Protein Alignment CG8773 and AAP1

DIOPT Version :10

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 887
• Identity: 278/887 - (31%)
• Similarity: 438/887 - (49%)
• Gaps: 63/887 - (7%)

  Fly   123 LPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLN------LNISSVSIMNTGS 181
            ||..:.|.|||:.|.||.....|.|...|.:.:.:       ||:|      |.|...|....|.
Yeast     6 LPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQIND-------HSINSVQINYLEIDFHSARIEGV 63

  Fly   182 DTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKE--DETRKWI 244
            :.:|: ....:..:..|:|........|.:.:|.|.|.|.:.:::.|.|.:.|..:  .|| |::
Yeast    64 NAIEV-NKNENQQKATLVFPNGTFENLGPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGET-KYM 126

  Fly   245 ATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQEVTFAKSVP 309
            ||::.|.|.||:||||||||.|||.|.:|||..|...:  ||||:|.:...:...:..||..:..
Yeast   127 ATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTH--LSNMDVRNETIKEGKKYTTFNTTPK 189

  Fly   310 MSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAY 374
            |||||..|||:|..|    :::...  ...:.||:||........|..:....:.::.|.|.|.|
Yeast   190 MSTYLVAFIVADLRY----VESNNF--RIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIEY 248

  Fly   375 PLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTM 439
            ||||:||.|:.:|.:||||:|||||||...||.|...||....||:|.||.||.||.||||||||
Yeast   249 PLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTM 313

  Fly   440 NWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQIT 504
            :||..||||||||:::.:...:...||||:.:|:....|...|.||....||||...|.|.|:|.
Yeast   314 DWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEIN 378

  Fly   505 EIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKLELGYNVTEIM 569
            :|||.|:|||||||:||:..:|||.||.:.|:.|||::||..|:||:.:..:.... |.:|..:|
Yeast   379 QIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADAS-GKDVCSVM 442

  Fly   570 LTWTVQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVV-- 632
            ..||.::|.||::: |....:..|||.|:||..   |...|.....|...:.:...|..|:.:
Yeast   443 NIWTKRVGFPVLSV-KEHKNKITLTQHRYLSTG---DVKEEEDTTIYPILLALKDSTGIDNTLVL 503

  Fly   633 -QRLWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQ---LVVQPSAFGSVDR 693
             ::...:..::|         |:.|.|.||.|.:..:|..:.|..|:.|   |.|:       ||
Yeast   504 NEKSATFELKNE---------EFFKINGDQSGIFITSYSDERWAKLSKQANLLSVE-------DR 552

  Fly   694 AHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYY--TSTYAKYKKY 756
            ..|:.||.||:.|..........|......|..:|.|....:.|::||.|..:  ........|:
Yeast   553 VGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKF 617

  Fly   757 ATALIEPIYTALTWTVGEDHLDN----RLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPK 817
            ...|:....:.|.|.:|||  |:    ||:||..||||:.|.|...:.|.|.|..: |....:..
Yeast   618 TLDLVLNKLSELGWNIGED--DSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEY-ANGNKQAI 679

  Fly   818 ADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEY 882
            ..:.:.|.:..:..:|.:.:::.::.::.|...:.||...:..|...:...:|:|.:.... :..
Yeast   680 PALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLL-DGT 743

  Fly   883 VRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEM 947
            |..||::..:..|..:..|...:|.:::|:|..:..|.......||.::......|::...||::
Yeast   744 VLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKI 808

  Fly   948 EQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAWL 989
            ..|:::....|..... .:||:|:::...|::.:.|.|..:|
Yeast   809 SAFYSRKVTKGFDQTL-AQALDTIRSKAQWVSRDREIVATYL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	KLF9_13_N-like	<17..118	CDD:425361
		M1_APN-Q_like	130..573	CDD:341064	176/450 (39%)
		ERAP1_C	654..973	CDD:463368	76/327 (23%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	177/451 (39%)
		ERAP1_C	517..833	CDD:463368	76/327 (23%)