
Zfish   186 PTHARKTFPCFDEPAMKAVFHITLIHDRGTV-ALSNGMEIENVDTIVDGQPVTVTTFEPTKIMSS 249

  Fly   252 YLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQI--NKVEFALEFGQAVTEYYIQYYKVPYP 314
            ||:.::|||:   :....|:|.    .::.:|....|  ...::||.....:.:::..||.||||
Zfish   250 YLLALVVSDY---TNVTSADGT----LIRIWARKKAIEDGHGDYALNITGPILKFFENYYNVPYP 307

  Fly   315 LTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMK 379
            |:|.|..|:|||..||||:||||.|||:.|||||:.||.|||:..|..:|||:||.|||||||:|
Zfish   308 LSKSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELAHMWFGNLVTLK 372

  Fly   380 WWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVE---SPDE 441
            |||::|||||||.|:.|.|.:...|.|.:.:...:..:..|...||..||||:..|.|   .|::
Zfish   373 WWNEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLSSKEEDIIKPEQ 437

  Fly   442 ITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVT------ 500
            |...|||:||.||.||:|||...:....|.:.:..||......|||.:|....::..|.
Zfish   438 IIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDLWDHLQTAVNKTGTVL 502

  Fly   501 DLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFA 565
            .|.:|.:|..|..|||:||:.|:....   :|:|..||.:|.|  .....|.:.|:|.|||.|..
Zfish   503 PLSVKVIMDRWVLQMGFPVVTVNTTTG---QVSQMHFLLDPES--SLQRTSPFNYEWIVPINWMK 562

  Fly   566 DDGSENSF-------IYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSP 623
            ....::.|       :|: |:.:.|      .:|:.||:|.||||||||:...|..|:.||..:.
Zfish   563 SKMVQSRFWLLERTAVYN-DMKTTG------SEWVLLNLNITGYYRVNYDIGNWERLLNQLAENH 620

  Fly   624 ARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGY 688
            ....:.:|..:::|||.||.|..:...:.|..|.||::||:::||..|.|.|...:  |||::..
Zfish   621 KVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQSALNNLDYFY--LMFTQTE 683

  Fly   689 VSYL--TYARSLIAGVYE-----EVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFST 746
            |..|  :|.:..:..:::     ...|:.....|.....:|:.:..||:.||.:|....|..:..
Zfish   684 VYRLLQSYTKKQVTPLFDYFKTITEDWSDVPSGHTDQYNQVNAIRFACSTGVDECQNLTSSWYKQ 748

  Fly   747 FLENPTTRP-SPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLF 810
            :::.|...| .|:||..||...:....:: .||..:.:|  :..|.|..|||..|:..:|...|.
Zfish   749 WMDQPNHNPIHPNLRSTVYCSAIATGGAE-EWDFGWTMF--KNAAIEADKLMSSLACAKNQTLLK 810

  Fly   811 DFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQIT 875
            .:|.. :.|.|::|.||..:.:.|||:||.|:.:.|||.|.:|..:.|.:|:.:.||..||:.||
Zfish   811 RYLGY-TLDPSMIRKQDATSVIVYIASNPDGQKLAWEFVRNKWEYMFTEYGVGSFNFASLISGIT 874

  Fly   876 ANFASSVKLEEVQHFFSKYPESGAG-ANSRLE-AVETIKYNIEWLSRNEADITDWL 929
            ..|::..:||::..|.|...|.|.| |.:.|| |:|..|.||:|::.|:.||||||
Zfish   875 KTFSTEAELEQLLKFKSDNSEIGFGSATAALEQAIEKTKANIKWVAENQEDITDWL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	161/411 (39%)
		M1_APN_2	75..518	CDD:189008	178/473 (38%)
		ERAP1_C	593..910	CDD:288671	103/326 (32%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	161/411 (39%)
		M1_APN_2	57..520	CDD:189008	178/471 (38%)
		ERAP1_C	590..911	CDD:288671	103/326 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920