Protein Alignment CG8773 and NPEPPS

DIOPT Version :10

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_001398059.1
• Gene: NPEPPS / 9520
• HGNCID: 7900
• Length: 924
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 292/899 - (32%)
• Similarity: 464/899 - (51%)
• Gaps: 73/899 - (8%)

  Fly   111 GTTASPEKIDY-RLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSV 174
            |..|.|||..: |||..:.|.:|.|.|.|::....|.|:......|.:||:|||::..:::|.:.
Human    41 GLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITA 105

  Fly   175 SIMNTGSDTLEILETTVDAVREFLIFQLNEPLT-KGRTVRLHIGFEGSMANKIVGLYSSSYVKED 238
            |....|.:  ||..|..:...|.....|:.|.| :..|..|.|.|.|.:.:|:.|.|.|.|....
Human   106 SYAPEGDE--EIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPS 168

  Fly   239 ETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--------DSSVS 295
            ...::.|.::||.|.||:||||:||||:||.|.|:||.|  :|..|||||||        |.::
Human   169 GEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVP--KDRVALSNMNVIDRKPYPDDENL- 230

  Fly   296 QGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGK 360
                .||.||::..|||||..|:|.::.:    ::|:. .:...:.||....:.::...|:.:..
Human   231 ----VEVKFARTPVMSTYLVAFVVGEYDF----VETRS-KDGVCVRVYTPVGKAEQGKFALEVAA 286

  Fly   361 GVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIA 425
            ..:.:|.|||.:.|||||:|:.||.||.:||||:|||||||||:||.|...|.::::|.:|.|:.
Human   287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVG 351

  Fly   426 HEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGS 490
            ||.||.||||||||.||..|||||||||::|||.||..:||:.:..||..:.......||....|
Human   352 HELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNS 416

  Fly   491 HPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTE 555
            |||..:|.:|.::.||||.|:||||:|::|||.|::|:..|::.:..||.:::...|.|.:.:..
Human   417 HPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWES 481

  Fly   556 IDKLELGYNVTEIMLTWTVQMGLPVVTI--EKVSDTE-YKLTQKRFLSNPNDYDADHEPSEFNYR 617
            ::... |..:..:|.|||.|||.|::.:  |:|.|.. .:|:||:|.:. ..|..:..|     :
Human   482 LENAS-GKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAG-GSYVGEDCP-----Q 539

  Fly   618 WSIPITYFTSSDSVVQRLWFYHDQSEITVTVPAAV--EWIKFNADQVGYYRVNYDTDLWNDLADQ 680
            |.:|||..||.|....:|....|:.|:.|.:....  :|:|.|...||:||..|.:.:...|...
Human   540 WMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPG 604

  Fly   681 LVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLY 745
              ::..:...|||..|.||.|:||.:..:......::......|.:|..||..:..|..|...|.
Human   605 --IRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLS 667

  Fly   746 YTSTYAKYKKYATALIEPIYTALTW--TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAW 808
            :|..|.:.:::...:..||...|.|  ..||.|||..||...|......|.::.|.||..:|...
Human   668 HTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDH 732

  Fly   809 LAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRY 873
            : :.:....||:|..||...::. |.....|.:.:|........||:::...|.|..:|.::|:.
Human   733 V-EGKQILSADLRSPVYLTVLKH-GDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKV 795

  Fly   874 IDLAWNEEYVRGQDYFTCLTYIS-ANPVGESLVWDYVRENWQRLVDRFG--------LNERYLGN 929
            :..|.:|| ||.||..:.:..:: .:..|....|.::::||:.|.:|:.        :..::|..
Human   796 LTFALSEE-VRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKVQWLTP 859

  Fly   930 LIPSITARFSTQTKLEEMEQFFAKYPEAGAG-----TAARVRALETVKNNIVWL 978
            :||::            .:....:.||.|:.     |..::|.|:.:|    ||
Human   860 VIPAL------------WDAEVGRSPEVGSSRLSWPTCYQLRDLQLIK----WL 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	KLF9_13_N-like	<17..118	CDD:425361	3/6 (50%)
		M1_APN-Q_like	130..573	CDD:341064	174/451 (39%)
		ERAP1_C	654..973	CDD:463368	80/334 (24%)
NPEPPS	NP_001398059.1	M1_APN-Q_like	61..499	CDD:341064	175/452 (39%)
		ERAP1_C	578..854	CDD:463368	71/280 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	726..730		0/3 (0%)