DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and TMA108

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	216/986 - (21%)
Similarity:	402/986 - (40%)	Gaps:	193/986 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 LPGTLKPTHYDLYL-------FPNIETG-----EFSGQETITITVEEATDQIVLHSLNLNISS-- 173
            |...:.|:||:|.|       .||.:..     :|:...|...::|::..|..|||.:|.:.|
Yeast     8 LENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAH 72

  Fly   174 VSIMNTGSDTLEILETTVDAVREFLIFQLNEPLT---------------KGRTVRLHIGFEGSMA 223
            .:|.:|..|    |:.:.|..:...||....|:.               |.|.::.|       .
Yeast    73 ATIGSTKFD----LKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTH-------H 126

  Fly   224 NKIVGLYSSSYV--KEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALS 286
            :|..|::.::::  |.......:..:..:|..|...|||.|||:.|:.|.:.:.  :...|.|:|
Yeast   127 DKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIA--TDAQYKAVS 189

  Fly   287 NMNVDSSVSQGAFQE--VTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQL 349
            |..|:...:..:.|:  |.|||:..|:|.:..|.:.|..:.:..|..:| ..|..:|:||   ..
Yeast   190 NTPVEMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEG-DRTIPVSIYA---PW 250

  Fly   350 DKVDLAVTIGKGVIEYYI----DYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLY-DE 409
            |..:.|.|:  ..::.|:    .||:..|||||||...:|.....|||::|::|.:...||. ..
Yeast   251 DIANAAFTL--DTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPPN 313

  Fly   410 ATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFV--EYLGVDAVYPEWKMRDQ 472
            |.::.|.:::...:|.||..|.|.||.::.:.|..||.||.||:::  ..|..:.....:...:.
Yeast   314 ALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEP 378

  Fly   473 FTVSTLHSVLTLDGT-LGSHPIIQTVEN----PDQITEIFDTITYSKGSSLVRMLEDFLGETTFR 532
            :.:..:...:..|.. :....|.|..:.    ..|.::|||...|:||..::|.|:...||:..:
Yeast   379 YLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQ 443

  Fly   533 QAVTNYLNEYKYSTAET---GNFFTEIDKLELGYNVTEIMLTWTVQMGLPVVTI---EKVSDTEY 591
            :.:.:...:.|...|.:   .:.:..|.|.....|:|..:.:||...|||||.:   ||...|:.
Yeast   444 KGLESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSSWTRTPGLPVVKVEVEEKDGKTQT 508

  Fly   592 KLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEITVT-------VP 649
            ||||.||:   |....:.:....:..:.:|: :....|..:       |...:.:|       .|
Yeast   509 KLTQHRFI---NQLSTEEKDQLEDVPYQVPL-FGVLPDGKM-------DTKNVLLTDRTLKFDYP 562

  Fly   650 AAVEWIKFNADQVGYYRVNYDTD----LWND------LAD----QLVVQPSAF----GSVDRAHL 696
            ..|    .|....|||||:|:::    |.||      |::    ::.:..|.|    |..:..||
Yeast   563 ILV----INHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHL 623

  Fly   697 ------LNDAFALADSTQL------PYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTST 749
                  ||  ...:.||::      |.:...|:.:.:|:.      |:.:|:|.|..:
Yeast   624 HGLFKILN--HIASPSTKIASKYWDPLSKGLEVLQTIDRA------SLTSSKLQSFLK------- 673

  Fly   750 YAKYKKYATALIEPIYTALTWTVGE-DHLDNRLRVTALSAACSLGLES--CLTEAGEQFNAWLAK 811
                ||    ::.|::..:.|..|| |...|...:..:|....|...|  |.......|...|..
Yeast   674 ----KK----IVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQG 730

  Fly   812 PEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKL--MYGLSAIQIPWILQ--- 871
            |......::..::.....|...:.:.|..:::|....|.....:.:  ||..::.:...::|
Yeast   731 PRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGA 795

  Fly   872 -RYIDLAWNEEYVRGQDYFTCLTYISANPVGESLV-----WDY-------VRENWQRLVDRFGLN 923
             ..:....:.:.|:     ..|.:|::|...|.:.     ::|       ..|..|..|.|..:.
Yeast   796 IESLGFCLDSDIVK-----KTLNFITSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIW 855

  Fly   924 ERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARV-RALETVKNNI--VWLAENLEGV 985
            |.|:||                 .:|:..|....|..|...: :||.::...|  :::|:..:.:
Yeast   856 EWYMGN-----------------FDQWARKATRKGTTTGDHLHKALRSISLIIFQMFVADEPQKI 903

  Fly   986 DAW--LDKQPL 994
            :.:  |:|:.|
Yeast   904 EKFINLEKEKL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	107/436 (25%)
		M1_APN_2	130..579	CDD:189008	120/496 (24%)
		ERAP1_C	655..969	CDD:288671	68/365 (19%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	216/986 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910