Protein Alignment CG8773 and AOPEP

DIOPT Version :9

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 144/788 - (18%)
• Similarity: 258/788 - (32%)
• Gaps: 261/788 - (33%)

  Fly   127 LKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNIS------------------- 172
            ||....|:...|.:|  :|:....:|:..||..:|||...:.|..:
Human   154 LKVEEVDVAAVPGLE--KFTRSPELTVVSEEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCG 216

  Fly   173 ---------SVSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVG 228
                     |:.|..||:      :|..|......|:...:|  :||:|
Human   217 ELLFDTDTWSLQIRKTGA------QTATDFPHAIRIWYKTKP--EGRSV---------------- 257

  Fly   229 LYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTIT-------LVHPSGED----- 281
                ::..:...|..:.|.. .|...|..|||.:.|...:.:..|       :|..|||:
Human   258 ----TWTSDQSGRPCVYTVG-SPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPT 317

  Fly   282 ----------YHALSNMNVDS-SVSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIG 335
                      |:....|...: :::.|.:.|      :.|.|:.:..:.::..:.....:.:.:|
Human   318 QLWEECSSWYYYVTMPMPASTFTIAVGCWTE------MKMETWSSNDLATERPFSPSEANFRHVG 376

  Fly   336 ETFSM-------SVYATPEQL--DKVDLAVTIGKGVIEYYIDYFQI----------AYPLPKLDM 381
            ....|       :..||.:::  .:|...|.:.....|..:.....          |:|..:||:
Human   377 VCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDV 441

  Fly   382 AAIP-DFVSGAM--EHWGLVTYRETSLLYDEATSSATNKQRIASV-IAHEFAHMWFGNLVTMNWW 442
            ..:| :|.|..|  .|   :.:...|:|        |....:... :.||.||.|||..:....|
Human   442 LIVPANFPSLGMASPH---IMFLSQSIL--------TGGNHLCGTRLCHEIAHAWFGLAIGARDW 495

  Fly   443 NDLWLNEGFASFVE---YLGVDAVYP-------------EW-KMRDQFTVSTLH-SVLTLDGTLG 489
            .:.||:||||:.:|   :.....:.|             .| :::|:...|... .||.......
Human   496 TEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKT 560

  Fly   490 SH------PIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAE 548
            .|      .:|:...||:   :||..:.|.||..|:|.|...||:.|:...:..:::.:......
Human   561 GHTSDSGASVIKHGLNPE---KIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLIL 622

  Fly   549 TGNF-------FTEIDKLELGYNVTEIMLTWTVQMGLP--------------------------- 579
            :.:|       ..|..:|||  :|..|...|....|:|
Human   623 SQDFLQMLLENIPEEKRLEL--SVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWI 685

  Fly   580 --------------------------VVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRW 618
                                      |:.:|.:.: :..|:.:...|....|....:.:|..:||
Human   686 GVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLE-QKTLSPRTLQSLQRTYHLQDQDAEVRHRW 749

  Fly   619 SIPIT--YFTSS-----------------DSVVQRLWFYHDQSEITVTVPAAVEW-IKFNADQVG 663
            ...|.  .||.:                 ||.::.|..:..:.|:|:.:...:.| :|.:|....
Human   750 CELIVKHKFTKAYKSVERFLQEDQERPQQDSFIRLLLAWGTRLELTLDIKGGIMWLLKPSAHSPV 814

  Fly   664 YYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYV 728
            :..|......|:        ||   |:..|..|:| |.:|.....||:.
Human   815 HILVLLFPRGWS--------QP---GTHKRQILVN-AASLPGGCLLPWI---------------- 851

  Fly   729 PWSVAASR 736
             ||.||.|
Human   852 -WSGAALR 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	90/485 (19%)
		M1_APN_2	130..579	CDD:189008	105/553 (19%)
		ERAP1_C	655..969	CDD:288671	19/82 (23%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:417498	86/452 (19%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699		0/9 (0%)
		Leuk-A4-hydro_C	721..>771	CDD:401171	9/49 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810